Polymyxin B Sulfate CAS 1405-20-5 Assay Microbiological ≥6500 IU/mg Factory
Shanghai Ruifu Chemical Co., Ltd. ndiwopanga kutsogolera komanso ogulitsa Polymyxin B Sulfate (CAS: 1405-20-5) yokhala ndipamwamba kwambiri.Titha kupereka COA, kutumiza padziko lonse lapansi, zochepa komanso zochulukirapo zomwe zilipo.Ngati mukufuna Polymyxin B Sulfate,Please contact: alvin@ruifuchem.com
| Dzina la Chemical | Polymyxin B sulfate |
| Mawu ofanana ndi mawu | Polymyxin B Sulfate mchere;Aerosporin;Mastimyxin;PXNS;PMB;Zithunzi za Poly-RX |
| Stock Status | Mu Stock, Mphamvu Yopanga Matani 10 pachaka |
| Nambala ya CAS | 1405-20-5 |
| Molecular Formula | C55H96N16O13·2H2SO4 |
| Kulemera kwa Maselo | 1301.56 |
| Melting Point | 217.0 ~ 220.0 ℃ (Dec.) |
| Zomverera | Hygroscopic.Simamva Kuwala ndi Kutentha |
| Kusungunuka kwamadzi | Zosungunuka m'madzi, 50 mg/mL.Zosungunuka pang'ono mu Ethanol |
| COA & MSDS | Likupezeka |
| Chitsanzo | Likupezeka |
| Mtundu | Ruifu Chemical |
| Zinthu | Zofotokozera | Zotsatira |
| Maonekedwe | Choyera Kapena Chapafupi Ndi Ufa Wa Crystalline | Zimagwirizana |
| Chizindikiritso A. Nthawi zosungirako nsonga zazikulu kuchokera ku yankho lachitsanzo zimagwirizana ndi zomwe zapezeka muyeso la ma Polymyxins. | Zimagwirizana | |
| PH (2%) | 5.0-7.0 | 5.7 |
| PH (0.5%) | 5.0-7.5 | 5.5 |
| Phulusa la Sulfate | ≤0.75% |
|
| Kusinthasintha Kwachindunji [α]20/D | -78.0°~-90.0°(C=2, H2O) (Calcd. pa Anh. Substance) | -85.0 ° |
| Sulphate | 15.5-17.5% | 16.65% |
| Kutaya pa Kuyanika | ≤6.00% | 3.0% |
| Zotsalira pa Ignition | ≤0.10% | 0.02% |
| Zitsulo Zolemera | ≤20ppm | ≤20ppm |
| Phenylalanine | 9.0-12.0% | 9.8% |
| Total Viabel Aerobic Count | ≤10cfu/g | ≤10cfu/g |
| Zogwirizana, HPLC |
|
|
| Chidetso cha Munthu Payekha | ≤3.0% | 2.723% |
| Zonse Zonyansa | ≤17.0% | 16.223% |
| Assay HPLC (ODB) | Kuchuluka kwa Polymyxins B1, B2,B3 ndi B1-1: ≥80.0% | 86.6% |
| Polymyxin B3: ≤ 6.0% | 3.8% | |
| Polymyxin B1-1: ≤15.0% | 8.5% | |
| Assay, Microbiological (monga momwe zilili) | ≥6500lU/mg | 8255IU/mg |
| Tinthu Kukula | ≥99.0% ≤30um ndi vol | Zimagwirizana |
| ≥90.0% ≤25um ndi vol | ||
| ≥75.0%≤20um ndi vol | ||
| ≥35.0%≤10um ndi vol | ||
| Mapeto | Zogulitsa zimagwirizana ndi USP42 |
|
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofunika kasitomala.
Mkhalidwe Wosungira:Kuwala kosavuta.Sungani chidebecho chotsekedwa mwamphamvu ndikusunga pamalo ozizira, owuma (2~8 ℃) komanso molowera mpweya wabwino kutali ndi zinthu zomwe sizingagwirizane.Tetezani ku kuwala ndi chinyezi.Zosagwirizana ndi ma oxidizing amphamvu.
Manyamulidwe:Kutumiza kudziko lonse lapansi ndi ndege, ndi FedEx / DHL Express.Perekani mwamsanga ndi yodalirika yobereka.
