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Ibrutinib Intermediate CAS 330792-70-6 Chiyero >98.0% (HPLC) Chithunzi Chowonetsedwa
  • Ibrutinib Intermediate CAS 330792-70-6 Purity>98.0% (HPLC)

Ibrutinib Intermediate CAS 330792-70-6 Purity>98.0% (HPLC)

Kufotokozera Kwachidule:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

CAS: 330792-70-6

Kuyera: > 98.0% (HPLC)

Maonekedwe: Woyera-Woyera mpaka Ufa Wachikasu Wowala

Pakati pa Ibrutinib (CAS: 936563-96-1) 

Lumikizanani ndi Dr. Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Mankhwala a Ibrutinib:

Ibrutinib CAS 936563-96-1
3-Hydroxypiperidine CAS 6859-99-0
1-Boc-3-Hydroxypiperidine CAS 85275-45-2
(S) -1-Boc-3-Hydroxypiperidine CAS 143900-44-1
4-Phenoxybenzoic Acid CAS 2215-77-2
4-Phenoxyphenylboronic Acid Chithunzi cha CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine Chithunzi cha CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine Chithunzi cha CAS 151266-23-8
Ibrutinib Deacryloylpiperidine CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile CAS 330792-70-6

Chemical Properties:

Dzina la Chemical 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Mawu ofanana ndi mawu Ibrutinib Wapakatikati N-3;3-Amino-5-(4-Phenoxyphenyl)pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl)pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Nambala ya CAS 330792-70-6
Stock Status Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula Chithunzi cha C16H12N4O
Kulemera kwa Maselo 276.29
Kuchulukana 1.37±0.10 g/cm3
COA & MSDS Likupezeka
Chiyambi Shanghai, China
Mtundu Ruifu Chemical

Zofotokozera:

Kanthu Zofotokozera
Maonekedwe Ufa Woyera mpaka Wachikasu Wowala
Kuyera / Kusanthula Njira >98.0% (HPLC)
Kutaya pa Kuyanika <1.00%
Zotsalira pa Ignition <0.50%
Zonse Zonyansa <2.00%
Zitsulo Zolemera (monga Pb) <20ppm
1 H NMR Spectrum Zogwirizana ndi Kapangidwe
Test Standard Enterprise Standard
Kugwiritsa ntchito Pakati pa Ibrutinib (CAS: 936563-96-1)

Phukusi & Kusunga:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.

Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi.

Ubwino:

1

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330792-70-6 - Kugwiritsa Ntchito:

5-Amino-3- (4-Phenoxyphenyl) -1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) ndi yapakatikati ya Ibrutinib (CAS: 936563-96-1).Ibrutinib imawonetsa mphamvu yoletsa komanso yosasinthika komanso kusankha kwa Btk enzymatic ntchito.Mu mzere wa cell wa BCR wa DOHH2, Ibrutinib imaletsa autophosphorylation ya Btk, phosphorylation ya Btk's physiological substrate PLCγ, ndi phosphorylation ya kinase ya pansi, ERK ndi IC50 ya 11 nM, 29 nM ndi 13 nM motsatira.Ibrutinib imawonetsa kutsika kwakukulu kodalira mlingo komanso kutengera nthawi kwa cytotoxicity m'maselo osatha a lymphocytic leukemia (CLL).Kuphatikiza apo, Ibrutinib imayambitsa kufa kwa cell kutengera caspase pathway activation ndipo imatsutsana ndi kuthekera kwa ma cell a CLL kuti achuluke pambuyo poti TLR iwonetsa.

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