Flurbiprofen CAS 5104-49-4 Assay 99.0~100.5% (HPLC) Factory

Flurbiprofen
C15H13FO2 244.27
(±) -2-(2-Fluoro-4-biphenylyl) propionic acid [5104-49-4].
Flurbiprofen ili ndi osachepera 99,0 peresenti ndipo osapitirira 100.5 peresenti ya C15H13FO2, yowerengedwa pa zouma.
Kupaka ndi kusungirako- Sungani muzotengera zothina.
Miyezo yolozera ya USP <11>-
USP Flurbiprofen RS
USP Flurbiprofen Related Compound A RS
2-(4-Biphenylyl) propionic acid.
C15H14O2 226.28
Chizindikiritso-
A: Infrared mayamwidwe <197K>.
B: Mayamwidwe a Ultraviolet 197U-
Yankho: 10 µg pa mL.
Chapakatikati: 0.1 N sodium hydroxide.
Kuchuluka kwa Absorbance pa 247 nm ndi pafupifupi 0.8.
Kusungunuka <741>: pakati pa 114 ndi 117.
Kutaya pakuyanika <731> -Iwunitsani mu vacuum pa 60 mpaka kulemera kosalekeza: imataya osapitirira 0,5% ya kulemera kwake.
Zotsalira pakuyatsa <281>: osapitirira 0.1%.
Zitsulo zolemera, Njira II <231>: 0.001%.
Zogwirizana nazo-
Diluent-Konzani madzi osakaniza ndi acetonitrile (11: 9).
Mobile phase-Konzani madzi osefedwa ndi degassed osakaniza, acetonitrile, ndi glacial acetic acid (12:7:1).Sinthani ngati kuli kofunikira (onani Kuyenerera Kwadongosolo pansi pa Chromatography <621>).
Standard stock solution- Sungunulani muyeso woyezedwa bwino waUSP Flurbiprofen Related Compound A RS mu Diluent kuti mupeze yankho lomwe lili ndi kuchuluka kwa pafupifupi 50 µg pa mL.
Njira yothetsera kuyenerera kwa dongosolo-Pipet 2.0 mL ya Standard stock solution mu botolo la volumetric 10-mL, onjezerani pafupifupi 20 mg ya USP Flurbiprofen RS, sungunulani ndi Diluent mpaka voliyumu, ndi kusakaniza.
Yankho lokhazikika-Kusamutsa 2.0 mL ya Standard stock solution ku botolo la volumetric 10.0-mL, sungunulani ndi Diluent mpaka voliyumu, ndikusakaniza.
Njira yothetsera mayeso-Konzani yankho la Flurbiprofen mu Diluent lomwe lili ndi 2.0 mg pa mL.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 254-nm ndi ndime ya 3.9-mm × 15-cm yomwe ili ndi 4-µm yonyamula L1.Kuthamanga kwa madzi ndi pafupifupi 1 ml pa mphindi.Chromatograph the System kuyenerera yankho, ndi kulemba mayankho pachimake monga momwe anayankhira Ndondomeko: nthawi yosungirako ndi pafupi 0.9 kwa Flurbiprofen yokhudzana ndi chigawo A ndi 1.0 ya flurbiprofen;ndipo kupatuka kwapang'onopang'ono kwa jakisoni wobwereza sikudutsa 1.0%.
Kachitidwe-Mosiyanirana jekeseni ma voliyumu ofanana (pafupifupi 20 µL) a njira Yoyezera ndi Njira Yoyesera mu chromatograph, lembani ma chromatogram, ndikuyesa madera a nsonga zazikulu.Werengani kuchuluka kwa flurbiprofen yokhudzana ndi gulu A mu gawo la Flurbiprofen lomwe limatengedwa ndi chilinganizo:
100(CS / CU)(rU / rS)
momwe CS ndi ndende, mu µg pa mL, ya USP Flurbiprofen Related Compound A RS mu Standard solution;CU ndiye ndende, mu µg pa mL, ya Flurbiprofen mu njira yoyesera;ndi rU ndi rS ndiwo mayankho apamwamba a flurbiprofen okhudzana ndi mankhwala A omwe amapezeka ku Test solution ndi Standard solution, motsatira: osapitirira 0.5% ya flurbiprofen yokhudzana ndi mankhwala A amapezeka.Werengani kuchuluka kwa zodetsa zilizonse mu gawo la Flurbiprofen lomwe latengedwa ndi formula:
100 (ri / rs)
momwe ri ndi yankho lapamwamba pa zonyansa zilizonse zomwe zimapezedwa kuchokera ku Mayeso;ndipo rs ndi chiŵerengero cha mayankho a nsonga zonse zomwe zapezedwa kuchokera ku Mayeso: kuchuluka kwa zonyansa zonse sikuposa 1.0%.
Assay-Sungani pafupifupi 0.5 g wa Flurbiprofen, wolemera bwino, mu 100 ml ya mowa, womwe udasinthidwa kale ndi 0.1 N sodium hydroxide VS mpaka kumapeto kwa phenolphthalein, onjezerani phenolphthalein TS, ndi titrate ndi 0.1 Nsodium hydroxide VS mawonekedwe oyamba mtundu wa pinki womwe umapitilira kwa masekondi osachepera 30.ML iliyonse ya 0.1 N sodium hydroxide ndi yofanana ndi 24.43 mg ya C15H13FO2.