Chloramphenicol CAS 56-75-7 Purity ≥99.0% (HPLC) High Purity
Wopanga Wopanga Ndi Ukhondo Wapamwamba ndi Kupanga Zamalonda
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
Dzina la Chemical | Chloramphenicol |
Mawu ofanana ndi mawu | D-(-)-threo-2-Dichloroacetamido-1- (4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
Nambala ya CAS | 56-75-7 |
Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
Molecular Formula | C11H12Cl2N2O5 |
Kulemera kwa Maselo | 323.13 |
Melting Point | 149.0 mpaka 153.0 ℃ (lit.) |
Zomverera | Kuwala Kumverera |
Kusungunuka | Zosungunuka kwambiri mu Ethanol, Methanol, Acetone.Zosungunuka mu Ether, Chloroform.Insoluble ku Benzene.Zosasungunuka m'madzi |
Mkhalidwe Wotumiza | Kutumizidwa Pansi pa Kutentha Kozungulira |
COA & MSDS | Likupezeka |
Chiyambi | Shanghai, China |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Woyera mpaka Kuwala Wachikasu |
Chizindikiro A | Mayamwidwe a infrared |
Chizindikiro B | Nthawi yosungira pachimake chachikulu mu chromatogram ya kukonzekera kwa Assay ikufanana ndi yomwe ili mu chromatogram ya Kukonzekera kwa Standard, monga momwe idapezedwa mu Assay. |
Specific Optical Rotation | +17.0°~+20.0° |
Melting Point | 149.0 ~ 153.0 ℃ |
Crystallinity | Imakwaniritsa Zofunikira |
pH | 4.5-7.5 |
Chidetso Chimodzi | ≤0.50% |
Zonse Zonyansa | ≤1.00% |
Zitsulo Zolemera | ≤20ppm |
Arsenic | ≤1ppm |
Kutaya pa Kuyanika | ≤0.50% (105 ℃, maola 3) |
Zotsalira pa Ignition | ≤0.10% |
Kuyera / Kusanthula Njira | ≥99.0% (HPLC) |
Test Standard | Enterprise Standard;JP;USP |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Chloramphenicol ili ndi zosachepera 97.0 peresenti komanso zosaposa 103.0 peresenti ya C11H12Cl2N2O5.
Kupaka ndi kusunga-Sungani zotengera zothina.
Kulembera -Kumene kuyenera kugwiritsidwa ntchito popanga jekeseni kapena mitundu ina ya jekeseni wosabala, chizindikirocho chimanena kuti ndi wosabala kapena chiyenera kukonzedwanso panthawi yokonzekera jekeseni kapena mitundu ina ya jekeseni wosabala.
Miyezo yolozera ya USP <11>-
USP Chloramphenicol RS Dinani kuti muwone Kapangidwe
USP Endotoxin RS
Chizindikiritso-
A: Infrared mayamwidwe <197K>.
B: Nthawi yosungira pachimake chachikulu mu chromatogram ya Kukonzekera kwa Assay ikufanana ndi yomwe ili mu chromatogram ya Kukonzekera kwa Standard, monga momwe zapezedwa mu Assay.
Kusungunuka <741>: pakati pa 149 ndi 153.
Kusinthasintha kwachindunji <781S>: pakati pa +17.0 ndi +20.0.
Njira yothetsera mayeso: 50 mg, osawumitsidwa, pa mL, mu mowa wopanda madzi.
Crystallinity <695>: imakwaniritsa zofunikira.
Mabakiteriya endotoxins 85-Kumene Chloramphenicol amapangidwira kuti agwiritsidwe ntchito pokonzekera mafomu a jekeseni, imakhala ndi 0.2 USP Endotoxin Unit pa mg wa chloramphenicol.
Sterility 71- Kumene lebulo likunena kuti Chloramphenicol ndi yobala, imakwaniritsa zofunikira ikayesedwa monga momwe zalembedwera Kusefera kwa Membrane pansi pa Kuyesedwa kwa Kusabereka kwa Zinthu kuti Kuwunikidwe, kupatula kugwiritsa ntchito 1 g ya chitsanzo cholimba.
pH <791>: pakati pa 4.5 ndi 7.5, mu kuyimitsidwa kwamadzi komwe kuli 25 mg pa mL.
