1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Purity ≥98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndiwopanga 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) yokhala ndi mawonekedwe apamwamba, apakati a Crizotinib (CAS: 877399- 52-5).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 1-Boc-4- (4-Bromopyrazol-1-yl) piperidine |
| Mawu ofanana ndi mawu | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino) -4-Bromopyrazole;1-Boc-4- (4-Bromo-1-Pyrazolyl) piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl) -1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl) -4-Bromopyrazole;Crizotinib Impurity 4 |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 877399-50-3 |
| Molecular Formula | Chithunzi cha C13H20BrN3O2 |
| Kulemera kwa Maselo | 330.23 g / mol |
| Melting Point | 77.0 mpaka 81.0 ℃ |
| Kuchulukana | 1.43 |
| Kusungunuka | Zosungunuka mu Methanol |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | Pakati pa Crizotinib (CAS: 877399-52-5) |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Zoyera Zolimba | Zoyera Zolimba |
| Melting Point | 77.0 mpaka 81.0 ℃ | Zimagwirizana |
| Madzi ndi Karl Fischer | <0.50% | 0.11% |
| Kuyera / Kusanthula Njira | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Misa | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Zizindikiro Zowopsa Xn - Zowopsa
Zizindikiro Zowopsa 22 - Zowopsa ngati zitamezedwa
1-Boc-4- (4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) imagwiritsidwa ntchito ngati pakati pa Crizotinib (CAS: 877399-52-5).Crizotinib (dzina la malonda Xalkori,) ndi mankhwala oletsa khansa omwe amagwira ntchito ngati ALK (anaplastic lymphoma kinase) ndi ROS1 (c-ros oncogene 1) inhibitor, ovomerezeka kuti azichiza ena omwe si ang'onoang'ono a cell lung carcinoma (NSCLC) ku US. ndi mayiko ena, ndikuyesedwa kwachipatala kuyesa chitetezo ndi mphamvu yake inanaplastic lalikulu cell lymphoma, neuroblastoma, ndi zotupa zina zapamwamba zolimba mwa akulu ndi ana.
Mu Ogasiti 2011, United States FDA idavomereza Crizotinib (PF- 02341066) kuti azichiza anaplastic lymphoma kinase (ALK) yokonzanso khansa ya m'mapapo yopanda maselo ang'onoang'ono (NSCLC).Crizotinib ndi wapawiri ATP competitive inhibitor wa tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50 = 8 nM) ndi ALK (cellular IC50 = 20 nM), zonse zomwe ndizofunikira kwambiri pamankhwala a khansa.Pamene Crizotinib inayesedwa kuti ikhale yosankha motsutsana ndi kinase ina inapezeka kuti ili ndi enzyme IC50 mkati mwa 100-fold multiples ya c-MET kwa 13 ya 120 kinases yoyesedwa.Poyesa ma cell, Crizotinib idapezeka kuti imaletsa RON (recepteur d'origine nantais) kinase yokhala ndi zenera la 10-fold selectivity pa c-MET.
