Gemcitabine CAS 95058-81-4 Assay 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiye wopanga wamkulu wa Gemcitabine (CAS: 95058-81-4) wokhala ndipamwamba kwambiri.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Gemcitabine,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Gemcitabine |
| Mawu ofanana ndi mawu | 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1- [3,3-Difluoro-4-Hydroxy-5-(Hydroxymethyl) oxolan-2-yl]pyrimidin-2-imodzi;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2', 2'-Difluoro-2'-deoxycytidine;2', 2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine |
| Stock Status | Mu Stock, Mphamvu Yopanga Matani 5 |
| Nambala ya CAS | 95058-81-4 |
| Zogwirizana ndi CAS | 122111-03-9 |
| Molecular Formula | Chithunzi cha C9H11F2N3O4 |
| Kulemera kwa Maselo | 263.20 g / mol |
| Melting Point | 217.0 mpaka 222.0 ℃ |
| Kuchulukana | 1.84±0.10 g/cm3 |
| Zomverera | Kutentha Kwambiri |
| Kusungunuka kwamadzi | Zosasungunuka m'madzi |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Ufa Woyera Kapena Woyera Wamakristalo, Wopanda fungo | Zimagwirizana |
| Cytosine | ≤0.10% | 0.002% |
| α-Isomer | ≤0.10% | 0.01% |
| Chidetso cha Munthu Payekha | ≤0.10% | 0.03% |
| Zonse Zonyansa | ≤1.00% | 0.10% |
| Madzi ndi Karl Fischer | ≤1.00% | 0.67% |
| Kuzungulira Kwapadera | +68.0°~+74.0° | + 70.5 ° |
| Zitsulo Zolemera | ≤10ppm | <10ppm |
| Zotsalira pa Ignition | ≤0.10% | 0.03% |
| Kuyesa (Wolemba HPLC) | 98.0% ~ 102.0% | 99.9% |
| Infrared Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| 1H NMR Spectrum | Zogwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndipo sungani m'nyumba yozizira, yowuma komanso yolowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Pewani kukhudzana ndi kuwala kwa dzuwa, chinyezi ndi kutentha kwambiri.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Zizindikiro Zowopsa R21 - Zowopsa pokhudzana ndi khungu
R36/38 - Kukwiyitsa maso ndi khungu.
R46 - Zingayambitse kuwonongeka kwa majini
R62 - Chiwopsezo chotheka cha kulephera kubereka
R63 - Kuopsa kotheka kwa mwana wosabadwa
Kufotokozera Zachitetezo S25 - Pewani kukhudzana ndi maso.
S26 - Mukakhudzana ndi maso, muzimutsuka nthawi yomweyo ndi madzi ambiri ndipo funsani malangizo achipatala.
S36/37 - Valani zovala zoteteza ndi magolovesi oyenera.
S53 - Pewani kuwonekera - pezani malangizo apadera musanagwiritse ntchito.
HS kodi 2934999091
Poizoni LD10 iv mu makoswe: 200 mg/m2 (Abbruzzese)
Gemcitabine (CAS: 95058-81-4) ndi mankhwala a chemotherapy omwe amagwiritsidwa ntchito pochiza mitundu ingapo ya khansa.Izi zikuphatikizapo khansa ya m'mawere, khansara ya m'mapapo yosakhala yaing'ono, khansa ya m'mapapo, khansa ya m'chikhodzodzo, ndi khansa ya biliary tract.Gemcitabine ikufufuzidwa kuti igwiritsidwe ntchito pa khansa ya esophageal, ndipo imagwiritsidwa ntchito moyesera mu lymphomas ndi mitundu ina ya chotupa.Gemcitabine imayendetsedwa ndi njira yodutsa mtsempha, chifukwa imapangidwa kwambiri ndi m'mimba.
Gemcitabine ndi analogue ya nucleotide, yomwe ili m'gulu la anti-metabolic lamankhwala oletsa khansa.Imagwira makamaka pa DNA synthesis phase, ndiye kuti, S gawo.Pazifukwa zina, imatha kuletsa gawo la G1 kupita ku S gawo.Ili ndi mawonekedwe amitundu yonse ya anticancer, njira yapadera yochitirapo kanthu, kawopsedwe kakang'ono, palibe kutsutsana ndi mankhwala ena a chemotherapy komanso palibe superposition ya kawopsedwe.Chemicalbook, gemcitabine, tsopano yavomerezedwa kuti igwiritsidwe ntchito m'maiko opitilira 90, ndikupangitsa kuti ikhale njira yoyamba yothandizira khansa ya m'mapapo yopanda maselo ang'onoang'ono komanso "muyezo wagolide" wa khansa ya kapamba.
Mu 1999, CFDA anavomereza gemcitabine zochizira m'deralo zapamwamba kapena metastatic NSCLC, kwanuko patsogolo kapena metastatic kapamba khansa;Mu 2010, CChemicalbookFDA idavomereza gemcitabine kuphatikiza paclitaxel pochiza khansa ya m'mawere yosasinthika, yanthawi zonse kapena ya metastatic yomwe idayambiranso pambuyo pa adjuvant/neoadjuvant chemotherapy.
Gemcitabine ndi yotakata sipekitiramu antimetabolite ndi deoxycytidine analogue ndi antineoplastic ntchito.Akamayendetsedwa, gemcitabine imasinthidwa kukhala metabolites yogwira difluorodeoxycytidine diphosphate (dFdCDP) ndi difluorodeoxycytidine triphosphate (dFdCTP) ndi deoxycytidine kinase.dFdCTP imapikisana ndi deoxycytidine triphosphate (dCTP) ndipo imaphatikizidwa mu DNA.Izi zimatseka DNA polymerase potero kumabweretsa kuthetsedwa kobisika panthawi ya kubwereza kwa DNA.Kumbali ina, dFdCDP imaletsa ribonucleotide reductase, motero kumachepetsa dziwe la deoxynucleotide lopezeka kuti DNA synthesis.Kuchepa kwa ndende ya intracellular ya dCTP kumapangitsa kuti dFdCTP ikhale mu DNA.
