Octreotide Acetate CAS 83150-76-9 Peptide Purity (HPLC) ≥98.0% API High Quality

Octreotide Acetate (Sandostatin) ndi analogue ya peptide yopangidwa ya hormone somatostatin, ndi analogue ya somatostatin yomwe imakhala nthawi yayitali yomwe imasonyezedwa kuwongolera zizindikiro mu zotupa za acromegaly ndi gastroenteropancreatic.Zina zomwe zingagwiritsidwe ntchito pofufuzidwa ndi matenda a shuga, psoriasis ndi matenda a Alzheimer's.Octreotide Acetate (Sandostatin) ndi peptide yopangidwa ndi analogue ya hormone somatostatin.Zochita zake zimaphatikizapo kuletsa kwa pituitary secretion of growth hormone komanso kulepheretsa katulutsidwe ka pancreatic islet cell ka insulin ndi glucagon.Mosiyana ndi somatostatin, yomwe imakhala ndi theka la moyo wa plasma mphindi zochepa, Octreotide imakhala ndi theka la moyo wa plasma wa 1 mpaka 2 hours.Excretion wa mankhwala ndi makamaka aimpso.Octreotide imachepetsa kusuntha kwa m'mimba ndikuletsa kugunda kwa ndulu.

Mankhwala a peptide Novartis Sandostatin (Octreotide Acetate), ndiwopangidwa mwachilengedwe wopangidwa ndi somatostatin octapeptide, amakhalabe ndi zotsatira za pharmacological zofanana ndi za somatostatin, ndipo zotsatira zake zimakhala zokhalitsa.Zizindikiro za Octreotide Acetate zimaphatikizapo acromegaly;Kuchepetsa zizindikiro ndi zizindikiro zogwirizana ndi gastroenteropancreatic endocrine neoplasia;Ndipo mphamvu ya Carcinoid Tumors yopereka matenda a carcinoid, zotupa za VIP, ndi zotupa za glucagon.Kuphatikiza apo, Octreotide Acetate ya gastrinomas/Zollinger-Ellison syndrome (nthawi zambiri imaphatikizidwa ndi proton pump inhibitors kapena H2 receptor blockers), Insulinomas (kupewa kusanachitike kwa hypoglycemia ndi kukonza shuga wabwinobwino wamagazi), kuchuluka kwamphamvu kwa kukula kwa chotupa chomwe chimatulutsa timadzi tating'onoting'ono. pafupifupi 50%.

Octreotide Acetate ndi mankhwala a inshuwaransi yadziko lonse a Gulu B, omwe ndi opangidwa ndi octapeptide opangidwa kuchokera ku somatostatin, poyerekeza ndi somatostatin yachilengedwe, theka la moyo wa somatostatin mwachiwonekere ndi lalitali ndipo limakhala ndi zotsatira zofanana za pharmacological, kuphatikizapo kuletsa kukula kwa hormone, kuletsa. Chapamimba acid, pancreatic enzyme, glucagon ndi insulin secretion, ndi kuchepa kwa visceral magazi, kuchepa kwa m'mimba motility.Poyerekeza ndi mbadwa ya somatostatin, octreotide imakhala ndi theka la moyo wautali, imasankha kwambiri kuletsa katulutsidwe ka mahomoni okula kuposa kuletsa katulutsidwe ka insulini, ndipo sichimayambitsa kuchulukitsa kwa mahomoni.1, Kuwongolera opaleshoni kapena mankhwala opatsirana pogwiritsa ntchito ma radiation sangathe kulamulira mokwanira matendawa kwa odwala omwe ali ndi zizindikiro za acromegaly ndi kuchepetsa kukula kwa hormone (GH) insulini-monga kukula kwa factor factor -1 (1GF-1) plasma.Sandostatin itha kugwiritsidwanso ntchito pochiza odwala acromegaly omwe sangathe kapena sakufuna kuchitidwa opaleshoni, kapena kuchiza odwala omwe ali ndi acromegaly omwe sanalandire chithandizo chamankhwala.2. Kuchepetsa zizindikiro zomwe zimagwirizanitsidwa ndi zotupa za endocrine za gastroenteropancreatic (GEP) monga zotupa za carcinoid ndi zizindikiro za matenda a carcinoid.Sandostatin si mankhwala oletsa khansa ndipo samachiritsa odwalawa.3, Kupewa zovuta pambuyo pa opaleshoni ya kapamba.4, chiwindi matenda enaake odwala ndi chapamimba-esophageal variceal magazi chifukwa cha chithandizo mwadzidzidzi, hemostasis ndi kupewa rebleeding, Sandostatin ayenera pamodzi ndi endoscopic sclerotherapy ndi zina zapadera.