Olaparib AZD-2281 CAS 763113-22-0 Purity ≥99.0% API Factory
Kuyera Kwambiri, Kupanga Zamalonda
Olaparib ndi Othandizira Ogwirizana:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl) piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Dzina la Chemical | Olaparib |
| Mawu ofanana ndi mawu | AZD-2281;KU0059436;Lynparza;4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-chimodzi;1-(Cyclopropylcarbonyl) -4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin |
| Nambala ya CAS | 763113-22-0 |
| Nambala ya CAT | RF-API103 |
| Stock Status | Mu Stock, Kupanga Kufikira Mazana a Kilogram |
| Molecular Formula | Chithunzi cha C24H23FN4O3 |
| Kulemera kwa Maselo | 434.46 |
| Kusungunuka | Zosungunuka mu DMSO |
| Mtundu | Ruifu Chemical |
| Kanthu | Zofotokozera |
| Maonekedwe | Ufa Woyera mpaka Woyera |
| Kuzindikiritsa ndi 1H NMR | Tsatirani dongosolo |
| Chithunzi cha LC-MS | Tsatirani dongosolo |
| Kuyera / Kusanthula Njira | ≥99.0% (mwa LC-MS) |
| Chinyezi (KF) | ≤0.50% |
| Chidetso Chimodzi | ≤0.50% |
| Zonse Zonyansa | ≤1.0% |
| Zitsulo Zolemera (monga Pb) | ≤20ppm |
| Test Standard | Enterprise Standard |
| Kugwiritsa ntchito | API;PARP Inhibitor |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni Drum, 25kg/ng'oma, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi.
Olaparib (CAS: 763113-22-0), wamphamvu kwambiri komanso wosankha PARP-inhibitor.Mu Disembala 19, 2014, a FDA adavomereza buku la mankhwala oletsa khansa Olaparib (Lynparza) kuti akhale monotherapy kwa odwala omwe ali ndi khansa ya m'mawere omwe adalandira mankhwala a chemotherapy osachepera katatu kapena odwala omwe akuwakayikira kuti asintha kusintha kwa BRCA.Nthawi yomweyo, FDA idavomereza kuchulukitsidwa ndi kugawa kwa zida zowunikira kuti zizindikire masinthidwe mu BRCA1 ndi BRCA2, BRCAanalysis CDx.Olaparib ndiye mankhwala oyamba a PARP inhibitor omwe avomerezedwa ndi FDA.Mu February 2, 2015, European Union Food and Drug Administration (EMA) idavomerezanso Olaparib kuti alowe msika m'maiko 28 a European Union kuphatikiza Iceland, Liechtenstein ndi Norway.Koma zisonyezo za EMA ndi FDA zovomerezeka ndizosiyana pang'ono;yoyamba ndi ya milandu ya kusintha kwa majini a BRCA, komanso chithandizo chothandizira odwala omwe ali ndi khansa yapakatikati ya epithelial ovarian omwe adalandirapo kale mankhwala a chemotherapy okhala ndi platinamu ndikuwonetsa kuyankha komanso kuyambiranso.
