N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC High Quality
Perekani ndi Kuyera Kwambiri ndi Ubwino Wokhazikika
Dzina la Mankhwala: N (4) -Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
Metabolite yogwira ya Molnupiravir, yolonjeza ya COVID-19 inhibitor
| Dzina la Chemical | N(4)-Hydroxycytidine |
| Mawu ofanana ndi mawu | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Nambala ya CAS | 3258-02-4 |
| Nambala ya CAT | RF-PI309 |
| Stock Status | Mu Stock, Production Scale Up to Kilograms |
| Molecular Formula | Chithunzi cha C9H13N3O6 |
| Kulemera kwa Maselo | 259.22 |
| Melting Point | 169.0 ~ 172.0 ℃ |
| Kusungunuka | Kusungunuka mpaka 100 mM mu DMSO ndi 50 mM mu Madzi |
| Kuchulukana | 1.93±0.1 g/cm3 |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera mpaka Woyera |
| NMR | Zogwirizana ndi Kapangidwe |
| Kuyera / Kusanthula Njira | >98% (HPLC) |
| Kutaya pa Kuyanika | ≤1.0% |
| Chidetso Chimodzi | ≤0.50% |
| Zitsulo Zolemera | ≤20ppm |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | Metabolite yogwira ya Molnupiravir (EIDD-2801), inhibitor ya COVID-19 |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.
N(4)-Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) ndi metabolite yogwira ya EIDD-2801, yolonjeza COVID-19 inhibitor.EIDD-1931 (NHC) ili ndi zochita zambiri zolimbana ndi ma virus angapo, kuphatikiza SARS-CoV-2, MERS-CoV, SARS-CoV, ndi gulu lofananira la zoonotic 2b kapena 2c Bat-CoVs okhala ndi pafupifupi IC50 ya 0.15 μM, komanso kuchuluka kwa potency motsutsana ndi coronavirus yolimbana ndi kusintha kwa nucleoside analog inhibitor remdesivir.Mu mbewa zomwe zili ndi SARS-CoV kapena MERS-CoV, onse prophylactic ndi achire kasamalidwe ka Molnupiravir (EIDD-2801), pakamwa bioavailable NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), bwino pulmonary ntchito , ndi kuchepetsa chiwerengero cha ma virus komanso kuchepa thupi.Kuchepetsa zokolola za MERS-CoV mu vitro ndi mu vivo zimalumikizidwa ndi kuchuluka kwa kusintha kwakusintha kwa ma virus koma osati ma cell a RNA, kuthandizira njira yakupha mutagenesis mu CoV.Mphamvu ya NHC/EIDD-2801 yolimbana ndi ma coronavirus angapo komanso kupezeka kwapakamwa kumawonetsa momwe angagwiritsire ntchito ngati antivayirasi yolimbana ndi SARS-CoV-2 ndi ma coronavirus ena amtsogolo a zoonotic.
