Desmopressin Acetate CAS 16789-98-3 Peptide Purity (HPLC) ≥98.5% Factory

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Desmopressin Acetate (CAS: 16789-98-3) ndiko kuti, 1-cysteine ​​deamination ndi 8-D-arginine m'malo mwa 8-l-arginine, yomwe imadziwikanso kuti arginine vasopressin, ndi analog yachilengedwe ya arginine vasopressin, yochokera ku vasopressin, mphamvu yake ya antidiuretic imakhala yamphamvu komanso yokhalitsa kuposa vasopressin, koma palibe vasoconstrictor, zotsatira zoyipa za mankhwala, matenda obadwa nawo kapena opangidwa ndi mankhwala osokoneza bongo, uremia, cirrhosis yachiwindi ndi zifukwa zosadziwika zomwe zimayambitsidwa ndi nthawi yayitali ya magazi;Itha kugwiritsidwa ntchito poletsa ndikuletsa kutuluka kwa magazi panthawi ya opaleshoni yaying'ono;Central Diabetes insipidus.Muzochitika payekha, mankhwalawa amatha kutulutsa mphamvu kwa odwala omwe ali ndi matenda amkodzo, omwe nthawi zambiri amapunduka kwa odwala omwe ali ndi matenda a Type IIB von Willebrand.
Pharmacological action: Desmopressin Acetate ili ndi desmopressin yomwe imafanana ndi arginine vasopressin.Ndiko kusiyana pakati pa arginine vasopressin, makamaka theka la amino acid ndi D arginine m'malo mwa L Arginine.Zosintha zamapangidwe izi zimatalikitsa nthawi yogwira ntchito yachipatala cha desmopressin popanda zotsatira za kupsinjika.Kafukufuku wina wasonyeza kuti zotsatira za anti-enuresis ndizofunikira, zomwe zingakhale chifukwa cha kuwonjezeka kwa arginine vasopressin m'magazi a ana usiku, ndiyeno amaika mkodzo, kuchepetsa kuchuluka kwa mkodzo ndi kuthamanga kwa intravascular, kuchepa kwa khosi, kuchepa kwa detrusor.
Kuchita bwino kwake, kumasuka kwa kayendetsedwe kake (intranasal), nthawi yayitali yochitapo kanthu, komanso kusowa kwa zotsatira zake kumapangitsa kuti ikhale mankhwala osankhidwa pochiza matenda apakati a shuga insipidus.Itha kuperekedwanso intramuscularly ortravenously.Amakonda jekeseni wa vasopressin ndi oral antidiuretics kuti agwiritse ntchito ana.Zimasonyezedwa ndi kasamalidwe ka temporary polydipsia ndi polyuria yokhudzana ndi kuvulala, kapena opaleshoni m'dera la pituitary.
Kugwiritsa Ntchito Zachipatala: Desmopressin, monga mchere wa acetate, ndi analogue yopangidwa ndi vasopressin momwe N terminal Cys ilibe α-amino ntchito (1-Deamino) komanso komwe Arg8 ilipo ngati D-isomer (D-Arg8) , motero dzina lamalonda la DDAVP.Kukhalapo kwa D-Arg komanso kusakhalapo kwa N-terminal amine mu kapangidwe ka desmopressin kwawonjezera theka la moyo wake kotero kuti imapezeka kuti igwiritsidwe ntchito pakamwa, pobereka, kapena m'mphuno.Amagwiritsidwa ntchito ndi njira zonse zitatuzi zothandizira kupewa kapena kuwongolera polydipsia (ludzu lambiri), polyuria, komanso kutaya madzi m'thupi kwa odwala omwe ali ndi matenda a shuga insipidus chifukwa cha kusowa kwa vasopressin.Zavomerezedwanso kuti azichiza nocturnal enuresis (kunyowetsa pabedi), zomwe amakhulupirira kuti zimayamba chifukwa cha kusakwera kwanthawi yausiku kwa milingo ya vasopressin.Desmopressin imadziwika kuti imayambitsa kuwonjezeka kwa plasma factor VIII (antihemophilic factor) ndi plasminogen activator.Chifukwa chake amavomerezedwa ndi US FDA kuti agwiritsidwe ntchito, mwaubereki komanso m'mphuno, pochepetsa kukhetsa magazi modzidzimutsa kapena kupwetekedwa mtima kwa odwala omwe ali ndi hemophilia A ndi matenda amtundu I Von Willebrand, malinga ngati ntchito yawo ya plasma factor VIII ndi yayikulu kuposa 5%.Kuyerekeza, utsi wa m'mphuno ntchito pochiza odwala hemophilia A ndi mtundu I Von Willebrand matenda, ndi 15 pindani ndende ya DDAVP utsi wa m'mphuno;yotsirizirayi imagwiritsidwa ntchito pochiza matenda a shuga insipidus.