1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Purity ≥99.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) yokhala ndi mawonekedwe apamwamba, apakati a Crizotinib (CAS: 877399-52) -5).Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | 1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole |
| Mawu ofanana ndi mawu | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Crizotinib Impurity 16 |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 877399-73-0 |
| Molecular Formula | C13H20IN3O2 |
| Kulemera kwa Maselo | 377.22 g / mol |
| Melting Point | 97℃ |
| Kuchulukana | 1.60±0.10 g/cm3 |
| Zomverera | Kuwala Kumverera |
| Kusungirako Temp. | 2 ~ 8 ℃, Tetezani Kuwala |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Gulu | Pakati pa Crizotinib (CAS: 877399-52-5) |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Yoyera mpaka Yowala Yellow Yolimba | Zoyera Zolimba |
| Kuyera / Kusanthula Njira | ≥99.0% (HPLC) | 99.58% |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| 1 H NMR Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| ESI+ | Zimagwirizana | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) yokhala ndi khalidwe lapamwamba, lapakati la Crizotinib (CAS: 877399-52-5).Crizotinib ndi mankhwala ochizira omwe amayang'aniridwa ndi khansa ya m'mapapo yomwe si yaing'ono yopangidwa ndi Pfizer, USA, secorri ndi mankhwala osokoneza bongo komanso opanga nthawi yayitali pantchito yochizira khansa ya m'mapapo.Idavomerezedwa kuti igulidwe ku United States mu Ogasiti 2011 ndipo idalembedwa m'malamulo apadziko lonse a khansa ya m'mapapo kumapeto kwa chaka ngati mankhwala oyamba kwa odwala omwe ali ndi ALK.Co-approved ndi Crizotinib ndiyo njira yoyamba yodziwira majini pogwiritsa ntchito fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, iyi ndi njira yomwe ikugwiritsidwa ntchito panopa m'mayesero achipatala padziko lonse kuti azindikire EML4-ALK fusion gene mu NSCLC.Chiyesochi chidzathandiza kuzindikira odwala omwe angapindule ndi chithandizo cha Crizotinib.pa 25, awa ndi mankhwala oyamba omwe amagwiritsidwa ntchito pochiza odwala omwe ali ndi khansa ya m'mapapo yapamwamba kapena metastatic non-small cell lung cancer (NSCLC) yomwe ndi anaplastic lymphoma kinase (ALK) -positive monga momwe zatsimikiziridwa ndi kuyesa kovomerezeka ndi SFDA.
Crizotinib (PF-02341066) Crizotinib ndi c-Met ndi ALK inhibitor yamphamvu, ma IC50 mu cell assay anali 11 nM ndi 24 nM, motero.Ilinso inhibitor yamphamvu ya ROS1 yokhala ndi mtengo wa Ki wochepera 0.025 nM.Crizotinib imatha kuyambitsa autophagy mumitundu yosiyanasiyana ya khansa ya m'mapapo poletsa njira ya STAT3.
