Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Yapakatikati
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Dzina la Chemical | Methyl (S) -2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate |
Mawu ofanana ndi mawu | Methyl (S) -2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS, 3S) -α--[(tert-Butyloxycarbonyl)aMino] -2-oxo-3-pyrrolidinepropanoic asidi Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate |
Nambala ya CAS | 328086-60-8 |
Nambala ya CAT | RF-PI317 |
Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
Molecular Formula | C13H22N2O5 |
Kulemera kwa Maselo | 286.33 |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Woyera mpaka Woyera |
Chizindikiro A | IR: Zofanana ndi Reference Substance |
Chizindikiro B | Nthawi Yosungira: Zofanana ndi Zolozera |
Kutaya pa Kuyanika | ≤1.0% |
Zotsalira pa Ignition | ≤0.20% |
Chidetso Chimodzi | ≤0.50% |
Zonse Zonyansa | ≤2.0% |
Zitsulo Zolemera (Pb) | ≤20ppm |
Chiyero | ≥98.0% |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | Wapakatikati wa PF-07321332 Paxlovid (CAS 2628280-40-8) ndi Boceprevir (CAS 394730-60-0) |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
Methyl (S) -2- (Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) ndi wapakatikati wa PF-07321332 Paxlovid (CAS 2628280-40 -8) ndi Boceprevir (CAS 394730-60-0).PF-07321332, chigawo chachikulu cha Paxlovid (PF-07321332 ndi Ritonavir) chomwe ndi kafukufuku wa COVID-19 oral antiviral candidate, ndi oral bioavailable 3C-like protease (3CLPRO) inhibitor yokhala ndi mphamvu zolimbana ndi kachilombo ka SARS-CoV-2. ndi COVID-19.Pa Nove 6th 2021, Pfizer adalengeza kuti Paxlovid adachepetsa kwambiri kugonekedwa m'chipatala ndi kufa, kutengera kuwunika kwakanthawi kwa Phase 2/3 EPIC-HR (Kuwunika kwa Protease Inhibition ya COVID-19 mu Odwala Oopsa) mwachisawawa, osawona kawiri. mwa odwala omwe sanagoneke m'chipatala omwe ali ndi COVID-19, omwe ali pachiwopsezo chachikulu chodwala kwambiri.Boceprevir (EBP-520) ndi HCV protease inhibitor (Ki=14 nM) pochiza matenda a hepatitis C.Boceprevir yokhala ndi pegylated interferon ndi ribavirin (PegIFN/RBV) idathandizira kusintha kwanthawi yayitali kwa odwala omwe ali ndi genotype 1 HCV.Boceprevir imagwirizana ndi immunosuppressive therapy (IT) poletsa cytochrome P450 3A enzyme.