Gefitinib CAS 184475-35-2 Purity>99.5% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. ndi omwe amapanga Gefitinib (CAS: 184475-35-2) ndi apamwamba kwambiri.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Gefitinib ndi zapakati,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Gefitinib |
| Mawu ofanana ndi mawu | Gefitinib Free Base;Iressa;ZD1839;ZD-1839;N-(3-Chloro-4-Fluorophenyl) -7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-Amine;N-(3-Chloro-4-Fluorophenyl) -7-Methoxy-6-[3-(4-Morpholinyl) propoxy] -4-Quinazolinamine |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 184475-35-2 |
| Molecular Formula | C22H24ClFN4O3 |
| Kulemera kwa Maselo | 446.91 g / mol |
| Melting Point | 194.0 mpaka 198.0 ℃ |
| Kuchulukana | 1.322±0.06 g/cm3 |
| Kusungunuka kwamadzi | Zosasungunuka m'madzi |
| Kusungunuka | Zosungunuka mu DMSO |
| Kusungirako Temp. | Kutentha kwa Chipinda |
| Manyamulidwe | Wozungulira |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Woyera mpaka Woyera | Zimagwirizana |
| Kutaya pa Kuyanika | <0.50% | 0.13% |
| Zotsalira pa Ignition | <0.20% | 0.06% |
| Chidetso Chimodzi | <0.10% | 0.09% |
| Zonse Zonyansa | <0.50% | 0.20% |
| Zitsulo Zolemera (Pb) | ≤10ppm | <10ppm |
| Kuyera / Kusanthula Njira | > 99.5% (HPLC) | 99.80% |
| Infrared Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| 1H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo la Fluorinated, thumba la Aluminiyamu zojambulazo, 25kg / Cardboard Drum, kapena malinga ndi zomwe kasitomala amafuna.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndipo sungani m'nyumba yozizira, yowuma komanso yolowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Osagwiritsidwa ntchito mwa anthu.Osagwiritsidwa ntchito pozindikira matenda kapena kuchiza.Kugwiritsa ntchito kafukufuku wa in vitro kokha.
Palibe mwazinthu zomwe zidzaperekedwe kumayiko omwe izi zitha kukhala zosemphana ndi ma patent omwe alipo.Komabe udindo womaliza uli ndi Wogula.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
| Kufotokozera Zachitetezo | 24/25 - Pewani kukhudzana ndi khungu ndi maso. |
| HS kodi | 2934999099 |
Gefitinib (CAS: 184475-35-2) ndi mankhwala apadera odana ndi zotupa omwe amapangidwa ndi AstraZeneca, UK.Ndi mankhwala oyamba omwe amapangidwa ndi maselo ochizira khansa ya m'mapapo yosakhala yaying'ono.Zimagwira ntchito poletsa njira yosinthira ma siginali ya epidermal growth factor receptor tyrosine kinase (EGFR-TK).Epidermal growth factor (EGF) ndi polypeptide yokhala ndi molekyulu ya 6.45 × 103, yomwe imatha kuphatikiza ndi epidermal growth factor receptor (EGFR) pa membrane ya cell yomwe ikufuna kupanga zotsatira zachilengedwe.EGFR ndi cholandilira chamtundu wa tyrosine kinase (TK).Ikamangiriza ku EGF, imatha kulimbikitsa kutsegulira kwa TK mu thupi lolandira, zomwe zimapangitsa kuti autophosphorylation ya zotsalira za receptor tyrosine, kupereka zizindikiro zogawanika mosalekeza kwa maselo, zomwe zimapangitsa kuti maselo azichulukana komanso amasiyana.EGFR ndi yochuluka mu minofu yaumunthu ndipo imawonekera kwambiri mu zotupa zowopsa.Mwa kutsekereza njira yowonetsera EGFR pama cell, gefitinib imalepheretsa kukula kwa chotupa, metastasis ndi angiogenesis, ndipo imatha kuyambitsa apoptosis ya maselo otupa.Mu Ogasiti 2002, gefitinib idagulitsidwa koyamba ku Japan ngati chithandizo choyambirira cha khansa ya m'mapapo yopanda maselo ang'onoang'ono pansi pa dzina lamalonda la Iressa.Mu Meyi 2003, bungwe la US Food and Drug Administration lidavomereza gefitinib ngati njira yachitatu yothandizira odwala omwe ali ndi khansa ya m'mapapo yopanda maselo ang'onoang'ono omwe sanagwiritse ntchito mankhwala oletsa khansa opangidwa ndi platinamu ndi docetaxel chemotherapy.Pakalipano, yavomerezedwa ndi Australia, Japan, Argentina, Singapore ndi South Korea pofuna kuchiza khansa ya m'mapapo yomwe si yaing'ono.Pa February 28, 2005, bungwe la China Food and Drug Administration lidavomereza gefitinib kuti azichiza khansa ya m'mapapo yomwe ili m'dera lanu kapena ya metastatic non-small cell lung cancer (NSCLC) yomwe idalandirapo kale mankhwala amphamvu.Sichikuvomerezedwa kuti chigwiritsidwe ntchito ngati chithandizo choyambirira cha NSCLC yapamwamba.Pa Julayi 1, 2009, European Medicines Agency idavomereza mwalamulo gefitinib kuti ikhale chithandizo chamzere woyamba, mzere wachiwiri ndi wachitatu wa khansa ya m'mapapo yomwe si yaing'ono kwambiri m'dera lanu ndi kusintha kwa majini a EGFR mwa akulu.
