D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga D-(+)-Cycloserine (CAS: 68-41-7) ndi apamwamba kwambiri.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, zochepa komanso zochulukirapo zomwe zilipo.Gulani D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | D-(+)-Cycloserine |
| Mawu ofanana ndi mawu | D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;Orientomycin;Oxamycin;α-Cycloserine |
| Stock Status | Zilipo |
| Nambala ya CAS | 68-41-7 |
| Molecular Formula | Chithunzi cha C3H6N2O2 |
| Kulemera kwa Maselo | 102.09 g / mol |
| Melting Point | 137 ℃ |
| Zomverera | Simamva Kutentha, Kutentha |
| Kusungunuka | Zosungunuka mu Madzi.Kusungunuka pang'ono mu Methanol ndi Propylene Glycol.Zosasungunuka mu Chloroform ndi Ether. |
| Kusungirako Temp. | Malo Ozizira & Owuma (2~8℃) |
| COA & MSDS | Likupezeka |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Woyera kapena Wotuwa Wachikaso Wakristalo | Zimagwirizana |
| Kusinthasintha Kwachindunji [α]20/D | +108.0° mpaka +114.0° (C=5, 2N NaOH) | + 111.9 ° |
| Chizindikiritso | Mtundu Wabuluu Unakula Pang'onopang'ono | Mtundu Wabuluu |
| Condensation Products | ≤0.80% (pa 286nm) | 0.08% |
| Kutaya pa Kuyanika | <1.00% | 0.38% |
| Zotsalira pa Ignition | <0.50% | 0.10% |
| Zitsulo Zolemera (Pb) | ≤10ppm | <10ppm |
| Chidetso Chosakhazikika | ||
| - Methanol | ≤500ppm | <500ppm |
| - Acetone | ≤500ppm | <500ppm |
| Kuyesa (Maantibayotiki-Microbial Assay) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 mpaka 6.5 | 5.98 |
| FTIR | Zimagwirizana | Zimagwirizana |
| IR Spectrum | Zimagwirizana | Zimagwirizana |
| Chithunzi cha NMR | Zimagwirizana | Zimagwirizana |
| Mapeto | Chogulitsachi pochiwunika chimagwirizana ndi USP-35 wamba | |
Cycloserine [68-41-7].
Cycloserine ili ndi mphamvu yosachepera 900µg ya C3H6N2O2 pa mg.
Kupaka ndi kusunga-Sungani zotengera zothina.
Miyezo yolozera ya USP <11>-
USP Cycloserine RS
Chizindikiritso-Sungani za 1 mg mu 10 mL wa 0.1 N sodium hydroxide.Pa 1 ml ya yankho, onjezerani 3 mL wa 1 N acetic acid ndi 1 mL ya osakaniza, okonzeka ola limodzi musanagwiritse ntchito, magawo ofanana a sodium nitroprusside solution (1 mu 25) ndi 4 N sodium hydroxide: mtundu wa buluu pang'onopang'ono. akukula.
Condensation products-Kumayamwa kwake (onani Spectrophotometry ndi Light-Scattering <851>) pa 285 nm, yotsimikiziridwa mu 0.1 N sodium hydroxide solution yomwe ili ndi 0.40 mg pa mL siposa 0.80.
Kuzungulira kwachindunji <781S>: pakati pa 108 ° ndi 114 °.Njira yothetsera mayeso: 50 mg pa mL, mu 2 N sodium hydroxide.
Crystallinity <695>: imakwaniritsa zofunikira
pH <791>: pakati pa 5.5 ndi 6.5, mu yankho (1 mu 10).
Kutaya pakuyanika <731>-Unikani pafupifupi 100 mg mu botolo la capillar y-stoppered mu vacuum pa 60 ℃ kwa maola atatu: imataya osapitirira 1.0% ya kulemera kwake.
Zotsalira pakuyatsa <281>: osapitirira 0.5%, zotsalira zoyaka zimanyowa ndi 2 ml ya nitric acid ndi madontho asanu a sulfuric acid.
