N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Kufotokozera Kwachidule:

Dzina Lamankhwala: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Kuyera: > 99.0% (HPLC)

Maonekedwe: Ufa Wachikasu Wopepuka mpaka Wachikasu

Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Titumizireni imelo

Tsatanetsatane wa Zamalonda

Zogwirizana nazo

Zolemba Zamalonda

Kufotokozera:

Ruifu Chemical Supply Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-imodzi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineChithunzi cha CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Chemical Properties:

Dzina la Chemical	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Mawu ofanana ndi mawu	N-(3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl) amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Nambala ya CAS	162012-67-1
Nambala ya CAT	RF-PI2026
Stock Status	Mu Stock, Kupanga Kukula Mpaka Matani
Molecular Formula	C14H7ClF2N4O2
Kulemera kwa Maselo	336.68
Kumverera	Simamva Kutentha, Kutentha
Melting Point	242.0 ~ 244.0 ℃
Boiling Point	489 ℃
Kuchulukana	1.616
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Wachikasu Wopepuka mpaka Wachikasu
Kuyera / Kusanthula Njira	>99.0% (HPLC)
Kutaya pa Kuyanika	<0.50%
Zotsalira pa Ignition	<0.20%
Zogwirizana nazo
Chidetso cha Munthu Payekha	<0.50%
Zonse Zonyansa	<1.00%
Zitsulo Zolemera	≤20ppm
Infrared Spectrum	Zimagwirizana ndi Kapangidwe
Proton NMR Spectrum	Zimagwirizana ndi Kapangidwe
Test Standard	Enterprise Standard
Kugwiritsa ntchito	Wapakatikati wa Afatinib Dimaleate (CAS: 850140-73-7)

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala

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Ubwino:

FAQ:

Ntchito:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) ndi yapakatikati mwa kaphatikizidwe ka Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate ndi mtundu wa mchere wa Afatinib.Afatinib ndi m'badwo wachiwiri, woperekedwa pakamwa, wosasinthika woletsa wa ErbB banja la tyrosine kinases.Mechanism of ActionAfatinib imatsitsa chizindikiro cha ErbB pomangirira mwamphamvu ku madera a kinase a epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 ndi HER4, zomwe zimapangitsa kuletsa kosasinthika kwa tyrosine kinase autophosphorylation;imalepheretsanso transphosphorylation ya HER3.Afatinib amavomerezedwa ngati monotherapy pochiza EGFR tyrosine kinase inhibitor (TKI) -akuluakulu osaphunzira omwe ali ndi malo apamwamba kapena DefinitionChEBI: Mchere wa maleate wopezedwa mwa kuphatikiza afatinib ndi ma molar awiri ofanana ndi maleic acid.Amagwiritsidwa ntchito pochiza odwala omwe ali ndi khansa ya m'mapapo yopanda maselo ang'onoang'ono a metastatic.