N-Ethyl-N-Methylcarbamoyl Chloride CAS 42252-34-6 Rivastigmine Tartrate Intermediate Purity>99.0% (GC)

N-Ethyl-N-Methylcarbamoyl Chloride (Ethyl(methyl)carbamic Chloride) (CAS: 42252-34-6), wapakatikati wa Rivastigmine Tartrate (CAS: 129101-54-8).Rivastigmine tartrate ndi tartrate ya rivastigmine, mankhwala ochizira matenda a Alzheimer's.Rivastigmine ndi physostigmine yochokera, yomwe idapangidwa bwino kwa nthawi yoyamba ndi Novartis, Switzerland.Dzina la malonda ndi exelon, ndipo molekyu ili ndi benzyl carbamate dongosolo, ndi carbamate brain-selective cholinesterase inhibitor, yomwe ingalepheretse acetylcholinesterase ndi butyrylcholinesterase panthawi imodzimodziyo, ndikulimbikitsanso mitsempha ya cholinergic mwa kuchepetsa kuwonongeka kwa acetylcholine yotulutsidwa ndi cholinergic. ma neurons.Itha kusintha kusokonezeka kwachidziwitso komwe kumayendetsedwa ndi cholinergic, potero kumathandizira kuzindikira kwa odwala omwe ali ndi matenda a Alzheimer's.Mapuloteni a plasma omwe amamanga mphamvu ya rivastigmine ndi ofooka, osavuta kudutsa chotchinga chamagazi-muubongo, ndipo amakhala ndi mwayi wosankha ubongo.Sizingatheke kusankha madera omwe ali pachiwopsezo cha cerebral cortex ndi hippocampus, komanso kuletsa mwapadera magulu ang'onoang'ono a AChE muubongo, omwe amatha kuchepetsa zotumphukira za cholinergic pomwe akupanga zochiritsa.Theka la moyo wa rivastigmine tartrate m'thupi ndi lalifupi ndipo nthawi yochitapo kanthu ndi yaitali.Mosiyana ndi tacrine, mankhwalawa ali ndi mphamvu yoletsa kwambiri G1 enzyme mu hippocampus ndi cortex.Amagwiritsidwa ntchito pochiza matenda a dementia pang'ono mpaka pang'ono, omwe akuganiziridwa kuti ndi matenda a Alzheimer's kapena Alzheimer's.