Paxlovid: zomwe tikudziwa za piritsi la Pfizer's Covid-19

Pfizer ikufuna chilolezo chogwiritsa ntchito mwadzidzidzi kuchokera ku FDA pa buku lake la Covid-19 antiviral piritsi Paxlovid.
Gawani Nkhani

Pambuyo pa kuvomerezedwa ndi Merck antiviral molnupiravir ku UK, Pfizer wakonzeka kutenga mapiritsi ake a Covid-19, Paxlovid, pamsika.Sabata ino, wopanga mankhwala ku US adapempha chilolezo chogwiritsa ntchito mwadzidzidzi kuchokera ku US Food and Drug Administration (FDA) kwa munthu yemwe ali ndi kachilombo ka HIV mwa anthu omwe ali ndi Covid-19, omwe ali pachiwopsezo chachikulu chogonekedwa m'chipatala kapena kumwalira. Pfizer alinso adayamba ntchito yofunafuna chilolezo chovomerezeka m'maiko ena kuphatikiza UK, Australia, New Zealand ndi South Korea, ndipo akufuna kutumiza ma fomu owonjezera.Kodi Paxlovid amagwira ntchito bwanji? ritonavir, mankhwala ochepetsa mphamvu ya kachilombo ka HIV omwe nthawi zambiri amagwiritsidwa ntchito pochiza HIV.Chithandizochi chimasokoneza kubwereza kwa SARS-CoV-2 m'thupi pomangiriza ku 3CL-ngati protease, enzyme yofunikira pakugwira ntchito kwa kachilomboka komanso kuberekana.
Malinga ndi kuwunika kwakanthawi, a Paxlovid adachepetsa chiwopsezo chogonekedwa m'chipatala chokhudzana ndi Covid-19 kapena kufa ndi 89% mwa iwo omwe adalandira chithandizo mkati mwa masiku atatu chiyambireni zizindikiro.Mankhwalawa adapezeka kuti ndi othandiza kwambiri - 1% yokha ya odwala omwe adalandira Paxlovid adagonekedwa m'chipatala tsiku la 28 poyerekeza ndi 6.7% ya omwe adatenga nawo gawo la placebo-kuti kuyesa kwake kwa Phase II/III kudatha msanga ndipo kugonjera ku FDA kudaperekedwa posachedwa kuposa. kuyembekezera.Komanso, ngakhale kuti imfa za 10 zidanenedwa pa mkono wa placebo, palibe chomwe chinachitika pakati pa omwe adalandira Paxlovid.Monga molnupiravir, Paxlovid amaperekedwa pakamwa, kutanthauza kuti odwala a Covid-19 amatha kumwa mankhwalawa kunyumba akamadwala.Chiyembekezo ndichakuti ma antivayirasi atsopano ngati aku Merck ndi Pfizer alola kuti anthu omwe ali ndi vuto la coronavirus locheperako kapena laling'ono alandire chithandizo posachedwa, kuletsa kukula kwa matenda ndikuthandizira kupewa zipatala kuti zisathe.

Mpikisano wa mankhwala a Covid-19 aMerck's molnupiravir, piritsi loyamba lovomerezeka la Covid-19, akuti akhoza kusintha masewera kuyambira pomwe kafukufuku adapeza kuti yachepetsa kugonekedwa m'chipatala komanso chiwopsezo cha kufa ndi pafupifupi 50%.Koma izi sizikutanthauza kuti Pfizer antiviral zopereka sizikhala ndi malire pamsika.Kuwunika kwakanthawi kogwira ntchito kwa molnupiravir kukulonjeza, koma kuchepetsedwa kwakukulu kwachiwopsezo komwe a Pfizer akuwonetsa kukuwonetsa kuti mapiritsi ake amathanso kutsimikizira chida chankhondo chankhondo cha maboma polimbana ndi mliriwu. mankhwala antiviral.Akatswiri ena adandaula kuti njira ya molnupiravir yolimbana ndi Covid-19 - kutsanzira mamolekyu a RNA kuti apangitse kusintha kwa ma virus - atha kuyambitsanso masinthidwe owopsa mkati mwa DNA yamunthu.Paxlovid, mtundu wina wa antiviral wotchedwa protease inhibitor, sanawonetse zizindikiro za "mutagenic DNA interactions", adatero Pfizer.