Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity
Zopanga Zopanga Zokhala ndi Chiyero Chapamwamba ndi Ubwino Wokhazikika
Dzina la Chemical: Lopinavir
CAS: 192725-17-0
Mphamvu Yapamwamba, Yosankha Peptidomimetic HIV-1 Protease Inhibitor
COVID-19 Related Research Product
API High Quality, Commercial Production
Dzina la Chemical | Lopinavir |
Mawu ofanana ndi mawu | LPV;ABT-378;Kaletra |
Nambala ya CAS | 192725-17-0 |
Nambala ya CAT | RF-API73 |
Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
Molecular Formula | C37H48N4O5 |
Kulemera kwa Maselo | 628.81 |
Kusungirako Nthawi Yaitali | Sungani Nthawi Yaitali pa 2-8 ℃ |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Woyera mpaka Woyera |
Kusungunuka | Zosungunuka mwaulere mu Methanol ndi Ethanol, Zosungunuka mu 2-Propanol |
Chizindikiro cha IR | Mayamwidwe a infrared a chitsanzo choyesera amagwirizana ndi spectrum of reference standard. |
Chizindikiro cha HPLC | Nthawi yosungitsa yachiyeso imafanana ndi yanthawi yolozera |
Mkati mwa Madzi (wolemba KF) | ≤4.0% |
Specific Optical Rotation | -22.0 ° mpaka -26.0 ° |
Zotsalira pa Ignition | ≤0.20% |
Zitsulo Zolemera | ≤20ppm |
Melting Point | 124.0 mpaka 127.0 ℃ |
Phulusa la Sulfate | ≤0.20% |
Residual Solvent (Ethanol) | ≤0.50% |
Zogwirizana nazo | (HPLC, Area%) |
Chidetso 1 | |
Chidetso B (RRT=0.07) | ≤0.20% |
Chidetso I (RRT=1.10) | ≤0.20% |
Chidetso China Chilichonse | ≤0.10% |
Chidetso 2 | Chidetso China Chilichonse ≤0.10% |
Zowonongeka Zonse kuchokera mu Ndondomeko 1 ndi 2 | ≤0.70% |
Zonse Zonyansa | ≤1.0% |
Mayeso (wolemba HPLC) | 98.0% ~ 102.0% |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | Selective Peptidomimetic HIV-1 Protease Inhibitor, COVID-19 Related Research Product |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
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Lopinavir (ABT-378) ndi wamphamvu kwambiri, wosankha peptidomimetic inhibitor wa HIV-1 protease, ndi Kis wa 1.3 mpaka 3.6 pM kwa wild-type ndi mutant HIV protease.Lopinavir imagwira ntchito poletsa kukhwima kwa HIV-1 poletsa kufalikira kwake.Lopinavir ndinso SARS-CoV 3CLpro inhibitor yokhala ndi IC50 ya 14.2 μM.Lopinavir ndi antiretroviral ya gulu la protease inhibitor.Kuletsa kwa HIV-1 protease kumalepheretsa kung'ambika kwa viral polyprotein precursor ndipo kumabweretsa kutulutsidwa kwa ma virioni osakhwima, osapatsirana.Chigawo cha mankhwala osakaniza pochiza HIV/AIDS.Lopinavir, kachilombo kachisanu ndi chimodzi ka HIV protease inhibitor mu kalasi ya "navir", inayambika mogwirizana ndi ritonavir, HIV protease inhibitor ina yomwe yagulitsidwa kale (Abbott, 1996);kupangidwa koyambirira kumeneku kunayambitsidwa monga Kaletra kuti agwiritsidwe ntchito limodzi ndi nucleoside kapena non-nucleoside reverse transcriptase inhibitors pochiza Edzi mwa akulu ndi ana.Lopinavir ndi gulu la peptidomimetic lomwe lili ndi maziko ofanana ndi a ritonavir, pomwe magulu omaliza, makamaka valine yosinthidwa, adayambitsidwa ndi njira zolumikizirana peptide.Lopinavir ndi inhibitor yamphamvu ya HIV-I protease yowonetsa kuthekera kwakukulu motsutsana ndi masinthidwe osagwirizana ndi ritonavir.Mu mitundu ingapo ya nyama, kafukufuku wa pharmacokinetic ndi gulu la lopinavirlritonavir adawonetsa kuti zinthu zochepa za lopinavir zidasinthidwa bwino pamaso pa ritonavir, malinga ndi Cmax komanso nthawi yochitapo kanthu.
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