Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Zogulitsa Zamalonda Imatinib Mesylate ndi Othandizira Ogwirizana:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4 - [(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS: 106261-49-8
| Dzina la Chemical | Imatinib Mesylate (mtundu wa alpha) |
| Mawu ofanana ndi mawu | imatinib methanesulfonate;STI571 Mesylate;Chithunzi cha CGP-57148B |
| Nambala ya CAS | 220127-57-1 |
| Nambala ya CAT | RF-API19 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | Chithunzi cha C30H35N7O4S |
| Kulemera kwa Maselo | 589.71 |
| Mkhalidwe Wotumiza | Pansi pa Kutentha kwa Ambient |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Wa Crystalline Woyera mpaka Woyera |
| Kusungunuka | Zosavuta kusungunuka m'madzi |
| Chizindikiro cha HPLC | Zitsanzo za nthawi yosungira pachimake zimagwirizana ndi izi |
| Chizindikiro cha IR | Kuchuluka kwa mayamwidwe a infrared kwa zitsanzo kumagwirizana ndi sampuli |
| Melting Point | 214.0 ~ 222.0 ℃ |
| Kutaya pa Kuyanika | ≤0.50% |
| Zotsalira pa Ignition | ≤0.10% |
| Zitsulo Zolemera | ≤20ppm |
| Zogwirizana nazo | (1) Chidetso G: NMT 0.3% |
| (2) Chidetso B: NMT 0.3% | |
| (3) Chidetso C: NMT 0.3% | |
| (4) Chidetso D: NMT 0.3% | |
| (5) Chidetso A: NMT 0.3% | |
| (6) Chidetso H: NMT 0.3% | |
| (7) Chidetso F: NMT 0.3% | |
| (8) Chidetso E: NMT 0.3% | |
| (9) Chidetso chimodzi chachikulu kwambiri: NMT0.1% | |
| Zosungunulira Zotsalira | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Methanol: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Mowa: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Chithunzi cha HPLC | 98.0% ~ 102.0% (C30H35N7SO4 Yowerengedwa pa Anhydrous Basis) |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API;Ph+CML |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Imatinib Mesylate(CAS 220127-57-1) ndi kamolekyu kakang'ono kamene kamalepheretsa c-Abl protein-tyrosine kinase, kinase yofunika kwambiri pakufalikira kwa myelogenous leukemia (CML).Zodziwika kwambiri za BCR-ABL, puloteni yokhudzana ndi matenda a myelogenous leukemia (CML) ndi mitundu ina ya acute lymphoblastic leukemia (ALL).Ndi yamphamvu komanso yosankha v-Abl tyrosine kinase inhibitor (IC50 = 38 nM).Chochitika chosinthira pakati pa ma chromosome 9 ndi 22 chimapanga chromosome ya Philadelphia, yomwe imatulutsa puloteni ya Bcr-Abl fusion yokhala ndi ntchito ya aberrant kinase yomwe imalimbikitsa kuchuluka kwa maselo mwachangu.Imatinib mesylate imamanga kinase yofunikayi, kuletsa kukula kwa CML.Imatinib mesylate yawonetsedwanso kuti inhibit PDGFR ndi tyrosine kinases yokhudzana ndi c-Kit.
![4--[(4-Methylpiperazin-1-yl) methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)