CAS 361442-04-8 Purity>99.0% (HPLC) API

Kufotokozera Kwachidule:

Mawu ofanana: BMS-477118;Onga

CAS: 361442-04-8

Kuyera: > 99.0% (HPLC)

Maonekedwe: Ufa Woyera

API, High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

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Kufotokozera:

Ruifu Chemical Supply Related Intermediates
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Chemical Properties:

Mawu ofanana ndi mawu	BMS-477118;Oliza;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamntyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Nambala ya CAS	361442-04-8
Nambala ya CAT	RF-PI1991
Stock Status	Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula	C18H25N3O2
Kulemera kwa Maselo	315.41
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera
Kununkhira	Khalidwe
chizindikiritso	A: IR B: HPLC Retention Time
Kuyera / Kusanthula Njira	>99.0% (HPLC)
Kumveka kwa Water Solution	Zowonekera, Zopanda Mtundu, Palibe Zoyimitsidwa
Sieve Analysis	100% Kudutsa 80 Mesh
Melting Point	202.0 ~ 212.0 ℃
Kutaya pa Kuyanika	<0.50%
Phulusa la Sulfate	<0.20%
Kuzungulira Kwapadera	+174.0°~+186.0°
Chidetso Chimodzi	<0.50%
Zonse Zonyansa	<1.00%
Zitsulo Zolemera	<10ppm
Arsenic (As)	<2.0ppm
Kutsogolera (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Zosungunulira Zotsalira	<100ppm
Mankhwala Otsalira	Zoipa
Microbiology
Total Plate Count	<1000cfu/g
Yisiti & Mold	<100cfu/g
E. Coli	Zoipa
S. Aureus	Zoipa
Salmonella	Zoipa
Shelf Life	Miyezi 24 Kuchokera Tsiku Lopanga Ngati Zasungidwa Moyenera
Test Standard	Enterprise Standard
Kugwiritsa ntchito	API;Type 2 shuga mellitus

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi

Ubwino:

FAQ:

Ntchito:

(BMS-477118) (CAS: 361442-04-8) ndi choletsa champhamvu, chosankha, chosinthika, champikisano komanso chogwira ntchito pakamwa dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM).BMS-477118 ili ndi kafukufuku wamtundu wa 2 shuga mellitus.BMS-477118ndi mankhwala amtundu wa 2 shuga omwe amatha kulimbikitsa kapamba kupanga insulin yambiri mukatha kudya.Idafikiridwa ndi mgwirizano wa AstraZeneca ndi Bristol-Myers Squibb Company ndipo ndi ya DPP-IV inhibitor.BMS-477118imagwira ntchito poletsa kuwonongeka kwa GLP-l.GLP-I ndi mahomoni omwe amapangidwa mwachilengedwe m'matumbo atatha kudya.Imatha kuwongolera katulutsidwe ka insulini komanso kulimbikitsa kugwiritsa ntchito shuga m'maselo am'mphepete.Mankhwala amodzi a BMS-477118 amatha kusintha kuwongolera shuga m'magazi komanso kuphatikiza mankhwala a BMS-477118 okhala ndi Metformin, Sulfonylurea ndi Thiazolidinediones amatha kupititsa patsogolo machiritso.Zimayambitsa chiopsezo chochepa cha hypoglycemia ndipo zotsatira zake zimakhala zofanana ndi za placebo, kusonyeza kulolerana bwino.Pa July 31, 2009, BMS-477118 mapiritsi (Onglyza), mankhwala atsopano a matenda a shuga a 2, omwe adafufuzidwa pamodzi ndikupanga AstraZeneca ndi Bristol-Myers Squibb adavomerezedwa ndi US FDA.Itha kutengedwa kamodzi patsiku kuchiza matenda a shuga amtundu wa 2 kuphatikiza kuwongolera Zakudya ndi masewera olimbitsa thupi.