Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor
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| Dzina la Chemical | Darunavir Ethanolate |
| Mawu ofanana ndi mawu | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R) -3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR) -hexahydrofuro [2,3-b]furan-3-yl ester compd.ndi ethanol |
| Nambala ya CAS | 635728-49-3 |
| Nambala ya CAT | RF-API69 |
| Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
| Molecular Formula | Chithunzi cha C29H43N3O8S |
| Kulemera kwa Maselo | 593.73 |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera kapena Woyera wa Crystalline |
| Chizindikiro cha IR | Zimagwirizana ndi Standard Spectrum |
| Kuzungulira Kwapadera | -0.5°~ +0.5° |
| Zogwirizana nazo | (Wolemba HPLC) |
| Max Kusayera Kumodzi | ≤0.20% |
| Zonse Zonyansa | ≤0.50% |
| Madzi (KF) | ≤1.0% |
| Zotsalira pa Ignition | ≤0.10% |
| Zitsulo Zolemera | ≤10ppm |
| Zomwe zili mu Ethanol | ≤7.5% (GC) |
| Zosungunulira Zotsalira | Methanol ≤0.30% |
| Chiyero | ≥99.0% (HPLC) |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni Drum, 25kg/ng'oma, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Darunavir Ethanolate (Prezista) ndi HIV protease inhibitor.Kuchokera ku Darunavir, m'badwo wachiwiri wa HIV-1-protease inhibitor;zofananira ndi amprenavir.Antivayirasi.Ndi kafukufuku wokhudzana ndi COVID19.Tsoka ilo, DRV imakhala ndi kusungunuka kochepa m'madzi komanso kusapezeka bwino kwa bioavailability, chifukwa chake pamafunika kuwongolera m'miyeso yayikulu kwambiri kuti iwonetse mphamvu zakuchiritsa.Darunavir ndi chopinga chachikulu chomwe chimagwira ntchito polimbana ndi kachilombo ka HIV-1 komwe kamakhala ndi cytotoxicity yochepa.Darunavir imapanga zomangira za haidrojeni ndi maatomu akuluakulu osungidwa a Asp29 ndi Asp30 a protease.Kuyanjana uku kukuyembekezeka kukhala kofunikira kwambiri pa mphamvu ya mankhwalawa polimbana ndi kachilombo ka HIV komwe kamalimbana ndi ma protease inhibitors angapo.Mu kafukufuku wa in vitro m'maselo a MT-2, mphamvu ya darunavir ndi yayikulu kuposa ya saquinavir, amprenavir, nelfinavir, indinavir, lopinavir ndi ritonavir.Darunavir imapangidwa makamaka ndi ma enzymes a hepatic cytochrome P450 (CYP), makamaka CYP3A.Mlingo wa 'boosting' wa ritonavir umakhala wolepheretsa CYP3A, motero umakulitsa kupezeka kwa darunavir bioavailability.Darunavir idapangidwa kuti ipange kuyanjana kolimba ndi puloteni ya protease kuchokera ku mitundu yambiri ya HIV, kuphatikiza zovuta zochokera kwa odwala omwe ali ndi chithandizo chamankhwala omwe ali ndi multiple resistance mutati.
