N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Zogulitsa Zamalonda Imatinib Mesylate ndi Othandizira Ogwirizana:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4 - [(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Dzina la Chemical | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Mawu ofanana ndi mawu | Imatinib Mesylate Pakati;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pyrimidine |
| Nambala ya CAS | 152460-10-1 |
| Nambala ya CAT | RF-PI230 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C16H15N5 |
| Kulemera kwa Maselo | 277.32 |
| Melting Point | 133.0-135.0 ℃ |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Wowala Walanje kupita ku Ufa Wachikasu kupita ku Crystal |
| Kuyera / Kusanthula Njira | ≥98.0% |
| Kutaya pa Kuyanika | ≤0.50% |
| Zotsalira pakuyatsa | ≤0.50% |
| Zonse Zonyansa | ≤2.0% |
| Kusayera Kwambiri Kumodzi | ≤1.0% |
| Zitsulo Zolemera | ≤20ppm |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Pakati pa Imatinib Mesylate (CAS: 220127-57-1) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani m'mitsuko yosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Shanghai Ruifu Chemical Co., Ltd. ndiwopanga komanso ogulitsa N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) yokhala ndi mawonekedwe apamwamba. .
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) ndi yapakatikati mwa kaphatikizidwe ka Imatinib Mesylate (CAS: 220127-57-1) API.
Imatinib mesylate ndi kamolekyu kakang'ono kamene kamalepheretsa c-Abl protein-tyrosine kinase, kinase yofunika kwambiri pakukula kwa matenda a myelogenous leukemia (CML).Chochitika chosinthira pakati pa ma chromosome 9 ndi 22 chimapanga chromosome ya Philadelphia, yomwe imatulutsa puloteni ya Bcr-Abl fusion yokhala ndi ntchito ya aberrant kinase yomwe imalimbikitsa kuchuluka kwa maselo mwachangu.Imatinib mesylate imamanga kinase yofunikayi, kuletsa kukula kwa CML.Imatinib mesylate yawonetsedwanso kuti inhibit PDGFR ndi tyrosine kinases yokhudzana ndi c-Kit.Mapangidwe okhala ndi Imatinib mesylate akhala akugwiritsidwa ntchito pochiza khansa zosiyanasiyana.
Imatinib mesylate ndi tyrosine kinase inhibitor.Zodziwika kwambiri za BCR-ABL, puloteni yokhudzana ndi matenda a myelogenous leukemia (CML) ndi mitundu ina ya acute lymphoblastic leukemia (ALL).Ndi yamphamvu komanso yosankha v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Komanso imalepheretsa PDGFR ndi c-kit.Amawonetsa kusankha kwa v-Abl pamagulu ena a tyrosine ndi serine/threonine protein kinases.Kusankha kumalepheretsa PDGF-kukondoweza kukula kwa v-abl-kusintha PB-3 maselo ndi v-sis-kusintha BALB/c 3T3 maselo mu vitro.Imawonetsa zotsatira za antitumor mu mbewa zokhala ndi AMuLV kapena BABL/c 3T3 v-sis cell.Imaletsa kubwereza kwa SARS-CoV ndi MERS-CoV mu vitro (makhalidwe a EC50 ndi 9.823 ndi 17.689 μM, motsatana).
![4--[(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)