Glycine CAS 56-40-6 (H-Gly-OH) Mayeso 98.5 ~ 101.5% Factory High Quality

Chithunzi cha USP35-NF30
TANTHAUZO
Glycine ili ndi NLT 98.5% ndi NMT 101.5% ya glycine (C2H5NO2), yowerengedwa pa maziko owuma.
CHIZINDIKIRO
A. KUYAMBIRA KWA INFRARED <197M>
ZOYESA
• NTCHITO
Chitsanzo: 150 mg ya Glycine
Chopanda kanthu: 100 ml ya glacial acetic acid
Titrimetric system
(Onani Titrimetry <541>.)
Mode: Direct titration
Titrant: 0.1 N pa chloric acid VS
Kuzindikira komaliza: Zowoneka
Kuwunika: Sungunulani Chitsanzo mu 100 ml ya glacial acetic acid, ndi kuwonjezera dontho limodzi la crystal violet TS.Titrate ndi Titrant mpaka kumapeto kobiriwira.Chitani kutsimikiza kopanda kanthu.
Werengani kuchuluka kwa glycine (C2H5NO2) mu Zitsanzo zomwe zatengedwa:
Zotsatira = {[(VS − VB) × N × F]/W} × 100
VS = Voliyumu ya Titrant yomwe imadyedwa ndi Zitsanzo (mL)
VB = Voliyumu ya Titrant yomwe imadyedwa ndi Chopanda kanthu (mL)
N = chikhalidwe chenicheni cha Titrant (mEq/mL)
F = chinthu chofanana, 75.07 mg/mEq
W = kulemera kwachitsanzo (mg)
Njira zolandirira: 98.5% -101.5% pazowuma
ZOCHITSA
• ZOSALA PA ZOYAMBITSA <281>: NMT 0.1%
• CHLORIDE NDI SULFATE, Chloride <221>
Njira yothetsera: 0,10 mL ya 0.020 N hydrochloric acid
Chitsanzo: 1 g ya Glycine
Njira zolandirira: NMT 0.007%
• CHLORIDE NDI SULFATE, Sulfate <221>
Njira yothetsera: 0,20 mL ya 0.020 N sulfuric acid
Chitsanzo: 3 g ya Glycine
Njira zolandirira: NMT 0.0065%
• ZINTHU ZOWERA, Njira I <231>: NMT 20 ppm
• ZINTHU ZOWERA, Njira I <231>: NMT 20 ppm
Yankho lachitsanzo: 100 mg/mL ya Glycine
Kuwunika: Wiritsani 10 mL ya Zitsanzo za yankho kwa mphindi imodzi, ndikuyika pambali kwa 2 h.
Njira zovomerezeka: Yankho likuwoneka lomveka bwino komanso losavuta ngati 10 mL ya yankho lomwelo lomwe silinaphike.
MAYESO AKE
• KUTAYEKA PA KUYANTHA <731>: Yanikani chitsanzo pa 105° kwa 2 h: imataya NMT 0.2% ya kulemera kwake.
ZOWONJEZERA ZOFUNIKA
• KUPAKA NDI KAKHALIDWE: Sungani m’zotengera zotsekedwa bwino.
• MFUNDO ZA USP REFERENCE <11>
USP Glycine RS

Japan Pharmacopoeia JP17
Glycine, ikauma, imakhala yosachepera 98.5% ya Glycine(C2H5NO2).
Kufotokozera Glycine amapezeka ngati woyera, makhiristo kapena ufa wacrystalline.Ili ndi kukoma kokoma.Imasungunuka mosavuta m'madzi ndi mu formic acid, ndipo imakhala yosasungunuka mu ethanol (95).Imawonetsa crystal polymorphism.
