Losartan Potassium CAS 124750-99-8 API Factory Antihypertensive High Purity
Perekani Losartan Potassium ndi Zapakati Zofananira Zomwe Zili ndi Ubwino Wapamwamba
Losartan Potaziyamu CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Dzina la Chemical | Losartan potaziyamu |
| Mawu ofanana ndi mawu | DUP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Salt |
| Nambala ya CAS | 124750-99-8 |
| Nambala ya CAT | RF-API98 |
| Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
| Molecular Formula | Chithunzi cha C22H22ClKN6O |
| Kulemera kwa Maselo | 461.01 |
| Melting Point | 263.0 ~ 265.0 ℃ |
| Kusungunuka | Zosungunuka Mwaulere M'madzi ndi Methanol, Zosungunuka Pang'ono mu Acetonitrile. |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera Kapena Woyera Wamakristalo |
| Chizindikiro A | Mayamwidwe a infrared: Ayenera Kufanana ndi Reference Standard |
| Chizindikiro B | Mayamwidwe a Ultraviolet: Ayenera Kufanana ndi Reference Standard |
| Kuyesa kwa Potaziyamu | Ziyenera Kukhala Zabwino |
| M'madzi (KF) | ≤0.50% |
| Zitsulo Zolemera | ≤10ppm |
| Zogwirizana (HPLC) | |
| Chidetso Chilichonse Chamunthu | ≤0.20% |
| Zonse Zonyansa | ≤0.50% |
| Zosungunulira Zotsalira (GC) | |
| Cyclohexane | ≤0.10% |
| Mowa wa Isopropyl | ≤0.20% |
| Njira Yoyesera/Kusanthula | 98.5 ~ 101.0% (HPLC, yowerengedwa pa maziko a anhydrous, opanda zosungunulira) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Tinthu Kukula | 90% Pansi pa 38 Microns |
| Shelf Life | Miyezi 24 |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API, Angiotensin II Receptor Antagonist Antihypertensive |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Losartan Potassium ndiye woyamba wamphamvu komanso wosankha wopanda peptide angiotensin II receptor mtundu 1 (AT1) wobweretsedwa pamsika ngati antihypertensive wapakamwa kamodzi patsiku.Kuphatikizika komwe kumalepheretsa 50% kumangika kwa angiotensin II (IC50) ndi 20 nM.Losartan (40 μM) imakhudza ISC koma imalepheretsa zotsatira za ANGII pa ISC.Losartan imachepetsa kwambiri kuchuluka kwa ma cell a Ang II m'maselo a khansa ya endometrial.Kuphatikiza kwa losartan ndi anti-miR-155 kumakhala ndi antiproliferative kwambiri poyerekeza ndi mankhwala aliwonse okha.Amapangidwa kuti apange 5-carboxylic acid metabolite (EXP3174) ndipo akuti amachepetsa kuthamanga kwa magazi.Pakali pano ikufufuzidwa ngati chithandizo chotheka ku COVID-19 chifukwa cha kuthekera kwake kuchepetsa kapena kuchepetsa zizindikiro za COVID-19.
1. Pochiza matenda oopsa kwambiri, atha kugwiritsidwa ntchito okha kapena kuphatikiza ndi mankhwala ena a antihypertensive (monga okodzetsa).2. Pochiza kulephera kwa mtima, angagwiritsidwe ntchito payekha kapena kuphatikiza ndi cardiotonic kapena diuretic Chemicalbook mankhwala.3. Kupewa sitiroko odwala matenda oopsa ndi kumanzere yamitsempha yamagazi hypertrophy.4. Amagwiritsidwa ntchito kuti achepetse kukula kwa nephropathy kwa odwala omwe ali ndi matenda a shuga a 2 omwe amagwirizana ndi nephropathy ndi matenda oopsa.
