Pazopanib Hydrochloride CAS 635702-64-6 Purity >99.0% (HPLC) API Factory

Kufotokozera Kwachidule:

Dzina la Mankhwala: Pazopanib Hydrochloride

CAS: 635702-64-6

Maonekedwe: Ufa Woyera mpaka Wachikasu Pang'ono

Kuyera: > 99.0% (HPLC)

Tyrosine kinase receptor inhibitor pochiza khansa yapamwamba yaimpso kapena sarcoma yapamwamba kwambiri.

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com

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Kufotokozera:

Zopanga Zopanga Zokhala ndi Chiyero Chapamwamba ndi Ubwino Wokhazikika
Dzina la Mankhwala: Pazopanib Hydrochloride
CAS: 635702-64-6
Tyrosine kinase receptor inhibitor pa chithandizo chapamwamba cha renal cell carcinoma kapena sarcoma yapamwamba yofewa yomwe idalandira kale mankhwala amphamvu.
API High Quality, Commercial Production

Chemical Properties:

Dzina la Chemical	Pazopanib Hydrochloride
Mawu ofanana ndi mawu	Pazopanib HCl;GW786034 HCl;Votrient;5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide Hydrochloride
Nambala ya CAS	635702-64-6
Nambala ya CAT	RF-API93
Stock Status	Mu Stock, Kupanga Kufikira Mazana a Kilogram
Molecular Formula	Chithunzi cha C21H23N7O2S.ClH
Kulemera kwa Maselo	473.987
Kusungunuka	DMSO
Melting Point	300.0 ~ 304.0 ℃
Mtundu	Ruifu Chemical

Zofotokozera:

Kanthu	Zofotokozera
Maonekedwe	Ufa Woyera mpaka Wachikasu Pang'ono
Chizindikiritso	Kuchuluka kwa mayamwidwe a infraed pachiyeso choyeserera kumagwirizana ndi muyezo
Zotsalira pa Ignition	≤0.50%
Chidetso Chilichonse Chamunthu	≤0.30%
Zonse Zonyansa	≤1.50%
Zitsulo Zolemera	≤10ppm
Kuyera / Kusanthula Njira	≥99.0% (HPLC)
Test Standard	Enterprise Standard
Kugwiritsa ntchito	API, Tyrosine kinase receptor inhibitor

Phukusi & Kusungira:

Phukusi: Botolo, Aluminiyamu zojambulazo thumba, makatoni ng'oma, 25kg / Drum, kapena malinga ndi zofuna za kasitomala.

Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala, chinyezi ndi tizilombo towononga.

Ubwino:

FAQ:

Ntchito:

Pazopanib Hydrochloride (CAS 635702-64-6) ndi multi-tyrosine kinase inhibitor ya vascular endothelial growth factor receptor (VEGFR) -1, VEGFR-2, VEGFR-3, platelet-derived growth factor receptor (PDGFR) -α ndi - β, fibroblast kukula factor receptor (FGFR) -1 ndi -3, cytokine receptor (Kit), interleukin-2 receptor-inducible T-cell kinase (Itk), lymphocyte-specific protein tyrosine kinase (Lck), ndi transmembrane glycoprotein receptor tyrosine kinase (cFms).Mu vitro, pazopanib inhibited ligand-induced autophosphorylation ya VEGFR-2, Kit, and PDGFR-beta receptors.Mu vivo, pazopanib analetsa VEGF-induced VEGFR-2 phosphorylation mu mbewa mapapo, angiogenesis mu chitsanzo mbewa, ndi kukula kwa ena chotupa xenografts anthu mu mbewa.Inavomerezedwa ndi renal cell carcinoma ndi US Food and Drug Administration mu 2009 ndipo imagulitsidwa pansi pa dzina la malonda Votrient ndi wopanga mankhwalawa, GlaxoSmithKline.Votrient ndi kinase inhibitor yomwe ikuwonetsedwa pochiza odwala omwe ali ndi: 1) advanced renal cell carcinoma.2) sarcoma yapamwamba yofewa yomwe idalandira kale chemotherapy.