N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Intermediate High Purity
Zogulitsa Zamalonda Imatinib Mesylate ndi Othandizira Ogwirizana:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4 - [(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS: 106261-49-8
Dzina la Chemical | N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine |
Mawu ofanana ndi mawu | Imatinib Mesylate Pakati;2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pyrimidine |
Nambala ya CAS | 152460-09-8 |
Nambala ya CAT | RF-PI228 |
Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
Molecular Formula | C16H13N5O2 |
Kulemera kwa Maselo | 307.31 |
Melting Point | 188.0 ~ 193.0 ℃ |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Wachikasu Kapena Wapafupi Wachikasu |
Chiyero | ≥98.0% (HPLC) |
Chinyezi (KF) | ≤0.50% |
Zonse Zonyansa | ≤2.0% |
Kusayera Kwambiri Kumodzi | ≤1.0% |
Zotsalira pakuyatsa | ≤0.50% |
Zitsulo Zolemera | ≤20ppm |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | Pakati pa Imatinib Mesylate (CAS: 220127-57-1) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
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Shanghai Ruifu Chemical Co., Ltd. ndiwopanga komanso ogulitsa N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine (CAS: 152460-09-8) ndi apamwamba.Ndiwopakatikati mwa kaphatikizidwe ka Imatinib Mesylate (CAS: 220127-57-1).
Imatinib Mesylate ndi kamolekyu kakang'ono kamene kamalepheretsa c-Abl protein-tyrosine kinase, Kwambiri makamaka kwa BCR-ABL, puloteni yokhudzana ndi matenda a myelogenous leukemia (CML) ndi mitundu ina ya acute lymphoblastic leukemia (ALL).Chochitika chosinthira pakati pa ma chromosome 9 ndi 22 chimapanga chromosome ya Philadelphia, yomwe imatulutsa puloteni ya Bcr-Abl fusion yokhala ndi ntchito ya aberrant kinase yomwe imalimbikitsa kuchuluka kwa maselo mwachangu.Imatinib Mesylate imamanga kinase yofunikayi, kuyimitsa kukula kokhudzana ndi CML.Imatinib Mesylate yawonetsedwanso kuti inhibit PDGFR ndi tyrosine kinases yokhudzana ndi c-Kit.Mapangidwe okhala ndi Imatinib Mesylate akhala akugwiritsidwa ntchito pochiza makhansa osiyanasiyana.