DMF-DMA CAS 4637-24-5 N,N-Dimethylformamide Dimethyl Acetal Purity>99.0% (GC) Factory Hot Sale

Popeza Meenvin adanena za kukonzekera kwa DMF-DMA (N,N-Dimethylformamide Dimethyl Acetal) mu 1956, DMF-DMA yakhala reagent yomwe nthawi zambiri imagwiritsidwa ntchito popanga organic synthesis.
DMF-DMA imagwiritsidwa ntchito kwambiri pomanga mphete zisanu kapena zisanu ndi imodzi zokhala ndi heterocyclic pakutseka kwa mphete.DMF-DMA imakhala ndi machitidwe ochepera komanso zokolola zambiri, makamaka pamagulu otsutsa kwambiri.
Kapangidwe kake ka amide acetal compounds ndi motere:
Zomwe zimagwiritsidwa ntchito kwambiri ndi DMF-DMA ndi DMF-DEA, amide acetal imapangidwa mosavuta ndi hydrolyzed, ikhoza kukhala esterified, amidine, alkylation ndi cyclization reaction.
Atomu yapakati ya kaboni ya DMF-DMA imalumikizidwa ndi ma heteroatomu atatu okhala ndi electronegative yayikulu, yomwe imapangitsa kuti ikhale ndi mphamvu zamagetsi zamagetsi.Pansi pa asidi, gulu la alkoxy ndilosavuta kuchoka, ndipo ma ions abwino omwe ali ndi mphamvu zama electrophilic amapezeka.Zomwe DMF-DMA zimachita makamaka zimakhala ndi methylation reaction and formation reaction.
"One-carbon Syntheson" ya DMF-DMA
Pakutseka kwa loop kukhudzana ndi DMF-DMA, atomu imodzi yokha ya kaboni muzinthuzo nthawi zambiri imaperekedwa ndi DMF-DMA, kotero DMF-DMA imatha kuwonedwa ngati kaphatikizidwe ka kaboni.
DMF-DMA esterification reaction
DMF-DMA esterification imathandizira ma carboxylic acid osiyanasiyana kupanga C1-20 alkili kapena aryl esters, ndipo zotulutsa zimatha kupatulidwa mosavuta ndi distillation.
Adipic acid ndi DMF-DMA adayikidwa pa madigiri 80 kwa maola awiri.Amide acetal ndi njira yabwino yopangira esterification ya ma carboxylic acid okhala ndi chotchinga cha steric kapena kusakhazikika bwino.
Kuchita kwa DMF-DMA amidination ndi chitetezo cha amines oyambirira
Amide acetals amatha kuchitapo kanthu osati ndi amines oyambirira, komanso ndi amides, carbamates, sulfonamides kupanga ma hydrocarbon bonds.
Monga: 2, 4-dimethyl aniline ndi DMF-DMA pa madigiri 80 akhoza kuchotsa methanol mwamsanga kupanga dimethamidine mankhwala.
DMF-DMA itha kugwiritsidwanso ntchito ngati gulu loyamba la chitetezo cha amine, gulu loyamba la chitetezo cha amine (2 NH chitetezo chonse) mwina anthu ambiri amaganiza za phthalyl, pyrrole ring, double Boc, double PMB, etc., koma DMF-DMA chitetezo cha pulayimale. amine, nthawi zina ndiwothandiza kwambiri chitetezo, chitetezo chimangofunika TFA kusakaniza.
Chitetezo cha Amino - 13 zoyambira zodzitchinjiriza wamba, zokumana nazo pakusankha maziko achitetezo, kugwiritsa ntchito mitundu yosiyanasiyana, zoyambira, kugawana mwachidule
DMF-DMA imakhudzidwa ndi magulu a methyl ndi methylene omwe amagwira ntchito kuti apange ma bond awiri a carbon-carbon
Phenylmethylation ya DMF-DMA
Zotsatira za Heterocyclic mu DMF-DMA
Amide acetal ngati wopereka kaboni m'modzi atha kugwiritsidwa ntchito kupanga zinthu zosiyanasiyana zovuta komanso zachilengedwe za biomimetic.Ndi Amide acetals ikhoza kuphatikizidwa: 1,2.4 Triazolole, 1.2, 4 heinoazocyccycconacc, pyrozine, pyrazone, pyrazine, pyrazine, pyrazine, pyrazine, pyrazine, pyrazine ndi mndandanda wina wa ammonia heterocyclic zotumphukira, angathenso apanga mpweya, sulfure heterocyclic mankhwala.
Malingana ndi mtundu wa mankhwala, kugwiritsa ntchito amide acetal mu heterocyclic compound synthesis akhoza kugawidwa muzinthu zitatu zotsatirazi.
