Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Manufacturer Supply Irinotecan ndi Intermediates Zogwirizana:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Dzina la Chemical | Irinotecan Hydrochloride Trihydrate |
| Mawu ofanana ndi mawu | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Nambala ya CAS | 136572-09-3 |
| Nambala ya CAT | RF-API52 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | C33H38N4O6·HCl·3H2O |
| Kulemera kwa Maselo | 677.20 |
| Melting Point | 250.0 ~ 256.0 ℃ (dec.) |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Wachikasu Wachikasu kapena Wachikasu Wakristalo |
| Kuyesa (w/w) | 98.0% ~ 102.0% |
| Purity (HPLC) | ≥99.5% |
| Kusungunuka | Kusungunuka pang'ono m'madzi, ethanol kapena chloroform, Zosasungunuka mu acetone |
| Chizindikiritso | ndi IR ndi HPLC, Conforms |
| Specific Optical Rotation | + 60 ° ~ + 73 ° |
| Madzi | 7.0% ~ 9.0% |
| Zotsalira za Zosungunulira | Imagwirizana ndi Zofunikira za ICH |
| Zotsalira pa Ignition | ≤0.20% |
| Chloride | 5.0% ~ 6.0% |
| Mtengo wa pH | 3.0-5.0 |
| Zitsulo Zolemera | ≤20ppm |
| Zidetso za Munthu Payekha | ≤0.10% |
| Zonse Zonyansa | ≤0.50% |
| Mkhalidwe Wosungira | Sungani pa kutentha kwa 2-8 ° C, muzitsulo zotsekedwa ndikuteteza ku kuwala ndi chinyezi |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Active Pharmaceutical Ingredient (API) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Shanghai Ruifu Chemical Co., Ltd. ndi amene amapanga ndi kugulitsa Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) yokhala ndi khalidwe lapamwamba.
Irinotecan Hydrochloride Trihydrate ndi topoisomerase I inhibitor yomwe imagwiritsidwa ntchito kwambiri pochiza khansa ya m'matumbo ndi khansa yapakhosi, kuteteza kulumikizana kwa chingwe cha DNA pomanga topoisomerase I-DNA complex.lrinotecan hydrochloride, yopangidwa ndi semi-synthetic, yosungunuka m'madzi yochokera ku camptothecin yamphamvu ya anticancer, idakhazikitsidwa ku Japan pochiza khansa ya m'mapapo, yamchiberekero, ndi khomo lachiberekero.lrinotecan imagwiritsa ntchito antitumor ntchito yake poletsa topoisomerase I, puloteni yam'manja yomwe imakhudzidwa pakusunga mawonekedwe a DNA pomasulira, kumasulira, ndi mitosis.lrinotecan imachita de-esterification mu vivo kuti ipereke metabolite yogwira, SN-38, yomwe ili yamphamvu mowirikiza 1000 kuposa kholo.Ngakhale kuti inali yocheperapo poyizoni kuposa camptothecin, odwala ambiri m'mayesero azachipatala adawonetsa zotsatira zoyipa za leukopenia, kutsegula m'mimba, nseru, ndi alopecia.Chithandizo chophatikiza cha irinotecan ndi mankhwala ena omwe amagwiritsidwa ntchito kwambiri ndi khansa, cisplatin, akuti ndiapamwamba kuposa wothandizira yekha.lrinotecan ili m'mayesero azachipatala a m'mimba, m'mawere, khungu, khansa yapakhungu, mesothelioma ndi non-Hodgkin's lymphoma.
