Pregabalin CAS 148553-50-8 Purity>99.0% (HPLC) Antiepileptic API
Wopanga ndi High Purity and Commercial Production
Dzina la mankhwala: PregabalinCAS: 148553-50-8
Pregabalin ndi mankhwala a antiepileptic a m'badwo wachiwiri (AED)
Dzina la Chemical | Pregabalin |
Mawu ofanana ndi mawu | (S) -3- (Aminomethyl) -5-Methylhexanoic Acid;PD-144723;PD144723;CI 1008;CI-1008;Lyrica |
Nambala ya CAS | 148553-50-8 |
Nambala ya CAT | RF-API57 |
Stock Status | Mu Stock, Kupanga Kukula Mpaka Matani |
Molecular Formula | C8H17NO2 |
Kulemera kwa Maselo | 159.23 |
Melting Point | 194.0 ~ 196.0 ℃ |
Kusungunuka mu Madzi | Zosasungunuka m'madzi |
Kusungunuka | Kwambiri Pang'ono Kusungunuka mu Ethanol |
Mkhalidwe Wotumiza | Pansi pa Kutentha kwa Ambient |
Mtundu | Ruifu Chemical |
Kanthu | Zofotokozera |
Maonekedwe | Ufa Wa Crystalline Woyera mpaka Woyera |
Chizindikiritso | IR: Zofanana ndi Reference Substance |
Kuzungulira Kwapadera | +10.0°~+13.0° (C=1, Madzi) |
Kutaya pa Kuyanika | <0.50% |
Phulusa la Sulfate | <0.10% |
Zogwirizana nazo | Chidetso A <0.15% |
Zoyipa Zosadziwika Zomwe Zimatuluka Pamaso pa Pregabalin (mayeso A) <0.10% | |
Zosadziwika Zowonongeka Pambuyo pa Pregabalin (kuyesa B) <0.10% | |
Chiwerengero cha mayeso A ndi B <0.50% | |
Purity Wolemba HPLC R-Isomer | <0.15% |
Zitsulo Zolemera (monga Pb) | <10ppm |
Ma chloride (Cl) | <0.05% |
Zosungunulira Zotsalira | |
Mowa wa Isopropyl | <5000ppm |
Ethyl Acetate | <5000ppm |
Tetrahydrofuran | <250ppm |
Isopropyl Ether | <500ppm |
Ethanol | <1000ppm |
Kuyera / Kusanthula Njira | > 99.0% (HPLC pa zouma) |
Test Standard | Enterprise Standard |
Kugwiritsa ntchito | Antiepileptic Drug API |
Phukusi: Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi lamulo la kasitomala
Mkhalidwe Wosungira:Sungani muzitsulo zosindikizidwa pamalo ozizira ndi owuma;Tetezani ku kuwala ndi chinyezi
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Pregabalin ndi mankhwala a antiepileptic a m'badwo wachiwiri (AED) omwe amadziwika ndi dzina la Lyrica (Pfizer, Tadworth) ku UK ndi USA, okhala ndi γ-amino butyric acid kapangidwe kake ka maselo, omwe amakhala ndi anticonvulsant, bwino zopangidwa ndi kampani Pfizer zochizira zotumphukira neuropathic ululu, kapena adjuvant chithandizo cha khunyu pang`ono.Pregabalin ndi mankhwala a Anticonvulsant ndi antiepileptic omwe amagwiritsidwa ntchito pochiza khunyu, ululu wa neuropathic, fibromyalgia, ndi matenda osokonezeka maganizo.Kugwiritsiridwa ntchito kwake kwa khunyu kumakhala ngati chithandizo chowonjezera cha khunyu pang'ono kapena popanda kuwonjezereka kwachiwiri kwa akuluakulu.Mu Disembala 2008, US Food and Drug Administration (FDA) idavomereza pregabalin (dzina lamalonda "Lyrica") kuti azichiza matenda a diabetic peripheral neuropathic pain (DPN) ndi postherpetic neuralgia (PHN) omwe ndi onse omwe amawawa kwambiri a neuropathic.Pregabalin ili ndi chisonyezo chovomerezeka ndipo imagwiritsidwa ntchito kwambiri pochiza matenda anthawi zonse.Mayesero angapo osasinthika, akhungu awiri, oyendetsedwa ndi placebo adapeza kuti pregabalin ndi chithandizo chothandiza kwa odwala omwe ali ndi vuto lanthawi zonse komanso nkhawa zamagulu.Mlingo wa titration Khunyu-adjunctive therapy: 25 mg bd kwa masiku 7, kuwonjezeka ndi 50 mg masiku 7 aliwonse;yokonza mwachizolowezi 300 mg tsiku, ogaŵikana 2 kapena 3 Mlingo (max. 600 mg tsiku, ogaŵikana 2 kapena 3 Mlingo).Generalized nkhawa matenda: 150 mg tsiku, ogaŵikana 2 kapena 3 Mlingo, kwa masiku 7, kuti ziwonjezeke ndi 150 mg aliyense 7 masiku (max. 600 mg tsiku, ogaŵikana 2 kapena 3 Mlingo).Ngati muyimitsa pregabalin, tikulimbikitsidwa kuti tidutse kwa sabata imodzi kuti mupewe kusiya mwadzidzidzi.Chenjezo Odwala omwe ali ndi mikhalidwe yomwe ingayambitse encephalopathy.Odwala kwambiri congestive mtima kulephera.
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