(1): amide acetal ndi amine, amide, carbamate lipid reaction, amapanga mphete zosiyanasiyana za heterocyclic
Amidoacetal ndi amine anachita formamidine wapakatikati, ndiyeno intramolecular nucleophilic mphete anachita kupanga osiyanasiyana heterocycles, kapena formamidine ndi hydrazine, hydroxylamine, L, 2, mmodzi kapena awiri alkyl halides munali magulu awiri yogwira wa mankhwala kuphatikiza unyolo wautali mpweya, ndiyeno intramolecular mphete. .
Kaphatikizidwe wa mankhwala heterocyclic ndi zimene amide acetals ndi amides, monga synthesis L, 2,4 monotriazole zotumphukira.Choyamba, acetal imakhudzidwa ndi amide kupanga N, N 'tritradil, ndiyeno mphete ndi phenylhydrazine kupanga L, 2,4 monotriazole zotumphukira.
Amide acetals amachita ndi carbamic acid kapena acetate kupanga mphete za heterocyclic zokhala ndi klorini.Diactive intermediate yopangidwa ndi momwe amide acetal ndi aminoethyl ester: nn-dimethyl-n 'alkyl-carboxymethyl formamidine, yomwe imakhudzidwa ndi hydrazine kapena hydrazine m'malo.Mwachitsanzo, pokonzekera 1,2,4 triazinone-6, equation ikuwonetsedwa pansipa.Mukachita ndi nitro-formate mumapeza 1,2,4 triazolone-5.
Zomwe zimapangidwira kupanga 1,2,4 triazolone-5
The zikuchokera 1.2.4-triazolidin-5 ndi masitepe awiri.Choyamba, ethyl carbamate ndi DMF diformaldehyde acetals amapanga Nn-dimethyl-n-ethoxy-formamidine wapakatikati.Chachiwiri, gulu la amino pa phenylhydrazine limatsutsa carbon pa formamidine, yomwe imataya -N (CH3).Kenako ammonia pa mphete ya benzene pafupi ndi phenylhydrazine amaukira kaboni pagulu la kaboni, kupanga anion ya oxygen, ndipo ma elekitironi awiri okha pa oxygen amatsika, amataya gulu la ethoxy, ndikupanga 1.2, 4-triazolone-5.
(II) Kukonzekera kwa mankhwala a heterocyclic ndi momwe amide acetal ndi amide
Iyi ndi njira yodziwika kwambiri yodetsa kaphatikizidwe m'zaka makumi angapo zapitazi.Zochita za amide acetal ndizofanana ndi Grignard reagent, koma machitidwe a amide acetal ndi osavuta komanso ofatsa.
Amide acetal ili ndi magulu awiri ogwira ntchito, reactivity yapamwamba, ndi methyl yogwira ntchito, methylene reaction kuti ipange amidine intermediates, ikhoza kukhala yowonjezereka, kutsekedwa kwa mphete, ndi Grignard reagent ndi methylene reaction, kungotalikitsa mpweya wa carbon, sikungakhalenso kuchitapo kanthu.Mwachitsanzo, kaphatikizidwe wa zotumphukira za furanochroone.
(3): amide acetal ndi hydroxyl, sulfhydryl pawiri zochita kupanga mpweya, sulfure heterocyclic mankhwala
Kuphatikizika kwapamwamba kwa furo kuthetsane ndi chitsanzo chabwino cha acetal generation of enamine derivatives and hydroxyl group polekanitsa mlongoti wa endolateral, zomwe zimapangitsa kuti oxy-containing heteramine:.Chitsanzo china: catechol ndi DMF -- DMA imapanga mphete zokhala ndi okosijeni pamaso pa dichloromethane.
Zomwe DMF -- DMA ndi o-mercaptoaniline zimatha kupanga mphete ya sulfure yokhala ndi heterocyclic, mawonekedwe ake ndi awa.
Kafukufuku wochitika wa DMF-DMA ring closure reaction and personal reaction
(1) Batcho-Leimgruber indole kaphatikizidwe
Kukonzekera kwamitundu yosiyanasiyana ya Vindol kuchokera ku o-nitrotoluene.
Reaction limagwirira
Choyamba, dimethylformamide dimethylacetal, ma ions olakwika a gulu la methoxy amachoka kuti apange wapakatikati wokhazikika.Imawukiridwa ndi ma carboanions omwe amapangidwa ndi deprotonation ya o-nitrotoluene methyl hydrogen ndipo amataya methanol kuti apeze enylamine yomwe tatchulayi.Chopangidwa ndi sitepe iyi, enamine, chimafanana ndi alkene yokhala ndi ma elekitironi-kuchotsa ndi ma elekitironi opereka ma electron ophatikizidwa mbali zonse ziwiri (Push-pull olefin ndi polar kwambiri ndipo nthawi zambiri imakhala yofiira chifukwa cha kuchuluka kwakukulu kwa molekyulu. Zomwe zimachitika, gulu la nitro limachepetsedwa kukhala gulu la amino, ndikutsatiridwa ndi cyclization ndikuchotsa kuti mupeze chomaliza.
(2) Zithunzi zamagulu a pyridine zotumphukira
(3) Kaphatikizidwe wa zotumphukira za pyrazole