Naproxen CAS 22204-53-1 Chiyero>99.5% (HPLC)

Naproxen (CAS: 22204-53-1) ndi mankhwala osagwiritsa ntchito steroidal odana ndi kutupa, ndi PG synthase inhibitor, yomwe imatha kuletsa prostaglandin synthetase, imakhala ndi zotsatira za analgesic ndi antipyretic, kuyamwa m'kamwa kumathamanga komanso kokwanira, 2 mpaka Maola 4 mutatha kumwa, ndende ya plasma imafika pachimake, m'magazi opitilira 99% amamanga mapuloteni a plasma, t1/2 ndi maola 13 mpaka 14, pafupifupi 95% amatulutsidwa mumkodzo ndi prototype ndi metabolites.Amagwiritsidwa ntchito pochiza nyamakazi ya nyamakazi ndi nyamakazi, osteoarthritis, ankylosing spondylitis, gout, nyamakazi, tenosynovitis.itha kugwiritsidwanso ntchito pochepetsa ululu wobwera chifukwa cha kusweka kwa minofu ndi mafupa, kusokonezeka, kuwonongeka ndi dysmenorrhea.Koma tisaiwale kuti monga ena sanali steroidal odana ndi yotupa mankhwala, yemweyo kwambiri m`mimba chokhwima zimachitikira nthawi iliyonse pamene kumwa naproxen pa mankhwala, kotero yogwira gastroduodenal chilonda odwala kupachikidwa, ena m`mimba thirakiti matenda odwala ayenera kutenga izi. mankhwala moyang'aniridwa ndi achipatala.Naproxen amapangidwa kuchokera ku 2-methoxynaphthalene ndi (+)-isomer yopezedwa ndi kusamvana ndi cinchonidine (61).Idayambitsidwa ku United States mu 1976 ndipo, monga mankhwala a generic, yakhala pakati pa ma NSAID otchuka kwambiri.Amagulitsidwa ngati S-(+) -enantiomer, koma chochititsa chidwi, mchere wa sodium wa (-) -isomer ulinso pamsika ngati Anaprox.Monga inhibitor ya prostaglandin biosynthesis, imakhala yamphamvu kuwirikiza ka 12 kuposa aspirin, imakhala yamphamvu kuwirikiza ka 10 kuposa phenylbutazone, katatu kapena kanayi kuposa ibuprofen, komanso kuwirikiza kanayi kuposa fenoprofen, koma imakhala yamphamvu kuwirikiza 300 kuposa mankhwala indomethacin.