Kuyesa-
pH 6.8 Phosphate buffer-Konzekerani monga momwe mukufunira mu Buffer Solutions pansi pa Mayankho mu gawo la Reagents, Indicators, and Solutions.
Mobile phase-Sungani 0.5 g ya sodium 1-decanesulfonate mu 800 ml ya madzi, kuwonjezera 50 mL acetonitrile ndi 5 mL wa glacial acetic acid, ndi kusakaniza.Sinthani ndi 1 N sodium hydroxide kukhala pH ya 4.4.Zosefera, ndi degas.Sinthani ngati kuli kofunikira y (onani Kuyenerera Kwadongosolo pansi pa Chromatography <621>).
Kukonzekera kokhazikika - Sungunulani kuchuluka kwake koyezera kolondola kwa USP Cycloserine RS mu pH 6.8 Phosphate buffer kuti mupeze yankho lodziwika bwino la 0.4 mg pa ml.
Kukonzekera koyesa-Kutumiza pafupifupi 20 mg ya Cycloserine, yoyezedwa molondola, ku botolo la volumetric 50-mL, sungunulani ndi kusungunula ndi pH 6.8 Phosphate buffer ku voliyumu, ndi kusakaniza.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 219-nm ndi ndime ya 4.6-mm × 25-cm yomwe ili ndi 5- µm yonyamula L1.Kuthamanga kwa madzi ndi pafupifupi 1 ml pa mphindi.Kutentha kwa mzati kumasungidwa pafupifupi 30 °.Chromatograph the Standard kukonzekera, ndikujambulitsa mayankho apamwamba monga momwe adayankhidwira Ndondomeko: chinthu chotsalira sichiposa 1.8;ndipo kupatuka kofanana kwa jakisoni wobwereza sikudutsa 2.0%.
Kachitidwe-Papatula jekeseni ma voliyumu ofanana (pafupifupi 10 µL) a Kukonzekera Kwanthawi zonse ndi kukonzekera kwa Assay mu chromatograph, lembani ma chromatogram, ndikuyesa mayankho apamwamba a cycloserine.Werengetsani kuchuluka, mu µg, wa C3H6N2O2 mu mg uliwonse wa Cycloserine wotengedwa ndi formula:
50,000(C/W)(rU / rS)
momwe C ndi ndende, mu mg pa mL, wa USP Cycloserine RS mu kukonzekera Standard;W ndi kuchuluka, mu mg, wa Cycloserine wotengedwa kukonzekera kukonzekera Assay;ndi rU ndi rS ndiwo mayankho apamwamba a cycloserine omwe atengedwa kuchokera ku Assay kukonzekera ndi kukonzekera Standard, motsatana.
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yomata pamalo ozizira komanso owuma (2~8 ℃) kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Zizindikiro Zowopsa Xn - Zowopsa
Zizindikiro Zowopsa
R5 - Kutentha kungayambitse kuphulika
R20 - Zowopsa pokoka mpweya
Kufotokozera Zachitetezo
S38 - Ngati mulibe mpweya wokwanira, valani zida zoyenera zopumira.
S36/37 - Valani zovala zoteteza ndi magolovesi oyenera.
S24/25 - Pewani kukhudzana ndi khungu ndi maso.
WGK Germany 2
Mtengo wa RTECS NY2975000
FLUKA BRAND F MAKODI 10-23
HS kodi 2941909099
D-(+)-Cycloserine (CAS: 68-41-7) ili ndi chikhalidwe champhamvu cha hygroscopic, imasungunuka m'madzi, imasungunuka pang'ono mu zakumwa zoledzeretsa, acetone ndi dioxane, ndipo sizisungunuka mu chloroform ndi petroleum ether.Ndiwokhazikika mu njira ya alkaline ndipo amawola mofulumira mu njira za acidic kapena zandale.Monga maantibayotiki ambiri, cycloserine imalepheretsa mabakiteriya ambiri a Gram-positive ndi Gram-negative, rickettsia ndi protozoa, kupatula Mycobacterium TB. vinactane para-aminosalicylic acid, isoniazid ndi pyrazinamide.Cycloserine imalumikizana pang'ono ndi isoniazid poletsa Mycobacterium tuberculosis H37RV, koma simalumikizana kapena kutsutsana ndi streptomycin.Chogulitsacho ndi bacteriostatic agent, motero sichikhala ndi mphamvu ya bactericidal ngakhale mukamawonjezera mlingo kapena kutalikitsa nthawi yogwira ntchito ndi mabakiteriya.
