Diflorasone Diacetate CAS 33564-31-7 Assay 97.0~103.0% Factory Corticosteroid

Diflorasone Diacetate [33564-31-7]
» Diflorasone Diacetate ili ndi osachepera 97.0 peresenti komanso osapitirira 103.0 peresenti ya C26H32F2O7, yowerengedwa pa zouma.
Kupaka ndi kusunga-Sungani zotengera zothina.
Miyezo yolozera ya USP <11>-
USP Diflorasone Diacetate RS
Chizindikiritso, Mayamwidwe a Infrared <197M>.
Kusinthasintha kwachindunji <781S>: pakati pa +58° ndi +68°.Njira yothetsera mayeso: 20 mg, osauma, pa ml, mu chloroform.
Kutaya pa kuyanika <731> -Kuumitsa mu vakuyumu pa 60 ° ndi pa kuthamanga osapitirira 5 mm mer cury kwa maola 16: amataya osapitirira 0,5% ya kulemera kwake.
Zotsalira pakuyatsa <281>: osapitirira 0.5%
Chromatographic chiyero -
Mobile phase ndi Chromatographic system-Konzekerani monga mwauzira mu Assay.
Sungunulani muyeso woyezedwa bwino wa Diflorasone Diacetate mu chloroform yodzaza ndi madzi kuti mupeze yankho lomwe lili ndi kuchuluka kwa pafupifupi 6 mg pa mL.
Kachitidwe-Bayikirani voliyumu (pafupifupi 10 µL) ya njira Yoyesera mu chromatograph, lembani chromatogram kwa nthawi yofanana ndi nthawi 5 ya nthawi yosungira pachinsonga chachikulu, ndikuyesa madera ansonga zonse.Werezerani kuchuluka kwa zodetsa zilizonse mu gawo la Diflorasone Diacetate lomwe latengedwa ndi formula:
100 (ri / rs)
m'mene ri ndi malo okwera pachidebe chilichonse;ndipo rs ndiye chiŵerengero cha madera a nsonga zonse: osapitirira 1.0% ya zonyansa zilizonse zomwe zimapezeka;ndipo zosaposa 2.0% ya zonyansa zonse zimapezeka.
Kuyesa-
Mobile phase-Konzani yankho lomwe lili ndi madzi osakaniza a n-butyl chloride, methylene chloride yodzaza ndi madzi, glacial acetic acid, ndi tetrahydrofuran (350:125:15:10).Sinthani ngati kuli kofunikira (onani Kuyenerera Kwadongosolo pansi pa Chromatography <621>).
Internal standard solution-Pogwiritsa ntchito chloroform yodzaza ndi madzi, konzani yankho la isoflupredone acetate lomwe lili ndi pafupifupi 0.04 mg pa ml.
Kukonzekera kokhazikika-Sungani muyeso woyezedwa bwino wa USP Diflorasone Diacetate RS mu Internal standard solution kuti mupeze yankho lokhala ndi kuchuluka kodziwika kwa pafupifupi 33µg pa mL.
Kukonzekera kuyesa-Kusamutsa pafupifupi 15 mg ya Diflorasone Diacetate, yoyezedwa molondola, ku botolo la volumetric 500-mL.Onjezani njira yokhazikika yamkati ku voliyumu, ndikusakaniza.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 254-nm ndi ndime ya 4.6-mm × 10-cm yomwe ili ndi 3- µm yonyamula L3.Kuthamanga kwa madzi ndi pafupifupi 2.5 ml pa mphindi.Chromatograph the Standard kukonzekera, ndikujambulitsa madera apamwamba monga momwe adalangizidwira Ndondomeko: chigamulo, R, pakati pa analyte ndi nsonga zamkati zamkati sizochepera 12;ndipo kupatuka kwapang'onopang'ono kwa ma jakisoni osachepera anayi osapitilira 2.0%.
Kachitidwe-Papatula jekeseni ma voliyumu ofanana (pafupifupi 10 µL) a Kukonzekera Kwanthawi zonse ndi kukonzekera kwa Assay mu chromatograph, lembani ma chromatogram, ndikuyesa madera a nsonga zazikulu.Nthawi zosungirako ndi pafupifupi 1.0 ya diflorasone diacetate ndi 2.4 ya muyezo wamkati.Werengetsani kuchuluka, mu mg, wa C 26H32F2O7 mu gawo la Diflorasone Diacetate yotengedwa ndi formula:
0.5C(RU / RS)
momwe C ndi ndende, mu µg pa mL, ya USP Diflorasone Diacetate RS mu kukonzekera kwa Standard;ndi RU ndi RS ndizofanana ndi madera apamwamba kwambiri a Diflorasone Diacetate ndi madera amkati omwe amachokera ku Kukonzekera kwa Assay ndi Kukonzekera kwa Standard, motsatira.