Chromatographic purity-Sungani mlingo woyezera bwino wa Chloramphenicol mu methanol kuti mupeze njira yoyesera yomwe ili ndi 10 mg pa mL.Konzani njira yothetsera USP Chloramphenicol RS mu methanol yokhala ndi 10 mg pa mL (Standard solution A).Sungunulani magawo a Standard solution A mochulukira ndi methanol kuti mupeze yankho lokhazikika B lomwe lili ndi 100 µg pa mL ndi njira yokhazikika C yokhala ndi 50 µg pa mL.Ikani magawo osiyana a 20-µL a yankho loyesa ndi mayankho Okhazikika B ndi C ku mbale yoyenera yopyapyala yopyapyala (onani Chromatography 621), yokutidwa ndi wosanjikiza wa 0.25-mm wa chromatographic silika gelisi osakaniza.Pangani chromatogram mu zosungunulira zokhala ndi chloroform, methanol, ndi glacial acetic acid (79:14:7) mpaka kutsogolo kwa zosungunulira kusuntha pafupifupi magawo atatu mwa anayi a utali wa mbaleyo.Chotsani mbaleyo mchipindacho, chowuma, ndikuwunika pansi pa kuwala kwa UV kwaufupi: malo aliwonse kupatulapo malo oyambira omwe atengedwa kuchokera ku yankho la mayeso sadutsa kukula kapena kulimba kwa malo oyamba omwe atengedwa ku Standard solution B (1% ), ndi kuchuluka kwa zonyansa zomwe zimayimiridwa ndi madontho onse kupatulapo malo oyamba, kutengera kulimba kwa malo oterowo ndi kulimba kwa mawanga akuluakulu opezeka ku Standard Solutions B ndi C, sikudutsa 2% .
Kuyesa-
Mobile phase-Konzani osakaniza oyenera osefedwa madzi, methanol, ndi glacial acetic acid (55:45:0.1).Sinthani ngati kuli kofunikira (onani Kukwanira Kwadongosolo pa Chromatography 621).
Kukonzekera kokhazikika- Sungunulani kuchuluka kwake koyezedwa bwino kwa USP Chloramphenicol RS mu gawo la Mobile, ndikuchepetsa mochulukira, komanso pang'onopang'ono ngati kuli kofunikira, ndi gawo la Mobile kuti mupeze yankho lomwe lili ndi ndende yodziwika pafupifupi 80 µg pa mL.Sefa gawo lina la yankholi kudzera mu fyuluta ya 0.5-µm kapena porosity yabwino kwambiri, ndipo gwiritsani ntchito kusefera komveka bwino monga kukonzekera Kwanthawi zonse.
Kukonzekera kuyesa- Tumizani pafupifupi 200 mg ya Chloramphenicol, yoyezedwa molondola, ku botolo la volumetric 100-mL, kuwonjezera gawo la Mobile ku voliyumu, ndikusakaniza.Tumizani 4.0 mL ya yankho ku botolo la volumetric 100-mL, tsitsani ndi gawo la Mobile mpaka voliyumu, ndikusakaniza.Sefa gawo lina la yankholi kudzera mu fyuluta ya 0.5-µm kapena porosity yabwino kwambiri, ndipo gwiritsani ntchito kusefa komveka bwino monga kukonzekera Assay.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 280-nm ndi ndime ya 4.6-mm × 10-cm yomwe ili ndi 5-µm packing L1.Kuthamanga kwa madzi ndi pafupifupi 1 ml pa mphindi.Chromatograph the Standard kukonzekera, ndikujambulitsa mayankho apamwamba monga momwe adayankhidwira mu Ndondomeko: magwiridwe antchito omwe amatsimikiziridwa kuchokera pachimake cha analyte sichochepera 1800 mbale zongoyerekeza, chinthu chamchira sichikupitilira 2.0, ndipo kupatuka kwachibale kwa jakisoni wobwereza sikuli. kuposa 1.0%.