Njira ya antibacterial ya D-cycloserine ndikuletsa biosynthesis ya peptidoglycan ya khoma la cell.Popeza ndi analogue ya D-alanine, D-cycloserine imatha kulepheretsa ntchito za alanine racemase ndi D-alanyl-D-alanine synthetase, omwe ndi ma enzyme awiri ofunikira mu kaphatikizidwe ka peptidoglycan.D-cycloserine imawonetsa ntchito yofooka yoletsa motsutsana ndi Mycobacterium tuberculosis yomwe ili 1/10 mpaka 1/20 yokha ya streptomycin.Ubwino wa mankhwalawa ndikuti umagwira ntchito pamtundu wa chifuwa chachikulu cha Mycobacterium chosamva mankhwala ndipo sichimayambitsa kukana mankhwala.Mankhwalawa angagwiritsidwe ntchito ndi mankhwala ena odana ndi chifuwa chachikulu cha TB pochiza chifuwa chachikulu cha chifuwa chachikulu cha chifuwa chachikulu cha Mycobacterium TB chosamva mankhwala.
Cycloserine ndi mzere wachiwiri wotsutsa chifuwa chachikulu.Ikhoza kulepheretsa kukula kwa chifuwa chachikulu cha Mycobacterium, koma zotsatira zake zimakhala zofooka kusiyana ndi mankhwala a mzere woyamba.Mphamvu yake mu chithandizo cha chifuwa chachikulu ndi yochepa.Kugwiritsa ntchito mankhwalawa kokha kungabweretse kukana kwa mankhwala, koma kukana kumachitika pang'onopang'ono poyerekeza ndi mankhwala ena oletsa chifuwa chachikulu.Palibe kutsutsana pakati pa cycloserine ndi mankhwala ena odana ndi chifuwa chachikulu.Limagwirira ake antibacterial kanthu ndi ziletsa kaphatikizidwe wa peptidoglycan wa bakiteriya cell khoma, kuchititsa zosalongosoka mu cell khoma zomangamanga.Chigawo chachikulu cha khoma la bakiteriya cell ndi peptidoglycan, yomwe imapangidwa ndi N-acetylglucosamine (GNAc) ndi N-acetylmuramic acid (MNAc).N-acetylmuramic acid imalumikizidwa ndi pentapeptide ndipo imalumikiza N-acetylglucosamine mobwerezabwereza komanso njira ina.Mapangidwe a cytoplasmic peptidoglycan precursor akhoza kusokonezedwa ndi cycloserine, chifukwa chotsirizirachi chingalepheretse racemase ndi synthetase ya D-Alanine, motero amalepheretsa mapangidwe a N-acetylmuramic acid.
D-Cycloserine ikhoza kupezeka kudzera mu njira yowotchera kapena kudzera mu kaphatikizidwe kachindunji.Mabakiteriya omwe amagwiritsidwa ntchito powotchera ndi Actinomyces laven-dulae.Sing'anga yowotchera imakhala ndi dextrin, dextrose, wowuma, ufa wa soya, ufa wa yisiti, ammonium sulfate, ammonium nitrate, calcium carbonate, sodium chloride, magnesium sulfate ndi mafuta a soya.Mu kaphatikizidwe kachitidwe, D-Cycloserine imapezeka kuchokera ku β-Aminooxy alanine ethyl ester hydrochloride pochita ndi potaziyamu hydroxide mu cyclization reaction.
