Fondaparinux Sodium CAS 114870-03-0 API
Perekani ndi Kuyera Kwambiri ndi Ubwino Wokhazikika
Dzina la Chemical: Fondaparinux Sodium
CAS: 114870-03-0
Antithrombotic Anticoagulant, Factor Xa Inhibitor
API High Quality, Commercial Production
Dzina la Chemical | Fondaparinux Sodium |
Nambala ya CAS | 114870-03-0 |
Nambala ya CAT | RF-API84 |
Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
Molecular Formula | C31H43N3O49S8.10Na |
Kulemera kwa Maselo | 1728.08 |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Woyera mpaka Woyera |
Njira Yoyesera / Kusanthula | 95.0% ~ 103.0% (zouma) |
Kusungunuka | Zosungunuka Mwaulere M'madzi, 2.0M Sodium Chloride ndi 0.5M Sodium Hydroxide ndi Insoluble mu Ethanol |
Chizindikiritso cha 13C-NMR | Ma resonances a Fondaparinux Sodium ayenera kuwonedwa pa 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, pp.Kusintha kwa Chemical kwa ma siginowa sikusiyana kuposa ± 0.3ppm ma siginecha ena otalika mosiyanasiyana komanso kusintha kwamankhwala, komwe kumachitika chifukwa cha Fondaparinux Sodium, mwina kuwonedwa pakati pa 58.0 ~ 80.5 ppm ndi 98.7 ~ 104.5ppm. |
Chizindikiro cha HPLC | Nthawi yosungira pachimake chachikulu chachitsanzo chachitsanzo chikufanana ndi yankho lokhazikika |
Chizindikiro cha AAS | Sodium ayenera kukhala ndi khalidwe mayamwidwe pa 330.2nm pansi mtima wa sodium |
pH | 6.0-8.0 |
Sodium (Na) | 11.5% ~ 15.0% (Yowerengedwa pa anhydrous ndi zosungunulira zaulere) |
Sulfate yaulere | ≤0.30% |
Chloride yotsalira | ≤1.00% |
Zogwirizana nazo | |
Chidetso A | ≤0.80% |
Chidetso B | ≤0.60% |
Chidetso chimodzi chokha | ≤0.30% |
Zonse Zonyansa | ≤2.00% |
Zosungunulira Zotsalira | |
Methanol | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
M'madzi (KF) | ≤15.0% |
Mabakiteriya Endotoxins | ≤3.3EU/mg |
Malire a Microbial | Chiwerengero chonse cha Tizilombo ≤100cfu/g |
Test Standard | Enterprise Standard;United States Pharmacopoeia (USP) Standard |
Kugwiritsa ntchito | API, Antithrombotic Anticoagulant, Factor Xa Inhibitor |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
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Fondaparinux Sodium (CAS 114870-03-0) ndiye woyamba mwa gulu latsopano la antithrombotic anticoagulant mankhwala okhudzana ndi ma heparin otsika a molekyulu (LMWH).Fondaparinux sodium ndi factor Xa inhibitor kuti apange malo omangirira kwambiri a anti-coagulant factor antithrombin III (ATIII).Kumanga kwa Fondaparinux sodium pamalowa kumapangitsa kuti ATIII atsekeredwe ndi factor Xa ndi chinthu pafupifupi 300, zomwe zimapangitsa kuti thrombin ikhale yolepheretsa.Imagulitsidwa ndi GlaxoSmithKline.Mtundu wanthawi zonse wopangidwa ndi Alchemia umagulitsidwa ku US ndi Dr. Reddy's Laboratories.Fondaparinux sodium idayambitsidwa koyamba ku US kuti ipewe kutsekeka kwa mitsempha yakuya yomwe ingayambitse kutsekeka kwa m'mapapo pambuyo pa opaleshoni yayikulu ya mafupa.Molekyu yopangidwa kwathunthu ndi kopi ya heparin pentasaccharide motsatizana, chidutswa chachifupi kwambiri chomwe chimatha kuletsa antithrombin lllmediated kuletsa kwa factor Xa potero kulepheretsa kubadwa kwa thrombin popanda antithrombin kanthu.
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