Ndondomeko--[chidziwitso-Gwiritsani ntchito nsonga zapamwamba pomwe mayankho apamwamba akuwonetsedwa.] Lowetsani padera ma voliyumu ofanana (pafupifupi 10 µL) a Kukonzekera kwa Standard ndi kukonzekera kwa Assay mu chromatograph, lembani ma chromatogram, ndi kuyeza mayankho a nsonga zazikulu.Werengetsani kuchuluka, mu mg, wa C11H12Cl2N2O5 mu gawo la Chloramphenicol lotengedwa ndi chilinganizo:
2.5C(rU / rS)
momwe C ndi ndende, mu µg pa mL, ya USP Chloramphenicol RS mu Kukonzekera Kwanthawi zonse, ndipo rU ndi rS ndiwo mayankho apamwamba omwe apezedwa kuchokera ku Kukonzekera kwa Assay ndi kukonzekera Kwanthawi zonse, motsatana.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
Chloramphenicol ili ndi osachepera 980 mg (potency) komanso osapitirira 1020 mg (potency) pa mg, owerengedwa pa zouma.Mphamvu ya Chloramphenicol imawonetsedwa ngati misa (potency) ya chloramphenicol (C11H12Cl2N2O5).
Kufotokozera Chloramphenicol imapezeka ngati yoyera mpaka yoyera, yonyezimira kapena ufa wonyezimira.
Amasungunuka momasuka mu methanol ndi ethanol (99.5), ndipo amasungunuka pang'ono m'madzi.
Kuzindikiritsa (1) Dziwani kuchuluka kwa mayamwidwe a yankho lachitsanzo lomwe linapezedwa mu Assay monga momwe limayankhidwira pansi pa Ultraviolet-visible Spectrophotometry <2.24>, ndikuyerekeza mawonekedwe ndi Reference Spectrum kapena sipekitiramu ya yankho la Chloramphenicol RS yokonzedwa mofanana ndi yankho lachitsanzo: mawonekedwe onsewa amawonetsa kuyamwa kofananira pamafunde omwewo.
(2) Dziwani kuchuluka kwa mayamwidwe a infrared a Chloramphenicol monga momwe amachitira mu njira ya potassium bromide disk pansi pa Infrared Spectrophotometry <2.25>, ndipo yerekezerani sipekitiramu ndi Reference Spectrum kapena sipekitiramu ya Chloramphenicol RS: mawonekedwe onsewa amawonetsa kulimba kofanana kwa kuyamwa komweko. manambala a mafunde.
Kuzungulira kwa kuwala <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Malo osungunuka <2.60> 150 ~ 155 ℃
Kuyera (1) Zitsulo zolemera <1.07>-Pitirizani ndi 1.0 g ya Chloramphenicol molingana ndi Njira 2, ndikuyesani.Konzani njira yowongolera ndi 2.5 mL ya Standard Lead Solution (osapitirira 25 ppm).
(2) Arsenic <1.11> -Konzani njira yothetsera mayesero ndi 2.0 g ya Chloramphenicol molingana ndi Njira 4, ndikuchita mayeso (osapitirira 1 ppm).
(3) Zinthu zogwirizana-Sungani 0,10 g ya Chloramphenicol mu 10 ml ya methanol, ndipo gwiritsani ntchito njira iyi ngati njira yothetsera.Pipeni 1 ml ya yankho lachitsanzo, onjezerani methanol kuti mupange ndendende 100 ml, ndipo gwiritsani ntchito yankholi ngati yankho lokhazikika (1).Pipeti 10 ml ya yankho lokhazikika (1), onjezerani methanol kuti mupange 20 ml ndendende, ndipo gwiritsani ntchito yankholi ngati yankho lokhazikika (2).Chitani mayeso ndi mayankho awa monga momwe akuwongolera pansi pa Thin-layer Chromatography <2.03>.Malo 20 ml iliyonse ya yankho lachitsanzo ndi njira zokhazikika (1) ndi (2) pa mbale ya silika gel osakaniza ndi fulorosenti chizindikiro cha woonda wosanjikiza chromatography, kupanga mbale ndi osakaniza chloroform, methanol ndi asidi asidi (100) ( 79:14:7) mpaka mtunda wa pafupifupi 15 cm, ndi kuumitsa mbale.Yang'anani pansi pa kuwala kwa ultraviolet (mafunde aakulu: 254 nm): madontho ena kupatulapo malo oyambirira ndi malo omwe adatengedwa kuchokera ku yankho lachitsanzo sali ochuluka kuposa malo omwe amachokera ku njira yokhazikika (1), ndi chithumwa chonse. mwa mawanga awa kuchokera ku yankho lachitsanzo si opitilira 2.0%.
Kutaya pa kuyanika <2.41> Osapitirira 0.5% (1 g, 105 ℃, 3 hours).