Kodi kugula?Chonde lemberaniDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Zitsanzo?Zogulitsa zambiri zimapereka zitsanzo zaulere zowunikira zabwino, mtengo wotumizira uyenera kulipidwa ndi makasitomala.
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Custom Synthesis?Itha kukupatsirani ntchito zophatikizira zomwe zikugwirizana bwino ndi zosowa zanu zofufuza.
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Zizindikiro Zowopsa Xn - Zowopsa
Zizindikiro Zowopsa 22 - Zowopsa ngati zitamezedwa
Kufotokozera Zachitetezo S22 - Osapumira fumbi.
S24/25 - Pewani kukhudzana ndi khungu ndi maso.
Ma ID a UN 3249
WGK Germany 3
Mtengo wa RTECS TR1150000
FLUKA BRAND F MAKODI 3-8-10
HS kodi 2941909099
Kalasi Yowopsa 6.1(b)
Packing Gulu III
Polymyxin ndi gulu la maantibayotiki a polypeptide opangidwa ndi Bacillus polymyxa (bacilluspolymyxa).Polymyxin B ndi E amagwiritsidwa ntchito ngati mankhwala, ndipo ma sulfates awo amagwiritsidwa ntchito kwambiri.Ma antibacterial sipekitiramu ndi ntchito zachipatala za Polymyxin B Sulfate ndizofanana ndi za polymyxin E. Imakhala ndi zoletsa kapena zowononga bacilli pa gramu-negative bacilli, monga Escherichia coli, Pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, pertussis ndi Shigella.
Polymyxin Sulfate B ndi yofanana ndi polymyxin e, ndipo imakhala ndi zoletsa kapena zowononga tizilombo toyambitsa matenda a gram-negative bacilli, monga e.coli, pseudomonas aeruginosa, paracilli, Klebsiella pneumoniae, acidophilus, bacilli pertussis ndi kamwazi bacilli.Amagwiritsidwa ntchito kwambiri pabala, thirakiti la mkodzo, diso, khutu, trachea ndi mbali zina za matenda omwe amayamba chifukwa cha Pseudomonas aeruginosa ndi Pseudomonas.Itha kugwiritsidwanso ntchito pa sepsis ndi peritonitis.Ndi matenda owopsa omwe amayamba chifukwa cha aminoglycosides, mabakiteriya osamva a cephalosporin a m'badwo wachitatu, Pseudomonas aeruginosa kapena mabakiteriya ena owopsa, monga bacteremia, endocarditis, chibayo, matenda pambuyo powotcha, etc.
1. Kudontha kwa mtsempha: akuluakulu ndi ana omwe ali ndi vuto laimpso 1.5 ~ 2.5mg pa kilogalamu ya kulemera kwa thupi (nthawi zambiri osapitirira 2.5mg pa kilogalamu ya kulemera kwa thupi) kwa tsiku limodzi, logawidwa mu 2 nthawi, kudontha kamodzi pa maola 12 aliwonse.50mg iliyonse ya mankhwalawa imachepetsedwa ndi 500ml ya 5% ya glucose solution kenako ndikudontha.Makanda omwe ali ndi vuto laimpso amatha kulekerera 4mg pa kilogalamu ya kulemera kwa thupi kwa tsiku limodzi.2. Jekeseni wa intramuscular: akuluakulu ndi ana: 2.5 ~ 3mg pa kilogalamu ya kulemera kwa thupi pa 1st, kuperekedwa mumagulu, kamodzi pa maola 4 ~ 6.Makanda amatha kufika 4mg pa kilogalamu ya kulemera kwa thupi patsiku ndipo ana obadwa kumene amatha kufika 4.5mg pa kilogalamu ya kulemera kwa thupi.3. jakisoni wa intrathecal (wa Pseudomonas aeruginosa meningitis): 5mg pa mililita ya mankhwala amadzimadzi okonzedwa ndi jekeseni wa sodium chloride.Akuluakulu ndi ana oposa zaka 2, 5mg tsiku, pambuyo 3-4 masiku ntchito, kusintha kamodzi tsiku lililonse, osachepera 2 milungu, mpaka cerebrospinal madzimadzi chikhalidwe ndi zoipa, ndi shuga zili bwinobwino.Kwa ana osakwana zaka 2, gwiritsani ntchito 2mg kamodzi pa tsiku kwa 3-4 masiku otsatizana (kapena 2.5mg kamodzi tsiku lina lililonse), ndiyeno gwiritsani ntchito 2.5mg kamodzi tsiku lililonse mpaka mayesero ali abwino.4. Kuchuluka kwa madontho a maso ndi 1 ~ 2.5mg pa ml.
