4-Chloro-6-Iodoquinazoline CAS 98556-31-1 Chiyero>98.0% (HPLC)

4-Chloro-6-Iodoquinazoline (CAS: 98556-31-1) ndi yapakatikati mwa kaphatikizidwe ka Lapatinib (CAS: 231277-92-2) / Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8).
Lapatinib ndi mankhwala atsopano a khansa ya m'mawere omwe amathandizidwa ndi mankhwala opangidwa ndi GlaxoSmithKline, omwe adavomerezedwa ndi US Food and Drug Administration pa March 13, 2007. Chizindikiro chovomerezeka panopa chikuphatikizidwa ndi capecitabine ya khansa ya m'mawere yapamwamba kapena ya metastatic, ndi odwala khansa ya m'mawere. ayenera kuthandizidwa ndi mankhwala ena oyamba.Dzina lake lamalonda ku United States ndi Tykerb.Pa Disembala 14, 2007, European Medicines Agency (EMEA) idavomereza kulembedwa kwa Lapatinib ku Europe pansi pa dzina la malonda Tyverb.Thandizo la mamolekyulu la khansa ya m'mawere limatanthawuza kuchiza ma oncogene ndi zinthu zina zokhudzana ndi zomwe zimachitika komanso kukula kwa khansa ya m'mawere.Mankhwala omwe amapangidwa ndi mamolekyulu amaletsa kapena kupha ma cell chotupa poletsa kutulutsa kwa ma cell m'ma cell chotupa kapena ma cell ofananira nawo kuti athe kuwongolera kusintha kwa jini.Lapatinib ndi pakamwa kakang'ono ka molekyulu epidermal kukula factor tyrosine kinase inhibitor.Mayesero azachipatala awonetsa kuti kwa odwala khansa ya m'mawere ya HER2 omwe ayamba kukana Roche's Herceptin (Herceptin), Lapatinib ili ndi zotsatira zabwino zachipatala.Mayeso a in vitro, Lapatinib anali ndi vuto lalikulu loletsa kukula kwa Her-2 overexpressing cell cancer cell cell.M'mayesero a Gawo I a khansa ya m'mawere yapamwamba ndi Her-2 overexpression, Lapatinib ilinso ndi mlingo wothandiza kwambiri ndipo ilibe kutsutsana ndi Herceptin (trastuzumab).Chifukwa kapangidwe kake ndi kamolekyu kakang'ono, mosiyana ndi Herceptin (trastuzumab), imatha kulowa chotchinga chamagazi-muubongo ndipo imakhala ndi chithandizo chamankhwala muubongo metastasis ya khansa ya m'mawere.