Omeprazole Sulfide CAS 73590-85-9 Purity>99.0% (HPLC) Factory

Omeprazole Sulfide (CAS: 73590-85-9) ndi yapakatikati yomwe imagwiritsidwa ntchito popanga chapamimba proton pump inhibitors, Omeprazole (CAS: 73590-58-6) ndi Esomeprazole (CAS: 119141-88-7), Esomeprazole Sodium ( CAS: 161796-78-7).Monga chinthu chowononga, akuti ndi inhibitor yochita mwachindunji ya cytochrome P450 2C19 mu ma microsomes a chiwindi chamunthu (IC50 = 9.7 μM).Omeprazole sulfide ndi metabolite wa Omeprazole.Esomeprazole Sodium ndi mtundu wa mchere wa sodium wa esomeprazole.Ndi mankhwala omwe amagwiritsidwa ntchito polimbana ndi zilonda zam'mimba, omwe poyamba adapangidwa bwino ndi kampani ya Swedish Astra Zeneca poyamba.Ndi ya proton pump inhibitor.Proton pump inhibitor ndiye chisankho choyambirira chochiza zilonda zam'mimba, matenda a reflux a gastroesophageal ndi matenda ena okhudzana ndi asidi.Pakali pano, PPI yomwe imagwiritsidwa ntchito nthawi zambiri imaphatikizapo mitundu isanu: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole ndi Esomeprazole.Monga PPI yoyamba, mphamvu ya omeprazole pochiza matenda okhudzana ndi asidi yadziwika kwambiri.Esomeprazole ndi S-isomer ya Omeprazole, yomwe imatha kuchepetsa katulutsidwe ka m'mimba mwa njira yolunjika.Ndilo choletsa chapadera cha proton pump inhibitor mu cell ya parietal.Chifukwa cha ubwino wa kagayidwe kake ka esomeprazole, imakhala ndi bioavailability yapamwamba komanso pharmacokinetics yosasinthasintha kuposa mnzake, Omeprazole Sodium, kuonjezera mankhwala omwe amafika pampu ya proton.Udindo wake wowongolera asidi wa m'mimba ndi wabwino kwambiri kuposa zoletsa zina zapampu za proton monga Lansoprazole, Pantoprazole, ndi Rabeprazole.