Pyrazinamide CAS 98-96-4 Chiyero>99.0% (HPLC)

Pyrazinamide (CAS: 98-96-4) ndi mzere wachiwiri wotsutsana ndi chifuwa chachikulu.Imakhala ndi antibacterial effect motsutsana ndi mtundu wa anthu wa Mycobacterium tuberculosis yokhala ndi mphamvu yolimbana ndi bakiteriya pamtundu wa pH wa 5-5.5.Ili ndi mphamvu yabwino kwambiri yolimbana ndi Mycobacterium TB mkati mwa maselo a phagocytic omwe amakula pang'onopang'ono m'malo a acidic.pyrazinamide ikalowa m'maselo a phagocytic ndikulowa m'thupi la Mycobacterium tuberculosis, lactamase mu vivo imapangitsa kuti ikhale yodetsedwa, ndikusinthidwa kukhala pyrazine acid kuti ikhale ndi antibacterial effect.Pyrazinamide idapangidwa mu 1952, ndipo ndi nitrogen-analogue ya nicotinamide.Pyrazinamide imagwiritsidwa ntchito pochiza ngati antitubercular agent.Pyrazinamide imagwiritsidwa ntchito popanga ma polymeric copper complexes, kupanga pyrazine carboxamide scaffolds zothandiza ngati FXs inhibitors, komanso ngati gawo la zida zozindikiritsa mycobacteria.Amagwiritsidwa ntchito pophunzira kupewa kawopsedwe ka chiwindi ndi njira zopewera.Pyrazinamide ndi gawo lofunikira kwambiri pamankhwala anthawi yayitali a chifuwa chachikulu.Mophatikiza ndi isoniazid ndi rifampin, imagwira ntchito motsutsana ndi tizilombo toyambitsa matenda omwe angayambitse kuyambiranso.