Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Standard High Purity
Manufacturer Supply Irinotecan ndi Intermediates Zogwirizana:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Dzina la Chemical | Irinotecan Hydrochloride |
| Mawu ofanana ndi mawu | Camptothecin II;CPT-II |
| Nambala ya CAS | 100286-90-6 |
| Nambala ya CAT | RF-API50 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C33H39ClN4O6 |
| Kulemera kwa Maselo | 623.15 |
| Melting Point | 250-256 ℃ (Dec.) |
| Zosungirako | Pansi pa Kutentha kwa Ambient |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera kapena Woyera |
| Kusungunuka | Kusungunuka m'madzi ndi methanol, kusungunuka pang'ono mu chloroform, ethanol |
| Chizindikiro cha IR | Kuchuluka kwa mayamwidwe a infrared a chitsanzo choyesera kuyenera kugwirizana ndi mulingo wolozera |
| Chizindikiro cha HPLC | Nthawi yosungira pachimake chachikulu cha yankho lachitsanzo iyenera kufanana ndi mulingo wolozera. |
| Chizindikiritso | Imakwaniritsa zofunikira pamayeso a Chloride Positive reaction |
| Chinyezi (KF) | 7.0% ~ 9.0% w/w |
| Zotsalira pa Ignition | ≤0.10% |
| Zitsulo Zolemera | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl irinotecan | ≤0.15% |
| Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Chidetso Chilichonse Chosadziwika | ≤0.10% |
| Zonse Zonyansa | ≤0.50% |
| Zosungunulira Zotsalira (GC) | |
| Methanol | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Ether: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2 ppm |
| Mabakiteriya Endotoxins | ≤0.29 EU/mg Irinotecan |
| Malire a Microbial | Chiwerengero chonse cha Aerobic Microbial: <1000 cfu/g |
| Nkhungu ndi Yisiti | <100 cfu/g |
| Kuyera / Kusanthula Njira | ≥99.0% (HPLC, pamaziko a anhydrous) |
| Test Standard | United States Pharmacopeia (USP) Standard |
| Kugwiritsa ntchito | Active Pharmaceutical Ingredient (API) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
lrinotecan hydrochloride (CAS 100286-90-6), yopangidwa ndi semi-synthetic, yosungunuka m'madzi yochokera ku camptothecin yamphamvu yolimbana ndi khansa, idakhazikitsidwa ku Japan pochiza khansa ya m'mapapo, yamchiberekero, ndi khomo lachiberekero.lrinotecan imagwiritsa ntchito antitumor ntchito yake poletsa topoisomerase I, puloteni yam'manja yomwe imakhudzidwa pakusunga mawonekedwe a DNA pomasulira, kumasulira, ndi mitosis.lrinotecan imachita de-esterification mu vivo kuti ipereke metabolite yogwira, SN-38, yomwe ili yamphamvu mowirikiza 1000 kuposa kholo.Chithandizo chophatikiza cha irinotecan ndi mankhwala ena omwe amagwiritsidwa ntchito kwambiri ndi khansa, cisplatin, akuti ndiapamwamba kuposa wothandizira yekha.lrinotecan ili m'mayesero azachipatala a m'mimba, m'mawere, khungu, khansa yapakhungu, mesothelioma ndi non-Hodgkin's lymphoma.
