Daptomycin CAS 103060-53-3 Purity ≥95.0% API Factory High Purity

Daptomycin (CAS: 103060-53-3) ndi mtundu wa maantibayotiki a cyclic lipopeptide okhala ndi mawonekedwe atsopano.Amachokera ku msuzi wa Streptomyces fermentation.Idapezedwa ndi Eli Lilly Company mu 1980s, ndipo idapangidwa bwino mu 1997 ndi Cubist Pharmaceuticals.Sikuti imakhala ndi kapangidwe kake kake kake, komanso imakhala ndi machitidwe omwe ndi osiyana ndi maantibayotiki aliwonse omwe adavomerezedwa kale: imalepheretsa ma cell ndikusokoneza kayendedwe ka amino acid kudzera mu cell membrane, potero imatsekereza cell wall peptidoglycan biosynthesis ndikusintha mawonekedwe a cell. cell membrane.Itha kuwononga ntchito ya cell ya bakiteriya m'njira zambiri, ndikupha mwachangu mabakiteriya a gram-positive.Kuphatikiza pa kugwira ntchito kwa mabakiteriya omwe ali ndi gramu, chofunika kwambiri n'chakuti Daptomycin ili ndi mphamvu zochizira tizilombo toyambitsa matenda tomwe tasonyeza zizindikiro za kukana methicillin, vancomycin ndi linezolid.Katunduyu ndi wofunikira kwambiri kwa odwala omwe ali ndi matenda oopsa.Mu September 2003, US Food and Drug Administration inavomereza kwa nthawi yoyamba kuti Daptomycin (CAS: 103060-53-3) agwiritsidwe ntchito pochiza matenda aakulu a khungu.Mu Marichi 2006, idavomerezedwa pochiza matenda opatsirana.Mu Januwale 2006, idavomerezedwa ndi European Commission pochiza matenda ena ovuta a pakhungu ndi minofu yofewa omwe amayamba chifukwa cha mabakiteriya a gram-positive.Pa September 6, 2007, Cubist Pharmaceuticals analengeza kuti European Union wavomereza mankhwala ake antibacterial, Cubicin zochizira lamanja endocarditis chifukwa cha matenda Staphylococcus aureus ndi zovuta khungu ndi zofewa matenda matenda okhudzana ndi matenda chifukwa Staphylococcus aureus.