Diethylphosphonoacetic Acid CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory

Kufotokozera Kwachidule:

Dzina la Mankhwala: Diethylphosphonoacetic Acid

CAS: 3095-95-2

Kuyera:> 99.5% (HPLC)

Maonekedwe: Madzi Opanda Mtundu

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Ubwino Wapamwamba, Kupanga Zamalonda

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	Diethylphosphonoacetic Acid
Mawu ofanana ndi mawu	2-(Diethoxyphosphoryl)acetic Acid;(Diethoxyphosphinyl)acetic Acid;Diethyl Carboxymethylphosphonate;Chithunzi cha NSC 272281
Nambala ya CAS	3095-95-2
Nambala ya CAT	RF-PI2024
Stock Status	Mu Stock, Kupanga Mphamvu 30MT/Mwezi
Molecular Formula	(C2H5O)2P(O)CH2CO2H
Kulemera kwa Maselo	196.14
Boiling Point	150 ℃/0.05 mmHg (lit.)
Kuchulukana	1.220 g/mL pa 25 ℃ (lit.)
Refractive Index	n20/D 1.445 (lit.)
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Mtundu Wamadzimadzi
Chizindikiritso (HPLC)	Nthawi yosungira pachimake chachikulu chopezedwa kuchokera pachitsanzo chili mkati mwa 5% yachitsanzo chofotokozera.
Kuyera / Kusanthula Njira	> 99.5% (HPLC)
Infrared Spectrum	Zimagwirizana ndi Kapangidwe
Proton NMR Spectrum	Zimagwirizana ndi Kapangidwe
Chinyezi (KF)	<0.50%
Zonse Zonyansa	<0.50%
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Phukusi & Kusungira:

Phukusi: Botolo la Fluorinated, 25kg / Drum, kapena malinga ndi zomwe kasitomala amafuna

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi

Ubwino:

FAQ:

Ntchito:

Diethylphosphonoacetic Acid (CAS: 3095-95-2), Amagwira ntchito ngati nucleophile ya nucleophilic yowonjezerapo kuti apange kaphatikizidwe ka allene epoxides Reactant for: Stereoselectivity studies of the Staudinger reaction;Enantioselective mapangidwe diols kudzera epoxidation ndi hydration zimachitikira;Horner-Wadsworth-Emmons zochita;Remote chelation controlled Ireland-Claisen rearrangement;Ugi-Dieckmann zochita za kaphatikizidwe wa tetramic acid zotumphukira;Amagwiritsidwa ntchito kupanga phosphonoester intermediates kwa intramolecular HEW reactions.Diethylphosphonoacetic Acid ndi wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7).Afatinib Dimaleate adavomerezedwa ndi US Food and Drug Administration (FDA) mu 2013 kuti azichiza khansa ya m'mapapo yopanda maselo ang'onoang'ono (NSCLC).Makamaka, idavomerezedwa kwa odwala omwe ali ndi zotupa za metastatic NSCLC zomwe zimakhala ndi epidermal growth factor receptor (EGFR) exon deletions kapena exon 21 masinthidwe.Afatinib Dimaleate ndi covalent inhibitor ya ErbB tyrosine kinases (tyk), yomwe imachepetsa kusaina kwa ErbB mwa kumangirira kosasinthika kwa malo omangira a EGFR tyk.