Lesinurad (RDEA 594) CAS 878672-00-5 Purity>99.5% (HPLC) Mayeso 98.0~102.0%
Shanghai Ruifu Chemical Co., Ltd. ndiye wopanga wamkulu wa Lesinurad (RDEA 594) (CAS: 878672-00-5) wokhala ndi mawonekedwe apamwamba.Ruifu Chemical imatha kubweretsa padziko lonse lapansi, mtengo wampikisano, ntchito zabwino kwambiri, zochepa komanso zochulukirapo zomwe zilipo.Gulani Lesinurad ndi Pakati,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Lesinurad |
| Mawu ofanana ndi mawu | 2- [[5-Bromo-4-(4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio]acetic Acid;2- [[5-Bromo-4-(4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio]-Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Stock Status | Mu Stock, Commercial Production |
| Nambala ya CAS | 878672-00-5 |
| Molecular Formula | Chithunzi cha C17H14BrN3O2S |
| Kulemera kwa Maselo | 404.28 g / mol |
| Melting Point | > 171 ℃ (Dec.) |
| Kuchulukana | 1.72±0.10 g/cm3 |
| COA & MSDS | Likupezeka |
| Chiyambi | Shanghai, China |
| Mtundu | Ruifu Chemical |
| Zinthu | Miyezo Yoyendera | Zotsatira |
| Maonekedwe | Ufa Woyera mpaka Woyera | Off-White Powder |
| Chizindikiritso | Nthawi yosungira pachimake chachikulu cha yankho lachitsanzo imagwirizana ndi muyezo wolozera | Zimagwirizana |
| Madzi ndi Karl Fischer | <0.50% | 0.14% |
| Zotsalira pa Ignition | <0.10% | 0.03% |
| Zitsulo Zolemera (Pb) | ≤10ppm | <10ppm |
| Zogwirizana (HPLC) | ||
| Chidetso Chachikulu Chokha Chokha | <0.20% | 0.07% |
| Zonse Zonyansa | <1.00% | 0.24% |
| Kuyera / Kusanthula Njira | >99.5% (HPLC Area) | 99.76% |
| Kuyesa | 98.0-102.0% | 99.6% |
| Infrared Spectrum | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Chithunzi cha NMR | Zimagwirizana ndi Kapangidwe | Zimagwirizana |
| Mapeto | Chogulitsacho chayesedwa ndipo chikugwirizana ndi zomwe zaperekedwa | |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Zaka 15 Zokumana nazo?Tili ndi zaka zopitilira 15 pakupanga ndi kutumiza kunja kwamitundu yambiri yamankhwala apamwamba kwambiri kapena mankhwala abwino.
Misika Yaikulu?Gulitsani kumsika wapakhomo, North America, Europe, India, Korea, Japan, Australia, etc.
Ubwino wake?Ubwino wapamwamba, mtengo wotsika mtengo, ntchito zamaluso ndi chithandizo chaukadaulo, kutumiza mwachangu.
UbwinoChitsimikizo?Njira yoyendetsera bwino kwambiri.Zida zaukadaulo zowunikira zikuphatikizapo NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
Factory Audit?Takulandilani ku fakitale.Chonde panganitu nthawi yokumana.
MOQ?Palibe MOQ.Dongosolo laling'ono ndilovomerezeka.
Nthawi yoperekera? Ngati mkati mwa katundu, kubweretsa masiku atatu kutsimikizika.
Mayendedwe?Ndi Express (FedEx, DHL), ndi Air, ndi Nyanja.
Zolemba?Pambuyo pa ntchito yogulitsa: COA, MOA, ROS, MSDS, ndi zina zotero.
Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
Malipiro Terms?Invoice ya Proforma idzatumizidwa kaye mukatsimikizira kuyitanitsa, ndikuyika zambiri zathu zakubanki.Malipiro a T/T (Telex Transfer), PayPal, Western Union, etc.
Lesinurad (RDEA 594) (CAS: 878672-00-5) idavomerezedwa ndi US Food and Drug Administration (FDA) pa Disembala 22, 2015, kenako idavomerezedwa ndi European Medicines Agency (EMA) pa February 18, 2016. komputala idapangidwa kale ndi Ardea.AstraZeneca idapeza kampaniyo mu 2012, yomwe idapezanso malondawo.Dzina la malonda la mankhwalawa ndi Zurampic® ku United States ndi European Union.Lesinurad ndiye woyamba padziko lonse lapansi wovomerezeka wa urate reuptake transporter (URAT1) inhibitor, kuphatikiza ndi xanthine oxidase inhibitors kuchiza gout yokhudzana ndi hyperuricemia.
Lesinurad, dzina la malonda Zurampic.Lesinurad kuphatikiza xanthine oxidase inhibitor (XOI) ya hyperuricemic gout syndrome.Kachitidwe kake ndikuthandizira impso kutulutsa uric acid, ndipo imagwira ntchito poletsa ntchito ya onyamula omwe amakhudzidwa ndi uric acid reabsorption mu impso.
Lesinurad imalepheretsa ntchito yoyendetsa uric acid (IC50 = 3.36 μM) ya hURAT1 (URAT1 yaumunthu), yomwe imakhala yoposa nthawi 20 zomwe zimalepheretsa rURAT1 (khoswe URAT1) (IC50 = 74.84 μM).Lesinurad imaletsa hURAT1 kudzera muzotsalira za amino acid Phe365.
