TMC207 CAS 843663-66-1 Chiyero>99.5% (HPLC)
| Dzina la Chemical | Mtengo wa TMC207 |
| Mawu ofanana ndi mawu | TMC-207, R207910;Sirturo;(αS, βR) -6-Bromo-α--[2-(dimethylamino) ethyl] -2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| Nambala ya CAS | 843663-66-1 |
| Nambala ya CAT | Mtengo wa RF2336 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | Chithunzi cha C32H31BrN2O2 |
| Kulemera kwa Maselo | 555.516 |
| Melting Point | 104 ℃ |
| Kuchulukana | 1.322±0.06 g/cm3 |
| Zomverera | Hygroscopic.Imamva Kuwala, Imamva Mpweya |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera kapena Woyera |
| Kuyera / Kusanthula Njira | > 99.5% (HPLC) |
| Kutaya pa Kuyanika | <0.50% |
| Zotsalira pa Ignition | <0.20% |
| Chidetso Chilichonse Chamunthu | <0.10% |
| Isomer | <0.10% |
| Zonse Zonyansa | <0.50% |
| Zitsulo Zolemera (monga Pb) | <20ppm |
| Arsenic (As) | <2.0ppm |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe |
| Proton NMR Spectrum | Zimagwirizana ndi Kapangidwe |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API |
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(CAS: 843663-66-1), (yotchedwa TMC207 ndi R207910), yogulitsidwa pansi pa dzina lamalonda la Sirturo, ndi buku la diarylquinoline antimycobacterial mankhwala omwe amakhudza chifuwa chachikulu cha TB poletsa ntchito ya M. chifuwa chachikulu cha ATP synthase proton pump.Kuphatikizika kwa ATP kwa mycobacteria kumakhala ndi antibacterial ndi bactericidal zotsatira.Zachipatala zomwe zimagwiritsidwa ntchito pochiza chifuwa chachikulu chosagwirizana ndi mankhwala ambiri (MDR-PTB).TMC207 ilinso ndi mabakiteriya omwewo motsutsana ndi mtundu wa M. TB tcheru ndi mitundu yosamva, komanso imakhala ndi mphamvu yotseketsa bwino mabakiteriya omwe adagona.Mu Disembala 2012, US FDA idavomereza TMC207 ngati gawo la mankhwala ophatikizika a matenda a chifuwa chachikulu osamva mankhwala ambiri (MDRTB).TMC207 ndi mankhwala oyamba ovomerezeka a MDR-TB ndipo ndi kuvomerezedwa koyamba kuchokera ku gulu latsopano la mankhwala oletsa chifuwa chachikulu m'zaka 40 zapitazi.Chifukwa chakufunika kosagwirizana ndi chithandizo cha MDR-TB, a FDA adapereka chilolezo chofulumizitsa TMC207 potengera zotsatira za Gawo II, kupatsa odwala mwayi wopeza mankhwalawa pomwe maphunziro owonjezera azachipatala akuchitidwa.TMC207 ndi diarylquinoline yomwe idapezedwa kuchokera ku njira yowunikira kwambiri, yowunika maselo onse ndi Mycobacterium smegmatis yomwe imagwiritsidwa ntchito ngati choloweza pa M. TB.TMC207 ndi enantiomer imodzi ya kugunda koyambirira.TMC207 ili ndi zochita zolimbana ndi mycobacteria, ndipo imagwira ntchito polimbana ndi matenda a chifuwa chachikulu a M. TB.Njira yogwirira ntchito ya TMC207 ndi yapadera pakati pa mankhwala oletsa TB ndipo imakhudzanso kuletsa kwa mycobacterial ATP synthase;sichigwira ntchito motsutsana ndi ATP synthase yaumunthu.TMC207 imagwira ntchito mu vivo m'mitundu yambiri ya matenda a TB, yokha komanso kuphatikiza ndi othandizira ena odana ndi TB, ndipo imakhala ndi zochita zowononga mabakiteriya m'mitundu yodziwika ya TB.TMC207 imapangidwa mu masitepe asanu kuchokera ku 3-Phenylpropionic Acid ndi para-Bromoaniline.Kutsatira mapangidwe a amide, chithandizo cha POCl3 ndi DMF pansi pa mikhalidwe ya Vilsmeier-Hack chinapereka mankhwala a 2-Chloroquinoline.Kuchiza ndi sodium methoxide, kutsatiridwa ndi condensation ndi 3-(Dimethylamino) -1-(naphthalen-1-yl) propan-1-imodzi, ndi kulekana kwa ma isomers kunapereka TMC207.
