Irbesartan CAS 138402-11-6 Purity>99.0% (HPLC) API Factory Antihypertensive
Wopanga Zinthu, Kuyera Kwambiri, Kupanga Zamalonda
| Dzina la Chemical | Irbesartan |
| Mawu ofanana ndi mawu | BMS-186295;SR-47436;Aprovel;Avapro;2-Butyl-3-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en- 4-mmodzi;2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-imodzi |
| Nambala ya CAS | 138402-11-6 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | Chithunzi cha C25H28N6O |
| Kulemera kwa Maselo | 428.54 |
| Kuchulukana | 1.30±0.10 g/cm3 |
| Kusungunuka mu Madzi | Zosasungunuka m'madzi |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Khalidwe | White to Off-White Crystalline Powder, Wosungunuka pang'ono mu mowa komanso mu methylene chloride, osasungunuka m'madzi. |
| Identification Infrared mayamwidwe | Mawonekedwe a IR amagwirizana ndi mawonekedwe omwe amapezeka ndi Irbesartan RS |
| Chizindikiritso 2 | Nthawi yosungira pachimake chachikulu mu chromatogram ya mayeso imagwirizana ndi Irbesartan RS. |
| Kuyera / Kusanthula Njira | > 99.5% (HPLC) |
| Madzi | <0.50% |
| Zitsulo Zolemera | <0.002% |
| Zotsalira pa Ignition | <0.10% |
| Zogwirizana nazo | (Wolemba HPLC) |
| USP Impurity A | <0.20% |
| Chidetso Chilichonse Chosadziwika | <0.10% |
| Zonse Zonyansa | <0.50% |
| Organic VolatileImpurities | Imakwaniritsa zofunikira za USP |
| Zotsalira Azide | <10ppm |
| Zosungunulira Zotsalira | (Wolemba GC) |
| Ethanol | <5000ppm |
| Toluene | <890ppm |
| Dichloromethane | <3000ppm |
| N, N-Dimethylformamide | <880ppm |
| T-Butyl Methyl Ether | <5000ppm |
| Kuyesa | 98.0 ~ 102.0% (yowerengeredwa pa maziko a anhydrous) |
| Test Standard | Enterprise Standard;USP Standard |
| Kugwiritsa ntchito | API;Antihypertensive;Zochizira matenda oopsa |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi
Irbesartan (CAS: C) ndi angiotensin II receptor antagonist yomwe imagwiritsidwa ntchito makamaka pochiza matenda oopsa.Irbesartan idapangidwa ndi Sanofi Research (tsopano gawo la Sanofi-Aventis).Amagulitsidwa limodzi ndi Sanofi-Aventis ndi Bristol-Myers Squibb pansi pa mayina amalonda Aprovel, Karvea, ndi Avapro.Irbesartan imagwiritsidwa ntchito pochiza kuthamanga kwa magazi.Avapro idakhazikitsidwa ku Germany, UK ndi US chifukwa cha matenda oopsa.Monga onse omwe amatsutsana ndi angiotensin II receptor antagonists, irbesartan imawonetsedwa pochiza matenda oopsa.Irbesartan imathanso kuchedwetsa kupitilira kwa matenda a shuga nephropathy ndipo imawonetsedwanso kuti ichepetse kukula kwa matenda aimpso mwa odwala omwe ali ndi matenda a shuga a 2, matenda oopsa komanso microalbuminuria (kupitirira 30 mg/maola 24) kapena proteinuria.Irbesartan imathanso kuchepetsa kukonzanso kwa magetsi a myocardium, potero kuchepetsa kufa kwa odwala omwe ali ndi matenda oopsa, ndiye mankhwala othandiza kwambiri pochiza matenda oopsa komanso matenda amtima.
