5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Intermediate Purity>98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin] -6'(1'H)-one) (CAS: 381233-78-9) yokhala ndi khalidwe lapamwamba, lapakati la Perampanel (CAS: 380917-97-5).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Perampanel intermediates,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 5-(2-Pyridyl) -1,2-Dihydropyridin-2-imodzi |
| Mawu ofanana ndi mawu | [2,3'-Bipyridin] -6'(1'H) -imodzi;5-(Pyridin-2-yl)pyridin-2(1H) -imodzi;5-(Pyridin-2-yl) -2 (1H) -Pyridone;5-(2-Pyridyl)pyridin-2(1H)-chimodzi;5-Pyridin-2-yl-1H-Pyridin-2-imodzi;5-(Pyridin-2-yl) -1,2-Dihydropyridin-2-imodzi;Perampanel Chidetso 1 |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 381233-78-9 |
| Molecular Formula | Chithunzi cha C10H8N2O |
| Kulemera kwa Maselo | 172.18 g / mol |
| Melting Point | 71.0 ~ 75.0 ℃ |
| Kuchulukana | 1.221±0.06 g/cm3 |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | Wapakatikati wa Perampanel (CAS: 380917-97-5) |
| Shelf Life | Miyezi 24 Ngati Yasungidwa Moyenera |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Woyera mpaka Pafupifupi Woyera | Ufa Woyera |
| Kuyera / Kusanthula Njira | >98.0% (HPLC) | 99.7% |
| Madzi ndi Karl Fischer | <1.00% | 0.58% |
| Chidetso Chimodzi | <1.00% | Zimagwirizana |
| Zonse Zonyansa | <2.00% | 0.30% |
| 1H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
| Kugwiritsa ntchito | Wapakatikati wa Perampanel (CAS: 380917-97-5) | |
Phukusi:Botolo la Fluorinated, thumba la Aluminiyamu zojambulazo, 25kg / Cardboard Drum, kapena malinga ndi zomwe kasitomala amafuna.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndipo sungani m'nyumba yozizira, yowuma komanso yolowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Katundu: Ufa Woyera Mpaka Pafupifupi Woyera
Zosungunulira: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Etha, Petroleum Etha, n-Hexane, Dichloromethane
Yang'anani: Zinthu Zogwirizana: Tengani mankhwalawa ndikuwasungunula ndi diluent (madzi a gawo la m'manja: methanol (50∶50)) kuti mupange yankho lomwe lili ndi pafupifupi 0.5mg pa 1ml ngati njira yothetsera mayeso.Malinga ndi high performance liquid chromatography (Chinese Pharmacopoeia 2010 Edition II Zowonjezera Ⅴ D), gelisi ya silica (ZORBAX SB-C18 4.6×250mm,5m) idagwiritsidwa ntchito ngati chodzaza.Gawo lam'manja A linali madzi, gawo B linali methanol, ndipo kutalika kwa mawonekedwe kunali 254nm.Kuthamanga kunali 1.0ml / min ndipo kutentha kwa mzati kunali kutentha kwa chipinda.5μl ya yankho loyesa idayezedwa molondola ndikubayidwa mu chromatograph yamadzi kuti ilembe chromatogram.Malinga ndi dera normalization njira, zili mankhwala si zosakwana 98%.Ngati pali nsonga zonyansa mu chromatogram ya yankho lazoyeserera, malo omwe ali pachimake pachidebe sayenera kupitilira 1.0%, ndipo kuchuluka kwa malo osadetsedwa sikudutsa 2.0%.
Chinyezi: Tengani mankhwalawa, gwiritsani ntchito choyezera chinyezi, malinga ndi njira ya Karl Fischer (Chinese Pharmacopoeia 2010 edix II Zowonjezera Ⅷ M njira yoyamba A) kutsimikiza, chinyezi sichidzapitirira 1.0%.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
5-(2-Pyridyl) -1,2-Dihydropyridin-2-imodzi ([2,3'-Bipyridin] -6'(1'H)-imodzi) (CAS: 381233-78-9), wapakatikati wa Perampanel (CAS: 380917-97-5).Perampanel (yopatsidwa chilolezo mu 2012) ndi AED ya m'badwo wachitatu yomwe imadziwika ndi dzina laumwini la Fycompa® (Eisai, Hatfield) ku UK ndi Banzel® (Eisai, Hatfield) ku USA.Chithandizo chothandizira cha kukomoka kwapang'onopang'ono ndi kapena popanda kusekondale generalization ndi primary generalized tonic-clonic khunyu.Mu Okutobala 2012, a US FDA adavomereza perampanel kuti azitha kukomoka pang'ono kwa odwala khunyu omwe ali ndi zaka zosachepera 12.Perampanel ndiye woyamba AMPA receptor antagonist kulandira chivomerezo cha FDA ngati AED.AMPA glutamate receptors amapezeka makamaka pa postsynaptic neurons mu ubongo.Monga mdani wosankha, wosapikisana wa AMPA, parampanel imalepheretsa kutsegulidwa kwa njira ya ion ndikuchepetsa kufalikira kwa kuthekera kochitapo kanthu.