Zotsalira pakuyatsa <2.44> Osapitirira 0.1%(1 g).
Kuyesa Kuyeza molondola kuchuluka kwa Chloramphenicol ndi Chloramphenicol RS, zofanana ndi pafupifupi 0.1 g (potency), sungunulani iliyonse mu 20 mL ya methanol, ndi kuwonjezera madzi kuti apange 100 mL ndendende.Pipeni 20 ml iliyonse mwa njirazi, ndikuwonjezera madzi kuti mupange 100 ml ndendende.Pipeni 10 ml iliyonse mwa njirazi, onjezerani madzi kuti mupange 100 ml ndendende, ndipo gwiritsani ntchito njirazi ngati njira yothetsera chitsanzo ndi yankho lokhazikika.Tsimikizirani zotengera, AT ndi AS, pa 278 nm yachitsanzo chachitsanzo ndi yankho lokhazikika monga momwe amachitira ndi Ultraviolet-visible Spectrophotometry <2.24>.
Kuchuluka [mg (potency)] kwa chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Kuchuluka [mg (potency)] kwa Chloramphenicol RS
kutengedwa
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Zizindikiro Zowopsa R45 - Zingayambitse khansa
R11 - Yoyaka Kwambiri
R39/23/24/25 -
R23/24/25 - Poizoni pokoka mpweya, kukhudzana ndi khungu komanso kumeza.
Kufotokozera Zachitetezo S53 - Pewani kuwonekera - pezani malangizo apadera musanagwiritse ntchito.
S45 - Pakachitika ngozi kapena ngati simukumva bwino, funsani upangiri wachipatala nthawi yomweyo (onetsani chizindikirocho ngati kuli kotheka.)
S16 - Khalani kutali ndi magwero oyatsira.
S36/37 - Valani zovala zoteteza ndi magolovesi oyenera.
Ma ID a UN 2811
WGK Germany 3
RTECS AB6825000
FLUKA BRAND F MAKODI 3-10
TSCA Inde
HS kodi 2941400000
Kalasi Yowopsa 3
Poizoni LD50 pakamwa pa makoswe: 2500mg/kg
P501: Taya zamkati / chidebe kumalo ovomerezeka otaya zinyalala.
P260: Osapumira fumbi/ fume/ gasi/ nkhungu/ nthunzi/ utsi.
P270: Osadya, kumwa kapena kusuta mukamagwiritsa ntchito mankhwalawa.
P202: Osagwira ntchito mpaka njira zonse zotetezera zitawerengedwa ndikumveka.
P201: Pezani malangizo apadera musanagwiritse ntchito.
P264: Tsukani khungu bwinobwino mukachigwira.
P280: Valani magolovesi oteteza / zovala zoteteza / zoteteza maso / zoteteza kumaso.
P308 + P313: NGATI zawululidwa kapena kukhudzidwa: Pezani upangiri wachipatala/ chisamaliro.
P405: Sitolo yotsekedwa.
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapereka Chloramphenicol (CAS: 56-75-7) ndi apamwamba kwambiri.Chloramphenicol ndi yotakata sipekitiramu antibacterial maantibayotiki, amene ali woyamba kusankha zochizira tayifodi ndi paratyphoid, kachiwiri, ntchito zochizira matenda osiyanasiyana opatsirana chifukwa tcheru tizilombo.Chifukwa chachikulu chokhwima zochita tsopano ntchito mochepa.The antibacterial sipekitiramu, ntchito ndi ntchito ndi chimodzimodzi monga chloramphenicol zochizira Salmonella Typhi, Shigella, Escherichia coli, fuluwenza, Brucella, chibayo matenda chifukwa cocci ndi mankhwala ena anti-infective mankhwala.Chloramphenicol amagwiritsidwa ntchito makamaka pochiza matenda a mkodzo, chibayo, matenda a m'mimba ndi septicemia yoyambitsidwa ndi mabakiteriya okhudzidwa, komanso madontho akunja a maso ndi madontho a khutu.
UN3249 Mankhwala, olimba, owopsa, ayi, Kalasi Yowopsa: 6.1;Zolemba: 6.1-Zinthu zapoizoni.UN2811 Zolimba zapoizoni, organic, nos, Kalasi Yowopsa: 6.1;Zolemba: 6.1- Zida zapoizoni, Dzina Laumisiri Lofunika.