Pewani kuphatikizika ndi mankhwala omwe amawononga impso, opumula minofu ya chigoba, maantibayotiki a aminoglycoside, mankhwala opha ululu omwe ali ndi zotsatira zowoneka bwino za kupumula kwa minofu (monga enflurane), etc., ndi quinine, magnesium, etc.Polymyxin B sulphate imaphatikizidwa ndi sulfonamides, rifampicin, semisynthetic penicillin, ndi zina zotero, zochizira matenda aakulu a bakiteriya osamva mankhwala a gram-negative, ndipo zotsatira zake zimakhala zabwino kuposa zogwiritsira ntchito kamodzi.
1, Azimayi apakati ndi oyamwitsa, ana, ndi odwala omwe ali ndi vuto lalikulu la aimpso amakhala ambiri.2. Mankhwalawa ndi owopsa kwambiri ndipo alibe machiritso abwino pa matenda a minofu yakuya.Sichisankho choyamba cha matenda aliwonse.3. Kubaya m'mitsempha kungayambitse kuvutika kupuma, komwe nthawi zambiri sagwiritsidwa ntchito.Osachepera theka la mlingo watsiku ndi tsiku amafunikira kudontha kwa mtsempha, osati kuthamanga mwachangu nthawi imodzi, kuti mupewe chipika chachikulu cha neuromuscular.4. Siziyenera kuphatikizidwa ndi mankhwala ena omwe ali ndi nephrotoxicity kapena neuromuscular blockade kuti apewe ngozi.
Kafukufuku wa biochemical.Polymyxin B ndi anti-gram-negative bacilli polypeptide antibiotic, yomwe imatha kusintha mawonekedwe a nembanemba kuti atayike tinthu tating'onoting'ono ndikulepheretsa kukula kwa mabakiteriya opanda gram.Ili ndi bactericidal effect pa Escherichia coli.Lipid A zigawo zomangika ku bakiteriya lipopolysaccharides.Tizibowo tating'onoting'ono timapangidwa mu membrane yakunja ya khungu.Njira yochitira: imamanga ndikusokoneza kufalikira kwa nembanemba ya cytoplasmic.Antibacterial spectrum: mabakiteriya a gram-negative.
Polymyxin B, Sulfate.
Polymyxin B Sulfate [1405-20-5].
» Polymyxin B Sulfate ndi mchere wa sulphate wa mtundu wa polymyxin, chinthu chomwe chimapangidwa ndi kakulidwe ka Bacillus polymyxa (Prazmowski) Migula (Fam. Bacillaceae), kapena kusakaniza kwa mchere awiri kapena kuposerapo.Ili ndi mphamvu yosachepera 6000 Polymyxin B Units pa mg, yowerengedwa pa zouma.
Kupaka ndi kusunga-Sungani zotengera zolimba, zosagwira kuwala.
Kulemba-Kumene kumapakidwa kuti kuphatikizidwe ndi mankhwala, chizindikirocho chimanena chiwerengero cha Mayunitsi a Polymyxin B mu chidebe ndi milligram imodzi, kuti sichinapangidwe kuti chigwiritsidwe ntchito popanga, kuti sichibala, komanso kuti mphamvu zake sizingatsimikizidwe kwa nthawi yaitali kuposa 60. masiku atatsegula.Kumene akuyenera kugwiritsidwa ntchito popanga jekeseni kapena mafomu ena a mulingo wosabala, chizindikirocho chimati ndi wosabala kapena akuyenera kukonzedwanso panthawi yokonza jekeseni kapena mitundu ina ya jekeseni.
Miyezo yolozera ya USP <11>-
USP Polymyxin B Sulfate RS
Chizindikiritso-
A: Mayeso a Liquid Chromatographic Identification-
Mobile phase-Konzani osakaniza a 0.1 M tribasic sodium phosphate ndi acetonitrile (77:23), ndi kusintha ndi asidi phosphoric kuti pH ya 3.0.Sinthani ngati kuli kofunikira (onani Kuyenerera Kwadongosolo pansi pa Chromatography <621>.
