3,3′,5-Triiodo-L-Thyronine (Liothyronine; T3) CAS 6893-02-3 Purity>95.0% (HPLC) Factory

3,3',5-Triiodo-L-Thyronine (Liothyronine; T3) (CAS: 6893-02-3) ndi mphamvu yamphamvu ya hormone receptors TRα ndi TRβ agonist ndi Kis ya 2.33 nM kwa hTRα ndi hTRβ, motero.Liothyronine ndi mahomoni opangidwa ndi chithokomiro.Amapangidwa ndi condensation ya L-3-Monoiodotyrosine ndi L-3.5-Diiodotyrosine.Zomwe zili mu minofu ya chithokomiro ndi magazi ndizochepa kwambiri kuposa za thyroxine, koma ntchito yake yachilengedwe ndi 5 mpaka 10 kuposa iyo.T3 imakhala ndi zotsatira zolimbikitsa kagayidwe kazinthu komanso kutulutsa mphamvu;imathanso kulimbikitsa kukula ndi chitukuko.Chithokomiro chodziwika bwino chimatulutsa 30 μg T3 patsiku, 20% ya T3 mu plasma imachokera ku chithokomiro chachindunji, ndipo 80% imachokera ku kusintha kwa plasma T4 m'mphepete mwake.Levothyroxine kapena L-Thyroxine ndi mahomoni opangidwa ndi chithokomiro omwe ali ofanana ndi thyroxine (T4), omwe mwachibadwa amapangidwa ndi maselo a follicular a chithokomiro.Amagwiritsidwa ntchito pochiza kuchepa kwa mahomoni a chithokomiro, komanso nthawi zina kuti apewe kuyambiranso kwa khansa ya chithokomiro.Monga mnzake wobisika mwachilengedwe, levothyroxine ndi chiral mu mawonekedwe a L.Mankhwala okhudzana ndi dextrothyroxine (D-thyroxine) adagwiritsidwa ntchito m'mbuyomu ngati chithandizo cha hypercholesterolemia (ma cholesterol okwera) koma adachotsedwa chifukwa cha zotsatira za mtima.LiothyronineAmagwiritsidwa ntchito panthawi yocheka, kudya, ndi / kapena masewera asanayambe mpikisano chifukwa cha cholinga chapadziko lonse cha magawowa kuti awononge mafuta a thupi, ngakhale m'zaka zaposachedwa T3 yadziwika ngati wothandizira wothandiza panthawi yochuluka komanso kuwonjezeka kwakukulu. za maphunziro (nthawi zambiri molumikizana ndi ma steroids) kuti athe kukonza bwino zakudya zomanga thupi komanso/kapena kuchepetsa kuchuluka kwa mafuta am'thupi panthawi yomwe amadya kwambiri.Liothyronine amagwiritsidwa ntchito kwambiri ndi steroids chifukwa cha kukhudzidwa kwake kwakukulu pa kagayidwe ka thupi lonse.Ndikofunikira kumvetsetsa kuti T3 imakhala yosasankha m'magawo ake olimbikitsa kagayidwe - imachulukitsa kagayidwe ka mafuta, chakudya, ndi mapuloteni onse mofanana.Choncho, kupitirira mlingo wina wa T3, pali chiopsezo chowonjezereka cha kuwonongeka kwa minofu chifukwa cha kuchuluka kwa mapuloteni.Kupyolera mu kugwiritsa ntchito steroids ndi zakudya zosinthidwa bwino, kutayika kwa minofu kumeneku chifukwa cha T3 kungalephereke chifukwa cha kusungirako nayitrogeni ndi mapuloteni osungira katundu wa steroids.Liothyronine imaphatikizidwanso nthawi zambiri ndi othandizira ena otaya mafuta kuti awonjezere zotsatira zake, chifukwa amagwira ntchito mogwirizana ndi othandizira ena otaya mafuta.