Ketorolac CAS 74103-06-3 Chiyero>98.5% (HPLC)

Ketorolac (CAS: 74103-06-3) ndi mankhwala osagwiritsa ntchito steroid analgesic komanso odana ndi kutupa, omwe amachokera ku pyrrolidone.Mapangidwe a mankhwala ndi pharmacological action ndi ofanana ndi Tolectin, Zoaesthetic acid ndi Indometacin.Poletsa cyclooxygenase, imalepheretsa kaphatikizidwe ndi kumasulidwa kwa prostaglandins, ndipo imapanga zotsatira zotsutsana ndi kutupa.Ikhoza kuchepetsa kutentha komwe kumabwera chifukwa cha kutentha, komwe kumakhudzana ndi kulepheretsa kaphatikizidwe ka prostaglandin m'katikati mwa mitsempha ya mitsempha. kuledzera.Poyesa nyama, mphamvu ya analgesic imakhala yamphamvu kuposa aspirin, indomethacin ndi naproxen. Ndi yofanana kapena yabwino kuposa anti-inflammatory effect ya naproxen ndi indomethacin, phenylbutazone, antipyretic effect pa makoswe ndi yamphamvu kuposa aspirin ndi phenylbutazone. Indomethacin ndi naproxen. Imalepheretsa kuphatikizika kwa mapulateleti opangidwa ndi arachidonic acid ndi collagen.Koma sizilepheretsa kulowetsedwa kwa adenosine diphosphate (ADP).Mankhwalawa amalowa mwamsanga pambuyo pa jekeseni wa intramuscular, ndipo amatha kutengeka kwambiri pambuyo poyang'anira pakamwa.Chakudya chikhoza kuchepetsa kuthamanga kwa mayamwidwe, koma sichimakhudza mlingo wa kuyamwa, ndipo bioavailability ndi 80% ~ 100%.Mphindi 10 pambuyo jekeseni mu mnofu wa 30mg, nthawi zambiri amachepetsa ululu mwachiwonekere.Pambuyo pa mphindi 50, kuchuluka kwa ndende ya plasma kumafika 2.2 g/mL.Pambuyo pa 30 ~ 60 mphindi zoyamwitsa pakamwa, ululuwo mwachiwonekere umamasuka ndipo kuchuluka kwa madzi a m'magazi kumafika pa 1.5 mpaka 4 maola.Theka la moyo wa plasma wa achinyamata ndi pafupifupi maola 5.3, ndipo kwa okalamba ndi pafupifupi maola 7, ndipo zotsatira za analgesic zimatha kusungidwa kwa maola 6-8.91.4% idzatulutsidwa kuchokera ku mkodzo, yotsalayo idzachotsedwa ku ndowe. Odwala omwe ali ndi vuto laimpso, chiwerengero chonse cha plasma chilolezo chimachepa ndipo theka la moyo limatalika, choncho mlingo uyenera kuchepetsedwa.

chipatala ntchito: Ketorolac zimagwiritsa ntchito kwa nthawi yochepa ululu mankhwala kuphatikizapo postoperative ululu (monga pamimba, chifuwa, Urology, matenda achikazi, Dipatimenti ya Stomatology, mafupa opaleshoni ndi ululu) komanso pachimake chigoba minofu ululu chifukwa cha zifukwa zosiyanasiyana, monga sprain, dislocation, fracture ndi zofewa minofu kuvulala, ndi zowawa zina chifukwa cha matenda ena, monga postpartum ululu, pachimake aimpso colic, dzino likundiwawa, sciatica, khansa mochedwa ululu, kupweteka kwa bala, biliary colic, etc .. Ikhoza kugwiritsidwa ntchito m'malo mwa morphine ndi pethidine.