Chizindikiritso Dziwani kuchuluka kwa mayamwidwe a infrared a Glycine, owumitsidwa kale, monga momwe adayankhidwira mu njira ya potassiumbromide disk pansi pa Infrared Spectrophotometry <2.25>, ndipo yerekezerani sipekitiramu ndi Reference Spec-trum: mawonekedwe onsewa amawonetsa kulimba kofanana kwa mayamwidwe pa manambala ofanana.Ngati pali kusiyana kulikonse pakati pa mawonekedwe, sungunulani Glycine m'madzi, sinthani kuyanika kwamadzi, ndikubwereza mayesowo ndi zotsalira.
pH <2.54> Sungunulani 1.0 g ya Glycine mu 20 ml ya madzi: thepH ya yankho ili pakati pa 5.6 ndi 6.6.
Chiyero
(1) Kumveka bwino ndi mtundu wa yankho-Sungani 1.0 gof Glycine mu 10 ml ya madzi: yankho ndilomveka komanso lopanda mtundu.
(2) Chloride <1.03>-Yesani mayeso ndi 0.5 g ya Glycine.Konzani njira yowongolera ndi 0.30 mL ya 0.01mol/L hydrochloric acid VS (osapitirira 0.021%)
(3) Sulfate <1.14>-Yesani mayeso ndi 0,6 g ya Glycine.Konzani njira yowongolera ndi 0.35 mL ya 0.005mol/L sulfuric acid VS (osapitirira 0.028z).
(4) Ammonium <1.02>-Yesani mayeso pogwiritsa ntchito 0,25 g ya Glycine.Konzani njira yowongolera ndi 5.0 mL ya Standard Ammonium Solution (osapitirira 0.02%).
(5) Zitsulo Zolemera <1.07>-Pitirizani ndi 1.0 g ya Glycine molingana ndi Njira 1, ndikuyesani.Konzani njira yowongolera ndi 2.0 mL ya Standard Lead Solution (osapitirira 20 ppm).
(6) Arsenic <1.11> -Konzani yankho loyesa ndi 1.0 gof Glycine molingana ndi Njira 1, ndikuchita mayeso (osapitirira 2 ppm).
(7) Zinthu Zogwirizana-Sungani 0,10 g ya Glycine mu 25mL yamadzi ndikugwiritsa ntchito yankholi ngati njira yothetsera.Chitoliro cha 1 ml ya yankho lachitsanzo, onjezerani madzi kuti mupange 50 ml ndendende.Chitoliro cha 5 mL cha yankho ili, onjezerani madzi kuti mupange 20 mL, ndipo gwiritsani ntchito yankholi ngati yankho lokhazikika.Yesani mayeserowa ndi mayankhowa monga momwe akufunira pansi pa Thin-layer Chromatography<2.03>.Malo 5mL iliyonse ya yankho lachitsanzo ndi yankho lokhazikika pa mbale ya silika gelisi forthin-wosanjikiza chromatography.Pangani mbaleyo ndi chisakanizo cha 1-butanol, madzi ndi acetic acid (100) (3:1:1) mpaka mtunda wa 10 cm, ndikuwumitsa mbaleyo pa 80 ℃ kwa mphindi 30.Utsi wofanana yankho la ninhydrin mu acetone (1 mu 50), ndi kutentha pa 80 ℃ kwa mphindi 5: madontho ena kupatulapo malo ofunikira kuchokera ku yankho lachitsanzo sali olimba kuposa malo omwe amachokera mu njira yokhazikika.
Kutaya pa Kuyanika <2.41> Osapitirira 0.30% (1 g, 105 ℃, maola 3).
Zotsalira pakuyatsa <2.44> Osapitirira 0.10% (1g).
Kuyeza Kuyeza molondola za 80 mg ya Glycine, yowumitsidwa kale, sungunuka mu 3 mL ya formic acid, onjezerani 50 mL ya acetic acid (100), ndi titrate <2.50> ndi 0.1 mol/L perchloric acid VS (potentiometric titration).Chitani chitsimikiziro chopanda kanthu, ndikuwongolera koyenera.
ML iliyonse ya 0.1 mol/L perchloric acid VS＝7.507 mg ya C2H5NO2
Zotengera ndi zosungiramo Zotengera-zotsekedwa bwino.