Darunavir CAS 206361-99-1 Anti-HIV Purity ≥99.0% API High Purity HIV Protease Inhibitor

Darunavir (dzina la Prezista, lomwe kale limadziwika kuti TMC114) ndi mankhwala oletsa ma protease omwe amagwiritsidwa ntchito pochiza kachilombo ka HIV.Darunavir ndi njira yochiritsira yomwe OARAC imayamikiridwa kwa akulu ndi achinyamata osadziwa chithandizo komanso odziwa chithandizo.Darunavir ndi mtundu watsopano wa non peptide anti retroviral protease inhibitors mu AIDS therapy.Idapangidwa koyamba ndi nthambi ya Johnson pharmaceutical Iceland, Tibotec.Ndiwopezeka kwambiri wa bioavailability mu 6 protease inhibitors (saquinavir, ritonavirvir, indinavir, naphthalene nelfinavir, amprenavir ndi ABT378/r).Zimagwira ntchito poletsa kupangika kwa tinthu tating'onoting'ono tomwe timatulutsa kachilomboka kuchokera pamwamba pa ma cell omwe ali ndi kachilomboka ndikulepheretsa ma virus a protease.Mankhwalawa akagwiritsidwa ntchito kwa nthawi yayitali, amatha kuchepetsa kachilombo ka HIV m'magazi, kuwonjezera kuchuluka kwa maselo a CD4, kuchepetsa mwayi wotenga kachilombo ka HIV, kukhala ndi moyo wabwino komanso kutalikitsa moyo.Ndi yoyenera kwa akuluakulu omwe ali ndi kachilombo ka HIV koma alibe mphamvu pakugwiritsa ntchito mankhwala omwe alipo kale.The mankhwala ayenera pamodzi ntchito otsika Mlingo wa ritonavir kapena ma ARV, kuti patsogolo lapamwamba.Ntchito yoletsa ma virus mu vitro imatha kuyesedwa polimbana ndi ma lymphocyte omwe ali ndi kachilombo koyambitsa matenda komanso ma lymphocyte m'magazi ozungulira.