N-Hydroxysuccinimide (HOSu) CAS 6066-82-6 Coupling Reagent Purity >99.0% (HPLC)

N-Hydroxysuccinimide (HOSu) (CAS: 6066-82-6), reagent yokonzekera esters yogwira amino acid.Peptide solid phase synthesis yolumikizira wothandizira.
N-Hydroxysuccinimide nthawi zambiri amagwiritsidwa ntchito kuthandizira kugwirizana kwa peptide ya carbodiimide-mediated popanga ester yogwira yapakatikati kudzera mwa condensation ya pamwamba carboxyl gulu ndi NHS.NHS-reactive ester intermediate imatha kugwidwa ndi nucleophilic ndi ma primary amines ndipo imapangitsa kuti pakhale mgwirizano wokhazikika wa amide pakati pa biomaterial pamwamba ndi N-terminus ya peptide.
N-Hydroxysuccinimide ndi hydroxylated succinimide yomwe imagwiritsidwa ntchito kwambiri poyambitsa ma carboxylic acid ku NHS-esters kulimbikitsa kulumikizana ndi ma nucleophiles.Njirayi imagwiritsidwa ntchito kwambiri poyambitsa mitundu ya asidi yaulere ya fluorophores polimbikitsa kulumikizana kwa ma fluorophore ndi zotsalira za amine zamapuloteni.Kugwiritsa ntchito NHS ester activation kwafotokozedwanso mu kaphatikizidwe ka N-acyl amino acid.
Amagwiritsidwa ntchito popanga amino acid protectant, semisynthetic kanamycin ndi pharmaceutical intermediates.N-hydroxybutyldiimide ndi zotumphukira zake ndizofunikira pakupangira ma peptides, maantibayotiki, ma amino acid ndi mapuloteni.N-hydroxybutyldiimide imagwiritsidwa ntchito pokonzekera yogwira ntchito. esters, ndi kuletsa kwa mphamvu ya optically yophatikizika ya peptide ili ndi ma NTCHITO osiyanasiyana muzamankhwala, komanso ndi mankhwala oyambira.
N-Hydroxysuccinimide imagwiritsidwa ntchito popititsa patsogolo njira ya carbodiimide.Amagwiritsidwanso ntchito kuyambitsa gulu la carboxyl ndikuchitapo kanthu ndi amine kupanga amide.Imakhudzidwa ndikukonzekera kwa N-hydroxymaleimide-styrene copolymer.