CAS 945667-22-1 Purity>99.0% (HPLC) API

Kufotokozera Kwachidule:

CAS: 945667-22-1

Kuyera: > 99.0% (HPLC)

Maonekedwe: Ufa Woyera

API, High Quality, Commercial Production

E-Mail: alvin@ruifuchem.com

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Kufotokozera:

Ruifu Chemical Supply Related Intermediates
Chithunzi cha CAS 361442-04-8
CAS 945667-22-1
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(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
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(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Mawu ofanana ndi mawu	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S) -2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2--[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Nambala ya CAS	945667-22-1
Nambala ya CAT	RF-PI1992
Stock Status	Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula	C18H25N3O2·H2O
Kulemera kwa Maselo	333.43
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera
chizindikiritso	A: IR B: HPLC Retention Time
Kuyera / Kusanthula Njira	> 99.0% (HPLC, On Dried Basis)
M'madzi (KF)	5.3% ~ 7.3%
Zotsalira pa Ignition	<0.20%
Chidetso Chimodzi	<0.50%
Zonse Zonyansa	<1.00%
Zitsulo Zolemera	<10ppm
Arsenic (As)	<2ppm
Microbiology
Total Plate Count	<1000cfu/g
Yisiti & Mold	<100cfu/g
E. Coli	Zoipa
S. Aureus	Zoipa
Salmonella	Zoipa
Shelf Life	Miyezi 24
Test Standard	Enterprise Standard
Kugwiritsa ntchito	API;Amagwiritsidwa Ntchito Pochiza Matenda a Type II Diabetes

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi

Ubwino:

FAQ:

Ntchito:

API (CAS: 945667-22-1) ndi choletsa chosankha komanso chosinthika cha dipeptidyl peptidase-4 (DPP4) chomwe chingagwiritsidwe ntchito popanga chithandizo cha matenda amtundu wa 2.Ndizosankha komanso zosinthika DPP4 inhibitor yokhala ndi IC50 ya 26 nM ndi Ki ya 1.3 nM.IC50 mtengo: 26 nM.Chandamale: DPP4 in vitro: Ili ndi inhibition yokhazikika ya Ki ya 1.3 nM ya DPP4 inhibition, yomwe ili yamphamvu kuwirikiza ka 10 kuposa Sitagliptin (ma inhibitors ena awiri a DPP4) okhala ndi Ki wa 13 ndi 18 nM.Kuphatikiza apo, Imawonetsa kutsimikizika kwakukulu kwa DPP4 kuposa ma enzymes a DPP8 kapena DPP9 (400- ndi 75-fold, motsatana).Metablite yake yogwira imakhala yowirikiza kawiri kuposa kholo.Onse (CAS: 945667-22-1) ndi metabolite yake imasankha kwambiri (> 4000-fold) pofuna kupewa DPP4 poyerekeza ndi ma protease ena ambiri.(CAS: 945667-22-1) amachepetsa kuwonongeka kwa incretin hormone glucagon-like peptide-1, potero imapangitsa kuti zochita zake zitheke, ndipo zimagwirizanitsidwa ndi ntchito yabwino ya β-cell ndi kupondereza kwa glucagon secretion.in vivo: Ndiwothandiza kwambiri pakufuna kuwonjezereka kodalira kwa mlingo wa kuvomerezeka kwa shuga mu mlingo wa 0.13-1.3 mg/kg pa mbewa za ob/ob mogwirizana ndi zowongolera.