Yankho lokhazikika-Konzani yankho la USP Polymyxin B Sulfate RS mu gawo la Mobile kukhala ndi kuchuluka kwa pafupifupi 3.5 mg pa mL.Tetezani njira iyi ku kuwala.
Njira yothetsera mayeso-Konzani yankho la Polymyxin B Sulfate mu gawo la Mobile lomwe lili ndi kuchuluka kwa pafupifupi 3.5 mg pa mL.Tetezani njira iyi ku kuwala.
Chromatographic system (onani Chromatography <621>) - Chromatograph yamadzimadzi imakhala ndi chowunikira cha 212-nm ndi ndime ya 4.6-mm × 25-cm yomwe ili ndi 5-µm yonyamula L1.Kuthamanga kwa madzi ndi pafupifupi 1 ml pa mphindi.
Kachitidwe-Mosiyanirana jekeseni ma voliyumu ofanana (pafupifupi 10 µL) a njira Yoyezera ndi Mayeso mu chromatograph, ndikujambulitsa ma chromatogram.Chromatogram yopezedwa kuchokera ku Test solution imagwirizana bwino ndi yomwe idapezedwa kuchokera ku Standard solution, ikuwonetsa chiwongola dzanja chachikulu chogwirizana ndi polymyxin B1 ndikufika pachimake pa nthawi yosunga pafupifupi 0.5 (polymyxin B2) ndi 0.6 (polymyxin B3).
B: Sungunulani 2 mg mu 5 mL wa madzi, onjezerani 5 mL wa 2.5 N sodium hydroxide, sakanizani, ndi kuwonjezera madontho 5 a cupric sulfate solution (1 mu 100), kugwedeza pambuyo pa kuwonjezera dontho lililonse: mtundu wofiira wa violet umapangidwa. .
C: Yankho (1 mu 20) limakwaniritsa zofunikira za mayeso a Sulfate <191>.
pH <791>: pakati pa 5.0 ndi 7.5, mu yankho lomwe lili ndi 5 mg pa mL.
Kutaya pakuyanika <731> -Kuwumitsa pafupifupi 100 mg, kuyeza bwino, mu botolo loyimitsidwa ndi capillary mu vacuum pa 60 ℃ kwa maola atatu: imataya osapitirira 7.0% ya kulemera kwake.
Zomwe zili mu phenylalanine-Chotsani pafupifupi 0.375 g ya Polymyxin B Sulfate, yoyezedwa molondola, ku botolo la volumetric 100-mL, sungunulani ndi kusungunula ndi 0.1 N hydrochloric acid ku voliyumu, ndi kusakaniza.Kuyeza absorbances yankho pa maxima pafupifupi 264 nm (A264), 258 nm (A258), ndi 252 nm (A252), ndi absorbances pa 280 nm (A280) ndi 300 nm (A300).Kuwerengera kuchuluka kwa phenylalanine mu gawo la Polymyxin B Sulfate yotengedwa ndi formula:
(9.4787/W) (A258 – 0.5A252 + 0.5A264 – 1.84A280 + 0.8A300)
momwe W ndi kulemera, mu g, wa Polymyxin B Sulfate yotengedwa: ili pakati pa 9% ndi 12% ya phenylalanine, yowerengedwa pa maziko owuma.
Zofunikira zina- Ngati kuphatikizika kwamankhwala, kumakwaniritsa zofunikira za Zotsalira pakuyatsidwa pansi pa Polymyxin B ya jakisoni.Kumene chizindikirocho chimanena kuti Polymyxin B Sulfate ndi wosabala, imakwaniritsa zofunikira pakuyesa kwa Kusabereka <71> ndipo, komwe imapangidwira mawonekedwe a jakisoni, ya Pyrogen pansi pa Polymyxin B ya jekeseni.Kumene chizindikirocho chimanena kuti Polymyxin B Sulfate iyenera kukonzedwanso panthawi yokonzekera mafomu a jekeseni, imakwaniritsa zofunikira za Pyrogen pansi pa Polymyxin B ya Jekiseni.
Kuyesa-Pitirizani ndi Polymyxin B Sulfate monga momwe mukuyendera pansi pa Antibiotics-Microbial Assays <81>.
