Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) ee ≥99.0%
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) ndi khalidwe lapamwamba, lapakati la Crizotinib (CAS: 877399-52-5).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Crizotinib Yapakati,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | (R) -5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine |
| Mawu ofanana ndi mawu | Crizotinib Pakati;Crizotinib Bromide Kusayera;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 877399-00-3 |
| Molecular Formula | Chithunzi cha C13H10BrCl2FN2O |
| Kulemera kwa Maselo | 380.04 g / mol |
| Melting Point | 108.0 mpaka 113.0 ℃ |
| Kuchulukana | 1.643 |
| COA & MSDS | Likupezeka |
| Chitsanzo | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | Pakati pa Crizotinib (CAS: 877399-52-5) |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Wachikasu Wopepuka mpaka Wachikasu mpaka Crystal | Zimagwirizana |
| Melting Point | 108.0 mpaka 113.0 ℃ | Zimagwirizana |
| Purity (HPLC Area) | ≥98.0% | 99.1% |
| Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| 1 H NMR Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Izi zayesedwa ndipo zimagwirizana ndi zomwe zafotokozedwa | |
| Shelf Life | Zaka 2 Ngati Zasungidwa Bwino | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
(R) -5-Bromo-3-[1- (2,6-Dichloro-3-Fluorophenyl) ethoxy]pyridin-2-Amine (CAS: 877399-00-3) amagwiritsidwa ntchito ngati pakati pa Crizotinib (CAS: 877399-52-5).
Crizotinib ndithudi ndi mankhwala oletsa khansa kukhala alk (anaplastic lymphoma kinase) ndi ros1 (c-ros oncogene 1) inhibitor, ovomerezeka kuti azichiza ena omwe si ang'onoang'ono a cell lung carcinoma (NSCLC) ku US ndi mayiko ena, ndi ikuchita maphunziro angapo oyesa chitetezo chake komanso mphamvu yake mu anaplastic lalikulu cell lymphoma, neuroblastoma, ndi zotupa zina zapamwamba zolimba mwa akulu ndi ana.
Crizotinib ndi mankhwala ochizira omwe amayang'aniridwa ndi khansa ya m'mapapo yomwe si yaing'ono yopangidwa ndi Pfizer, USA, secorri ndi mankhwala osokoneza bongo komanso opanga nthawi yayitali pantchito yochizira khansa ya m'mapapo.Idavomerezedwa kuti igulidwe ku United States mu Ogasiti 2011 ndipo idalembedwa m'malamulo apadziko lonse a khansa ya m'mapapo kumapeto kwa chaka ngati mankhwala oyamba kwa odwala omwe ali ndi ALK.Co-approved ndi Crizotinib ndiyo njira yoyamba yodziwira majini pogwiritsa ntchito fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, iyi ndi njira yomwe ikugwiritsidwa ntchito panopa m'mayesero achipatala padziko lonse kuti azindikire EML4-ALK fusion gene mu NSCLC.Chiyesochi chidzathandiza kuzindikira odwala omwe angapindule ndi chithandizo cha Crizotinib.
Crizotinib ndi chosankha cha tyrosine kinase receptor inhibitor chomwe chimagwiritsidwa ntchito pochiza matenda osankhidwa a khansa yapakhungu yosakhala yaying'ono yama cell.Ndi awiri a ATP competitive inhibitor a tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ndi ALK (cellular IC50 = 20 nM), onse omwe ali ofunikira kwambiri pamankhwala a khansa.Pamene Crizotinib inayesedwa kuti ikhale yosankha motsutsana ndi kinase ina inapezeka kuti ili ndi enzyme IC50 mkati mwa 100-fold multiples ya c-MET kwa 13 ya 120 kinases yoyesedwa.Poyesa ma cell, Crizotinib idapezeka kuti imaletsa RON (recepteur d'origine nantais) kinase yokhala ndi zenera la 10-fold selectivity pa c-MET.Zonsezi, wothandizirayu amalepheretsa kukula kwa maselo a chotupa.XALKORI®(Crizotinib) ndi mankhwala omwe amagwiritsidwa ntchito pochiza anthu omwe ali ndi khansa yosakhala yaing'ono ya m'mapapo (NSCLC) yomwe yafalikira kumadera ena a thupi ndipo imayamba chifukwa cha vuto la jini yotchedwa ALK (anaplastic lymphoma kinase) kapena jini yotchedwa ROS1.Sizikudziwika ngati XALKORI ndi yotetezeka komanso yothandiza kwa ana.
