Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 High Purity

Lopinavir (ABT-378) ndi wamphamvu kwambiri, wosankha peptidomimetic inhibitor wa HIV-1 protease, ndi Kis wa 1.3 mpaka 3.6 pM kwa wild-type ndi mutant HIV protease.Lopinavir imagwira ntchito poletsa kukhwima kwa HIV-1 poletsa kufalikira kwake.Lopinavir ndinso SARS-CoV 3CLpro inhibitor yokhala ndi IC50 ya 14.2 μM.Lopinavir ndi antiretroviral ya gulu la protease inhibitor.Kuletsa kwa HIV-1 protease kumalepheretsa kung'ambika kwa viral polyprotein precursor ndipo kumabweretsa kutulutsidwa kwa ma virioni osakhwima, osapatsirana.Chigawo cha mankhwala osakaniza pochiza HIV/AIDS.Lopinavir, kachilombo kachisanu ndi chimodzi ka HIV protease inhibitor mu kalasi ya "navir", inayambika mogwirizana ndi ritonavir, HIV protease inhibitor ina yomwe yagulitsidwa kale (Abbott, 1996);kupangidwa koyambirira kumeneku kunayambitsidwa monga Kaletra kuti agwiritsidwe ntchito limodzi ndi nucleoside kapena non-nucleoside reverse transcriptase inhibitors pochiza Edzi mwa akulu ndi ana.Lopinavir ndi gulu la peptidomimetic lomwe lili ndi maziko ofanana ndi a ritonavir, pomwe magulu omaliza, makamaka valine yosinthidwa, adayambitsidwa ndi njira zolumikizirana peptide.Lopinavir ndi inhibitor yamphamvu ya HIV-I protease yowonetsa kuthekera kwakukulu motsutsana ndi masinthidwe osagwirizana ndi ritonavir.Mu mitundu ingapo ya nyama, kafukufuku wa pharmacokinetic ndi gulu la lopinavirlritonavir adawonetsa kuti zinthu zochepa za lopinavir zidasinthidwa bwino pamaso pa ritonavir, malinga ndi Cmax komanso nthawi yochitapo kanthu.