PyBrOP CAS 132705-51-2 Purity> 99.0% (HPLC) Factory Coupling Reagents

Bromotripyrrolidinophosphonium Hexafluorophosphate (PyBrOP) (CAS: 132705-51-2) ndi reagent yokhazikika yogwirizanitsa N-Methylamino acid mu peptide synthesis.Amagwiritsidwa ntchito popanga ma depsipeptides.
PyBroP ndi peptide coupling reagent yomwe yakhala ikugwiritsidwa ntchito popanga chotupa cha rostate chopangidwa ndi peptide-peptoid hybrid prodrugs.Cholumikizira cholumikizira peptide choyenera α, α-dialkyl amino acid.
Chothandizira: kaphatikizidwe ka ma amides oyambira, kuphatikizika kwapadera kwa phosphonium mtanda, kutulutsa mwachindunji, mapangidwe a pyrrolidide ndi phosphonium mchere wolumikizana ndi reagents.
PyBroP ndi mchere wa phosphonium womwe umagwiritsidwa ntchito mu peptide coupling chemistry, wofanana ndi PyCloP.PyBroP ikuwonetsa kuchita bwino kwambiri pakuphatikiza kwa N-methylated amino acid ndi α, α-disubstituted amino acid, zokolola zabwino kwambiri, zopanda epimerization komanso kufulumira kuchitapo kanthu.PyBroP ndi cholimba chokhazikika chomwe chitha kugwiritsidwa ntchito mumphika umodzi ndipo chimasungunuka mu zosungunulira zomwe zimagwiritsidwa ntchito pophatikiza chemistry ya peptide.PyBroP ndi yochokera ku phosphonium coupling reagent BOP koma ili ndi pyrrolidine moiety m'malo mwa dimethylamine ya BOP.Cholinga cha mapangidwe a PyBroP chinali kuteteza kupangidwa kwa HMPA yoopsa kwambiri komanso ya carcinogenic yopangidwa ndi BOP, koma ndi machitidwe ofanana.
PyBroP itha kugwiritsidwa ntchito ngati coupling reagent: Kwa Suzuki-Miyaura cross-coupling wa phenols ndi arylboronic acid kuti apange biaryls ndi heterobiaryls.Kuti agwiritse ntchito ma pyrimidines (opangidwa kuchokera ku 3,4-dihydropyrimidin-2 (1H) -ones (DHPMs) kudzera mu Kappe dehydrogenation) pogwiritsa ntchito ma nucleophiles osiyanasiyana.Kupanga ma formamidine polumikizana ndi ma amine osiyanasiyana oyambira ndi N, N-disopropylethylamine.Itha kugwiritsidwanso ntchito ngati activating reagent: Pakuti kutsegula kwa C-OH chomangira mu tautomerizable heterocycles kupanga phosphonium mchere amene amathandiza Sonogashira lumikiza heterocycles ndi alkynes zosiyanasiyana.Poyambitsa mphika umodzi wa CO bond mu phenols ndikuphatikizananso ndi phosphine oxide kapena phosphite kupanga ma CP bond.