Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Infection

Kufotokozera Kwachidule:

Dzina la Mankhwala: Entecavir Monohydrate

CAS: 209216-23-9

Maonekedwe: Ufa Woyera Kapena Woyera Wamakristalo

Mankhwala oletsa ma virus omwe amagwiritsidwa ntchito pochiza matenda a Hepatitis B

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Inquiry: alvin@ruifuchem.com

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Kufotokozera:

Zopanga Zopanga Zokhala ndi Chiyero Chapamwamba ndi Ubwino Wokhazikika
Dzina la Mankhwala: Entecavir Monohydrate
CAS: 209216-23-9
Amagwiritsidwa ntchito pochiza matenda a Hepatitis B
API High Quality, Commercial Production

Chemical Properties:

Dzina la Chemical	Entecavir Monohydrate
Mawu ofanana ndi mawu	Entecavir Hydrate;9 - [(1S,3R,4S) -4-Hydroxy-3-(hydroxymethyl) -2-methylenecyclopentyl]guanine Monohydrate
Nambala ya CAS	209216-23-9
Nambala ya CAT	RF-API79
Stock Status	Mu Stock, Kupanga Kufikira Mazana a Kilogram
Molecular Formula	C12H17N5O4
Kulemera kwa Maselo	295.3
Melting Point	> 220 ℃
Kuchulukana	1.81
Mkhalidwe Wotumiza	Kutumizidwa Pansi pa Kutentha Kozungulira
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera Kapena Woyera Wamakristalo
Kusungunuka	Zosungunuka Momasuka mu Dimethylformamide, Zosungunuka Pang'ono M'madzi, Ethanol ndi Methanol
Chizindikiro cha IR	Spectrum ya chitsanzo imafanana ndi ya reference standard
Chizindikiro cha HPLC	Nthawi yosungitsa yachiyeso imafanana ndi yanthawi yolozera
Mkati mwa Madzi (wolemba KF)	5.5% ~ 6.5%
Specific Optical Rotation	+24.0° mpaka +30.0° (DMF: MeOH=1:1 C=1%) (pa zinthu zopanda madzi)
Zotsalira pa Ignition	≤0.10%
Zogwirizana nazo
Furoentecavir	≤0.10%
Entecavir 1-Epimer	≤0.10%
Entecavir 3-Epimer	≤0.10%
8-Methyoxy Entecavir	≤0.10%
Entecavir 4-Epimer	≤0.10%
8-Hydroxy Entecavir	≤0.10%
4-Dimethylsilyl Entecavir	≤0.10%
Entecavir Related Compound A	≤0.10%
Chidetso Chilichonse Chosadziwika	≤0.10%
Zonse Zonyansa	≤0.30%
Zosungunulira Zotsalira
Methanol	≤600ppm
Dichloromethane	≤300ppm
Ethyl Acetate	≤1000ppm
Tetrahydrofuran	≤720ppm
Toluene	≤890ppm
Benzyl Chloride	≤1000ppm
Benzyl Mowa	≤1000ppm
Malire a Microbial
Total Aerobic Counts	≤100cfu/g
Yisiti ndi Nkhungu	≤10cfu/g
Escherichia Coli	Sitiyenera Kuzindikiridwa
Zitsulo Zolemera	≤10ppm
Kuyesa	98.0% ~ 102.0% (HPLC; pamaziko a anhydrous)
Tinthu Kukula	95% ya particles ayenera kukhala mkati mwa 125um
Test Standard	Enterprise Standard;United States Pharmacopoeia (USP) Standard
Kugwiritsa ntchito	Mankhwala oletsa ma virus omwe amagwiritsidwa ntchito pochiza matenda a Hepatitis B

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.

Ubwino:

FAQ:

Ntchito:

Entecavir Monohydrate (CAS 209216-23-9) ndi mankhwala oletsa tizilombo toyambitsa matenda omwe amagwiritsidwa ntchito pochiza matenda a Hepatitis B Virus (HBV).Entecavir Monohydrate ndi nucleoside analog (makamaka, analogue ya guanine) yomwe imalepheretsa reverse transcript, DNA replication and transcript mu vira.Ndi mtundu watsopano wa mankhwala a cyclopentyl acyl guanosine anti-Hepatitis B omwe ali ndi zotsatira za pharmacological zofanana ndi Entecavir.Amagwiritsidwa ntchito pochiza wamkulu Matenda a chiwindi B mmene pali yogwira tizilombo kugawanika, kuchuluka seramu transaminase ALT kapena yogwira zotupa anasonyeza chiwindi histology.Entecavir Monohydrate ndi choletsa champhamvu komanso chosankha cha HBV, chokhala ndi EC50 ya 3.75 nM mu cell ya HepG2.Entecavir ndi reverse transcriptase inhibitor.Imalepheretsa Kachilombo ka matenda a Hepatitis B (HBV) kuti isachuluke komanso kumachepetsa kuchuluka kwa kachilomboka m'thupi.